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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
767 Results for "
PPAR
" in MedChemExpress (MCE) Product Catalog:
Products (767)
767 Results for "PPAR" in MCE Product Catalog:
3
3 Cited Publications
Target:
Research Areas:
BMS-687453 is a potent and selective PPARα agonist, with an EC50 and IC50 of 10 nM and 260 nM for human PPARα and 4100 nM and >15000 nM for PPARγ in PPAR-GAL4 transactivation assays.
3
Research Areas:
Fenofibric acid, an active metabolite of fenofibrate, is a PPAR activitor, with EC50s of 22.4 μM, 1.47 μM, and 1.06 μM for PPARα, PPARγ and PPARδ, respectively; Fenofibric acid also inhibits COX-2 enzyme activity, with an IC50 of 48 nM.
3
Category:
Mangifera indica Linn. Plants Endogenous metabolite Infection Human Gut Microbiota Metabolites Anacardiaceae Extract Phenols Polyphenols Disease Research Fields Inflammation/Immunology
Target:
3
3 Cited Publications
Synonyms: N-Oleoylethanolamide; Oleamide MEA; Oleic acid monoethanolamide
Category:
Cardiovascular Disease Human Gut Microbiota Metabolites Natural Products Microorganisms Endogenous metabolite Disease Research Fields
Target:
3
Research Areas:
Choline Fenofibrate (ABT-335), a choline salt of Fenofibric acid (HY-B0760), releases free Fenofibric acid in the gastrointestinal tract. Fenofibric acid is a PPAR activator with antihyperlipidemic effect .
3
3 Cited Publications
Synonyms: 15d-PGJ2; 15-Deoxy-Δ12,14-PGJ2
Category:
Neurological Disease Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Inflammation/Immunology
Target:
3
3 Cited Publications
Cat. No.: HY-N4103
CAS No.: 17605-67-3
Category:
Target:
3
3 Cited Publications
Cat. No.: HY-N0364
CAS No.: 55297-87-5
3
3 Cited Publications
Synonyms: 1,2-Dilauroyl-sn-glycero-3-phosphocholine
Target:
Research Areas:
1,2-DLPC (1,2-Dilauroyl-sn-glycero-3-phosphocholine) is a ligand for LRH-1 agonists. 1,2-DLPC is a phospholipid used in the synthesis of liposomes. 1,2-DLPC enhances fat breakdown and apoptosis in fat cells through a TNFα-dependent pathway, while also inhibiting palmitate-induced insulin resistance through PPARα-mediated inflammation in muscle cells .
3
Target:
Research Areas:
Cardiovascular Disease Inflammation/Immunology Endocrinology
BMS-195614 (BMS 614) is an orally active neutral RARα-selective antagonist with a Ki of 2.5 nM. BMS-195614 restores the expression of Bcl2. BMS-195614 inhibits the transactivation of NF-κB, AP-1 and PPAR. BMS-195614 downregulates the expression of IL-6 and VEGF. BMS-195614 reduces blue light-induced phototoxicity and inhibits cell migration. BMS-195614 modulates inflammation and angiogenesis .
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3
3 Cited Publications
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Research Areas:
TUG-770 is a potent, selective and orally active GPR40/FFA1 agonist with an EC50 of 6 nM for human FFA1. TUG-770 shows a high selectivity for FFA1 over FFA2, FFA3, FFA4, PPARγ, other receptors, transporters, and enzymes. TUG-770 can be uesd for type 2 diabetes research . TUG-770 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
2
2 Cited Publications
Cat. No.: HY-P7996
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PPARA; HPPAR; Prev. PPAR; PPAR-Alpha; Peroxisome Proliferator-Activated Receptor Alpha; Alternative Protein PPARA; NR1C1; PPARalpha; Nuclear Receptor Subfamily 1 Group C Member 1; Peroxisome Proliferator Activated Receptor Alpha; Peroxisome Proliferative Activated Receptor, Alpha
Species:
Human
Source:
E. coli
2
2 Cited Publications
Cat. No.: HY-20019
CAS No.: 79558-09-1
Target:
Research Areas:
L-165041 is a cell permeable PPARδ agonist, with Kis of 6 nM and appr 730 nM for PPARδ and PPARγ, respectively, and induces adipocyte differentiation in NIH-PPARδ cells.
2
2 Cited Publications
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Research Areas:
GW 590735 is a potent and selective PPARα agonist. GW 590735 showsEC50=4 nM on PPARα and at least 500-fold selectivity versus PPARδ and PPARγ. GW 590735 can be used for the research of dyslipidemia .
2
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Ertiprotafib is an inhibitor of PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist, with an IC50 of 1.6 μM for PTP1B, 400 nM for IKK-β, an EC50 of ~1 μM for PPARα/PPARβ.
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2
2
2
2 Cited Publications
Synonyms: (±)-Arabinose; DL-Arabinose; dl-Arabinose
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
