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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
134 Results for "
20S
" in MedChemExpress (MCE) Product Catalog:
Products (134)
134 Results for "20S" in MCE Product Catalog:
271
271 Publications Verification
Synonyms: PS-341; LDP-341; NSC 681239
Research Areas:
Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Bortezomib can be used for the study of multiple myeloma (MM) . Bortezomib effectively inhibits TREM2 expression in tumor-associated macrophages (TAMs) .
66
66 Cited Publications
Synonyms: Tripterine; Tripterin
23
Target:
Research Areas:
Ixazomib (MLN2238) is a selective, potent, and reversible proteasome inhibitor, which inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with an IC50 of 3.4 nM (Ki of 0.93 nM).
20
18
18 Cited Publications
Synonyms: Salinosporamide A; NPI-0052
Category:
Target:
9
9 Cited Publications
Cat. No.: HY-N0603
CAS No.: 14197-60-5
Synonyms: 20(S)-Propanaxadiol; S-ginsenoside Rg3
8
8 Cited Publications
Cat. No.: HY-16594
CAS No.: 133343-34-7
Category:
Target:
5
5 Cited Publications
Cat. No.: HY-N0605
CAS No.: 78214-33-2
Synonyms: 20(S)-Ginsenoside Rh2; 20(S)-Rh2
Category:
Panax ginseng C. A. Meyer Triterpenes Human Gut Microbiota Metabolites Terpenoids Plants Endogenous metabolite Disease Research Fields Araliaceae Cancer
Target:
5
5 Cited Publications
Synonyms: 20α-Hydroxycholesterol
Target:
3
3 Cited Publications
Cat. No.: HY-N0797
CAS No.: 30636-90-9
Synonyms: 20-Epiprotopanaxadiol; 20(S)-APPD
3
3 Cited Publications
Target:
Research Areas:
LONP1-IN-2 (Compound 9e) is a potent and selective LONP1 inhibitor with an IC50 value of 0.093 μM. LONP1-IN-2 can be used in research of cancer .
3
Target:
Research Areas:
2
2 Cited Publications
Cat. No.: HY-N2166
CAS No.: 17406-45-0
Synonyms: α-Tomatine; Lycopersicin; Tomatin
Category:
Target:
2
2 Cited Publications
Target:
Research Areas:
TCH-165 is a small molecule modulator of proteasome assembly, which increases 20S levels and facilitates 20S-mediated protein degradation .
2
2 Cited Publications
Synonyms: 10,11-(Methylenedioxy)-20(S)-camptothecin
FL118 (10,11-(Methylenedioxy)-20(S)-camptothecin), a Camptothecin (HY-16560) analogue, is a potent and orally active survivin inhibitor. FL118 binds to oncoprotein DDX5 (p68) to dephosphorylates and degrades DDX5. FL118 can be used for the research of cancer .
2
2 Cited Publications
Cat. No.: HY-P1259A
Target:
Research Areas:
1
1
1 Cited Publications
Target:
Research Areas:
MG-115 is a potent and reversible proteasome inhibitor, with Kis of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifically inhibit the chymotrypsin-like activity of the proteasome, induces p53-dependent apoptosis .
1
Target:
Research Areas:
1
Category:
Panax ginseng C. A. Meyer Triterpenes Terpenoids Plants Endogenous metabolite Disease Research Fields Araliaceae Cancer
Target:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
