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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1013 Results for "
Content uniformity test
" in MedChemExpress (MCE) Product Catalog:
Products (1013)
1013 Results for "Content uniformity test" in MCE Product Catalog:
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Crenigacestat (LY3039478) is an orally active Notch and γ-secretase inhibitor, with an IC50 of 1 nM in most of the tumor cell lines tested .
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8 Cited Publications
Cat. No.: HY-P99974
Synonyms: Nanoparticle albumin-bound Paclitaxel; Nanoparticle albumin-bound ABI-007
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7 Cited Publications
Cat. No.: HY-N6771
CAS No.: 18172-33-3
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6 Cited Publications
Synonyms: Tyrphostin 9; Malonoben
Tyrphostin A9, a PDGFR inhibitor, is a potent inducer of mitochondrial fission. Tyrphostin A9 emerged as the most potent and selective of 51 tyrosine kinase inhibitors tested against the TNF-induced respiratory burst. Tyrphostin A9 has anti-influenza virus activities.
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L-685458 is a potent transition state analog (TSA) γ-secretase inhibitor (GSI). L-685458 inhibits amyloid β-protein precursor γ-secretase activity with IC50 of 17 nM, shows greater than 50-100-fold selectivity over other aspartyl proteases tested. L685458 inhibits γ-secretase-mediated cleavage of APP-C99 and Notch-100 with IC50s of 301.3 nM and 351.3 nM, respectively. L-685458 can be used for the research of alzheimer’s disease (AD) and cancers .
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5 Cited Publications
Cat. No.: HY-N4072
CAS No.: 134859-96-4
Category:
Flavonoids Monophenols Glycine max (L.) merr Metabolic Disease Phenols Leguminosae Extract Plants Disease Research Fields Isoflavones
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5 Cited Publications
Cat. No.: HY-W115718
CAS No.: 370-81-0
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Cuprizone is a copper chelating agent that forms a deep blue copper ketone complex with copper (II). The copper ketone reaction can be used in colorimetric tests for the presence of trace copper. Cuprizone can be used to induce some schizophrenia-like behavior in mice. Cuprizone acts on copper enzymes, including SOD1, cytochrome oxidase, and DβH, thereby causing oxidative stress and increasing DA levels in certain brain regions such as the medial prefrontal cortex (PFC) .
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5 Cited Publications
Category:
Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields
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5 Cited Publications
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5 Cited Publications
Cat. No.: HY-D1191
CAS No.: 2225748-05-8
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4 Cited Publications
Synonyms: Symmetric dimethylarginine; NG,NG'-Dimethyl-L-arginine
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Human Gut Microbiota Metabolites Other disease Ketones, Aldehydes, Acids Disease markers Endogenous metabolite Disease Research Fields Inflammation/Immunology
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4
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Mavoglurant (AFQ056) is a potent, selective, non-competitive and orally active mGluR5 antagonist, with an IC50 of 30 nM. Mavoglurant shows a >300 fold selectivity for the mGluR5 over all targets (238) tested. Mavoglurant can be used for the research of Fragile X syndrome (FXS), and L-dopa induced dyskinesias in Parkinson's disease . Mavoglurant is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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4 Cited Publications
Synonyms: Kaempferol 3-O-neohesperidoside
Category:
Flavonols Flavonoids Typha orientalis Presl Typhaceae Extract Metabolic Disease Phenols Polyphenols Plants Disease Research Fields
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3 Cited Publications
Cat. No.: HY-W011094
CAS No.: 1477-57-2
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Win 18446 is an orally active testes-specific enzyme ALDH1a2 inhibitor, with an IC50 of 0.3 μM. Win 18446 reversibly inhibits spermatogenesis in many species and inhibits Retinoic acid (HY-14649) biosynthesis from Retinol (HY-B1342) within the testes .
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Opicapone (BIA 9-1067) is a potent third-generation catechol-O-methyltransferase (COMT) inhibitor for the research of Parkinson's disease and motor fluctuations. Opicapone decreases the ATP content of the cells with an IC50 of 98 μM .
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3 Cited Publications
Synonyms: PVA (Mw 31000-50000, 98-99% hydrolyzed); Poly(Ethenol) (Mw 31000-50000, 98-99% hydrolyzed)
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3 Cited Publications
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DODAP is a cationic lipid utilized as the lipid component in liposomes (pKa = 5.59 in TNS binding tests). DODAP is employed for encapsulating siRNA and delivering immunostimulated chemotherapeutic agents both in vitro and in vivo. DODAP holds great promise for research in vaccines and inflammation .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
