Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
250 Results for "
HO-1
" in MedChemExpress (MCE) Product Catalog:
Products (250)
250 Results for "HO-1" in MCE Product Catalog:
97
Target:
83
72
72 Cited Publications
Synonyms: Zn(II)-protoporphyrin IX; ZnPP; Zinc Protoporphyrin-9
47
47 Cited Publications
Synonyms: RTA 402; NSC 713200; CDDO Methyl ester
Target:
Research Areas:
Bardoxolone methyl (RTA 402) is an orally active and blood-brain-barrier-penetrant activator of Nrf2 and an inhibitor of SARS-CoV-2 3CL protease. Bardoxolone methyl inhibits SARS-CoV-2 replication in Vero cells with an EC50 value of 0.29 μM. Bardoxolone methyl increases levels of pNrf2 and HO-1, inhibits inflammatory mediators like pNFκB and MCP-1. Bardoxolone methyl activates the Nrf2 pathway to enhance antioxidant and anti-inflammatory responses, inhibits viral replication, and improves mitochondrial function. Bardoxolone methyl can be used in research on chemotherapy-induced neuropathic pain (CINP), COVID-19, and chronic kidney disease (CKD) [1] .
24
24 Cited Publications
Synonyms: Tin-protoporphyrin IX; Sn-Protoporphyrin; SnPPIX
Target:
Research Areas:
Tin protoporphyrin IX dichloride (SnPPIX) is a potent Heme oxygenase-1 (HO-1) inhibitor. Tin protoporphyrin IX dichloride sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice model [1].
17
17 Cited Publications
Research Areas:
YS-49 is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1. YS-49 is also an isoquinoline compound alkaloid, has a strong positive inotropic action through activation of cardiac β-adrenoceptors [1] .
17
17 Cited Publications
Research Areas:
YS-49 (monohydrate) is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1. YS-49 is also an isoquinoline compound alkaloid, has a strong positive inotropic action through activation of cardiac β-adrenoceptors [1] .
12
12 Cited Publications
Target:
Research Areas:
Heme Oxygenase-1-IN-1 (Compound 2) hydrochloride is a heme oxygenase 1 (HO-1) inhibitor with an IC50 of 0.25 μM [1].
12
12 Cited Publications
Target:
Research Areas:
Heme Oxygenase-1-IN-1 (compound 2) is a potent heme oxygenase 1 (HO-1) inhibitor, with an IC50 of 0.25 μM. Heme Oxygenase-1-IN-1 can be used for cancer research [1].
12
12
12 Cited Publications
Cat. No.: HY-N0103A
CAS No.: 145572-44-7
11
11 Cited Publications
Cat. No.: HY-N1913
CAS No.: 76822-21-4
Synonyms: Dan shen suan A; Salvianic acid A
11
11 Cited Publications
Cat. No.: HY-N1913A
CAS No.: 81075-52-7
Synonyms: Dan shen suan A sodium; Salvianic acid A sodium
10
10 Cited Publications
Cat. No.: HY-N0028
CAS No.: 79916-77-1
Category:
Plant Simple Phenylpropanols Phenols Polyphenols Phenylpropanoids Oleaceae Extract Disease Research Fields Inflammation/Immunology Forsythia suspensa (Thunb.) Vahl Extract
Target:
10
Target:
Ferroptosis Reactive Oxygen Species (ROS) NOD-like Receptor (NLR) Glutathione Peroxidase ACSL Family Keap1-Nrf2 Heme Oxygenase (HO)
Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease
UAMC-3203 (FXT-001) is a potent ferroptosis inhibitor with an IC50 of 12 nM. UAMC-3203 inhibits NLRP3 inflammasome activation and reactive oxygen species (ROS) production, maintains intracellular glutathione, and acts as a radical-trapping antioxidant in lipid bilayers. UAMC-3203 promotes NRF2/HO-1 antioxidant signaling while restoring GPX4 and xCT and inhibiting ACSL4. UAMC-3203 can be used in research on diabetic peripheral neuropathy, post-stroke cognitive impairment, atherosclerosis, corneal epithelial injury, spinal cord injury, acute iron poisoning, and aortic dissection [1] .
10
10 Cited Publications
Synonyms: FXT-001 hydrochloride
Target:
Ferroptosis Reactive Oxygen Species (ROS) NOD-like Receptor (NLR) Glutathione Peroxidase ACSL Family Keap1-Nrf2 Heme Oxygenase (HO)
Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease
UAMC-3203 (FXT-001) hydrochloride is a potent ferroptosis inhibitor with an IC50 of 12 nM. UAMC-3203 hydrochloride inhibits NLRP3 inflammasome activation and reactive oxygen species (ROS) production, maintains intracellular glutathione, and acts as a radical-trapping antioxidant in lipid bilayers. UAMC-3203 hydrochloride promotes NRF2/HO-1 antioxidant signaling while restoring GPX4 and xCT and inhibiting ACSL4. UAMC-3203 hydrochloride can be used in research on diabetic peripheral neuropathy, post-stroke cognitive impairment, atherosclerosis, corneal epithelial injury, spinal cord injury, acute iron poisoning, and aortic dissection [1] .
8
8 Cited Publications
8
8
Category:
8
Category:
Rutaceae Extract Alkaloids Plant Evodia rutaecarpa (Juss.) Benth./Tetradium ruticarpum (A. Jussieu) T. G. Hartley Extract Disease Research Fields Cancer Indole Alkaloids
Target:
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
