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Results for "

Lactone

" in MedChemExpress (MCE) Product Catalog:

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-134453A

*D-Saccharic acid 1,4-lactone* hydrate** 1 Publications Verification	β-glucuronidase Apoptosis	Cancer
D-Saccharic acid 1,4-lactone hydrate is an orally active β-glucuronidase inhibitor (IC₅₀=48.4 μM). D-Saccharic acid 1,4-lactone hydrate can be used as a standard agent compared with novel β-glucuronidase inhibitors. D-Saccharic acid 1,4-lactone hydrate possesses anticarcinogenic, detoxifying, and antioxidant properties .

HY-114816

N-Butanoyl-L-homoserine lactone 3 Publications Verification C4-HSL; N-Butyryl-L-homoserine Lactone	ADC Linker Bacterial	Infection Inflammation/Immunology
N-Butanoyl-L-homoserine lactone (C4-HSL) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm . N-Butanoyl-L-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa .

HY-N0548

α-Angelica lactone 2 Publications Verification	Glutathione S-transferase	Cancer
α-Angelica lactone is a naturally occurring anticarcinogen and an vinylogous nucleophile. α-Angelica lactone can give the chiral δ-amino γ,γ-disubstituted butenolide carbonyl derivatives and exhibitselectrophilic trapping at the γ-carbon. α-Angelica lactone exerts strong chemoprotective effects by selective enhancement of glutathione-S-thansferase (GST) and UDP-glucononosyltransferase (UGT) detoxification enzymes .

HY-N0591

Dehydrocostus Lactone 2 Publications Verification (-)-Dehydrocostus Lactone; Epiligulyl oxide	Bacterial Apoptosis p38 MAPK NF-κB MAPKAPK2 (MK2) Akt NO Synthase Interleukin Related Caspase	Infection Inflammation/Immunology Cancer
Dehydrocostus Lactone ((-)-Dehydrocostus lactone) is a natural sesquiterpene that can be isolated from Saussurea lappa. Dehydrocostus Lactone has multiple activities such as anti-inflammatory, antibacterial, anti-tumor, and immunomodulatory effects. Dehydrocostus Lactone has an MIC of 2 µg/mL against Mycobacterium tuberculosis. Dehydrocostus Lactone can also inhibit the killing activity of cytotoxic T lymphocytes and induce apoptosis in tumor cells .

HY-41982

D-Glucuronic acid lactone 1 Publications Verification D-Glucurono-6,3-Lactone; D-Glucurono-γ-Lactone; D-GlucuronoLactone; Dicurone; Glucoxy; GlucuroLactone; Glucurone	Environmental Pollutants Endogenous Metabolite Drug Derivative	Cardiovascular Disease Metabolic Disease
D-Glucuronic acid lactone (D-Glucurono-6,3-lactone; D-Glucurono-γ-lactone; D-Glucuronolactone; Dicurone; Glucoxy; Glucurolactone; Glucurone) is an endogenous metabolite and a glucuronic acid derivative. D-Glucuronic acid lactone serves as a starting reagent for the synthesis of 2,3,4-tris (tert-butyldimethylsilyl) glucuronic acid trichloroethyl ester, which is used to prepare 1-O-acyl glucuronic acids for the anti-inflammatory agent mL-3000 (HY-B1452), synthesize optically active glucuronic acids, and produce long-chain alkyl glucuronides. D-Glucuronic acid lactone shows potential for use in studies of reversible cerebral vasoconstriction syndrome (RCVS) .

HY-W008806

N-(3-Oxohexanoyl)-L-homoserine lactone OHHL; N-(3-Oxohexanoyl)homoserine Lactone	Bacterial	Infection Inflammation/Immunology
N-(3-Oxohexanoyl)-L-homoserine lactone (OHHL; N-(3-Oxohexanoyl)homoserine lactone) is a specific agonist of LuxR-type transcription factor CarR with a K_d of 1.8 μM. N-(3-Oxohexanoyl)-L-homoserine lactone activates CarR by inducing protein multimerization, promoting its binding to target DNA sequences in the carR-carA intergenic region, thereby upregulating the transcription of carbapenem biosynthesis genes. N-(3-Oxohexanoyl)-L-homoserine lactone acts as a quorum sensing signal molecule, enabling bacteria to coordinate the production of carbapenem antibiotics in a cell density-dependent manner. N-(3-Oxohexanoyl)-L-homoserine lactone is used to study bacterial quorum sensing mechanisms, especially the secondary metabolism and virulence factor regulatory pathways of Erwinia carotovora and Yersinia enterocolitica .

HY-I0301

D-(+)-Glucono-1,5-lactone 1 Publications Verification Gluconic acid Lactone	Environmental Pollutants Endogenous Metabolite Reactive Oxygen Species (ROS)	Others
D-(+)-Glucono-1,5-lactone is a polyhydroxy (PHA) that is capable of metal chelating, moisturizing and antioxidant activity.

HY-107411

Bromoenol lactone 3 Publications Verification (6E)-Bromoenol Lactone	Phospholipase	Inflammation/Immunology
Bromoenol lactone ((6E)-Bromoenol lactone) is a suicide-based irreversible, selective, potent inhibitor of calcium-independent phospholipase A₂ (iPLA₂β) with an IC₅₀ value of approximately 7 μM, which inhibits antigen-stimulated mast cell exocytosis without blocking Ca ²⁺ influx .

HY-125643

Pitavastatin lactone	Drug Metabolite	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Pitavastatin lactone is a major metabolite of Pitavastatin (HY-B0144A) in humans. Pitavastatin is a potent competitive inhibitor of HMG-CoA reductase .

HY-101873

Atorvastatin lactone	HMG-CoA Reductase (HMGCR) Drug Metabolite	Neurological Disease
Atorvastatin lactone is a myotoxic reagent and a metabolite of Atorvastatin acid, an HMG-CoA reductase inhibitor. Atorvastatin lactone exhibits myotoxicity .

HY-138166

Rosuvastatin lactone	Drug Metabolite	Metabolic Disease
Rosuvastatin lactone is a metabolite of Rosuvastatin (HY-17504A) (HMG-CoA inhibitor) .

HY-N7347

(-)-Hydroxycitric acid lactone Garcinia Lactone	ATP Citrate Lyase	Metabolic Disease
(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis .

HY-W008393

*(-)-Corey lactone* diol**	Drug Intermediate	Cardiovascular Disease Inflammation/Immunology
(-)-Corey lactone diol is the reduced form of Corey aldehyde. (-)-Corey lactone diol can be used as a drug intermediate for the synthesis of Beraprost (HY-13569A) .

HY-W587796

6-Phosphoglucono-δ-lactone 6-PGδL; 6-Phosphonoglucono-D-Lactone	Endogenous Metabolite	Cardiovascular Disease Metabolic Disease Cancer
6-Phosphoglucono-δ-lactone (6-PGδL), a reversal substrate of glucose-6-phosphate dehydrogenase (G6PD), is an intermediate compound in the oxidative branch of the pentose phosphate pathway (PPP). 6-Phosphoglucono-δ-lactone produced from D-glucose-6-phosphate by glucose-6-phosphate dehydrogenase (G6PDH) and is converted to 6-phosphoglutonate by lactonase. 6-Phosphoglucono-δ-lactone can be used for heart failure, type 2 diabetes and cancers research .

HY-N7435

Massoia lactone 1 Publications Verification (±)-Massoia Lactone	Others	Others
Massoia lactone ((±)-Massoia lactone) is a coconut and creamy fragrant compound mianly isolated from Cryptocarya massoy. Massoia lactone is also a fragrant biosurfactant produced by a fungus Aureobasidium pullulans .

HY-114816R

*N-Butanoyl-L-homoserine lactone* (Standard)** C4-HSL (Standard); N-Butyryl-L-homoserine Lactone (Standard)	Reference Standards ADC Linker Bacterial	Infection Inflammation/Immunology Cancer
N-Butanoyl-L-homoserine lactone (Standard) (C4-HSL (Standard)) is the analytical standard of N-Butanoyl-L-homoserine lactone (HY-114816). This product is intended for research and analytical applications. N-Butanoyl-L-homoserine lactone (C4-HSL) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm. N-Butanoyl-L-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa.

HY-129405

N-(Ketocaproyl)-DL-homoserine lactone	Bacterial	Infection
N-(Ketocaproyl)-DL-homoserine lactone is a natural, very active ligand of LuxR. N-(Ketocaproyl)-DL-homoserine lactone is a quorum sensing (QS) autoinducer .

HY-113764

N-Butanoyl-DL-homoserine lactone (Rac)-C4-HSL	Bacterial	Infection Inflammation/Immunology
N-Butanoyl-DL-homoserine lactone ((Rac)-C4-HSL) is a racemic mixture of N-Butanoyl-D-homoserine lactone and N-Butanoyl-L-homoserine lactone. N-Butanoyl-L-homoserine lactone is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm. N-Butanoyl-L-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa .

HY-133683

N-(3-Oxotetradecanoyl)-DL-homoserine lactone 3-Oxo-C14-AHL	Bacterial	Metabolic Disease
N-(3-Oxotetradecanoyl)-DL-homoserine lactone, a member of N-Acyl homoserine lactone (AHL) from gram-negative bacteria, is a quorum sensing (QS) signaling molecule .

HY-121795

Pravastatin lactone	HMG-CoA Reductase (HMGCR)	Cardiovascular Disease
Pravastatin lactone is a potent HMG-CoA inhibitor. Pravastatin Lactone is a metabolite of pravastatin. Pravastatin lactone reduces blood cholesterol levels by inhibiting cholesterol synthesis .

HY-W017445

Homogentisic acid lactone	Fungal	Infection
Homogentisic acid lactone (Compound 1) is a fungal metabolite with fungicidal activity, which is found in the fungus WF5. Homogentisic acid lactone is active against the plant pathogenic fungus F. graminearum. Homogentisic acid lactone can be used as a substrate in the determination of serum paraoxonase/arylesterase 1 (PON1) activity .

HY-W015800

*L-Homoserine lactone* hydrochloride**	Drug Intermediate	Others
L-Homoserine lactone hydrochloride is the core structural unit of the bacterial quorum-sensing signal molecule N-acyl-L-homoserine lactone (AHLs). As an important intermediate, L-Homoserine lactone hydrochloride acylated derivatives have potent immunosuppressive activity .

HY-W047191

D-Glucono-1,4-lactone	Biochemical Assay Reagents	Others
D-Glucono-1,4-lactone is a biochemical reagent.

HY-W016628

L-Gulono-1,4-lactone L-GulonoLactone	Endogenous Metabolite	Metabolic Disease
L-Gulono-1,4-lactone is a substrate of L-gulono-1,4-lactone oxidoreductase, which catalyzes the last step of the biosynthesis of L-ascorbic (Vatamin) C. In other words, L-Gulono-1,4-lactone is a direct precursor of vitamin C in animals, in plants and in some protists.

HY-133879

Calcitriol lactone 1α,25-Dihydroxyvitamin D3-26,23-Lactone	Endogenous Metabolite	Others Inflammation/Immunology
Calcitriol lactone (1α,25-Dihydroxyvitamin D3-26,23-lactone) is a metabolite of vitamin D3. Calcitriol lactone is the active form of vitamin D and affects bone health, cell differentiation, immune function .

HY-41840

*D-Glucurono-6,3-lactone* acetonide**	Drug Intermediate	Others
D-Glucurono-6,3-lactone acetonide is a acetone-protected derivative of D-Glucurono-6,3-lactone (HY-41982) that can be used as a synthetic intermediate.

HY-W243002

Acetyl-L-homoserine lactone	Bacterial	Infection
Acetyl-L-homoserine lactone is a member of the family of N-acylated homoserine lactones (HSLs). Acetyl-L-homoserine lactone is a polar mediator of cell-cell interactions in bacterial biofilms .

HY-20003

*(-)-Corey lactone* benzoate**	Biochemical Assay Reagents	Others
(-)-Corey lactone benzoate is a building block in the chemical synthesis of corey aldehyde .

HY-W008393R

*(-)-Corey lactone* diol (Standard)**	Drug Intermediate Reference Standards	Cardiovascular Disease Inflammation/Immunology
(-)-Corey lactone diol (Standard) is an analytical standard for (-)-Corey lactone diol (HY-W0088393). This product is intended for research and analytical applications. (-)-Corey lactone diol is the reduced form of Corey aldehyde. (-)-Corey lactone diol can be used as a pharmaceutical intermediate in the synthesis of Beraprost (HY-13569A).

HY-N0548R

*α-Angelica lactone* (Standard)**	Glutathione S-transferase Reference Standards	Cancer
α-Angelica lactone (Standard) is the analytical standard of α-Angelica lactone. This product is intended for research and analytical applications. α-Angelica lactone is a naturally occurring anticarcinogen and an vinylogous nucleophile. α-Angelica lactone can give the chiral δ-amino γ,γ-disubstituted butenolide carbonyl derivatives and exhibitselectrophilic trapping at the γ-carbon. α-Angelica lactone exerts strong chemoprotective effects by selective enhancement of glutathione-S-thansferase (GST) and UDP-glucononosyltransferase (UGT) detoxification enzymes .

HY-W391625

(Rac)-Dehydrocostus Lactone (Rac)-Epiligulyl oxide	Fungal	Cancer
(Rac)-Dehydrocostus Lactone ((Rac)-Epiligulyl oxide) is a natural product with antiparasitic activity. (Rac)-Dehydrocostus Lactone can significantly inhibit the growth of Trypanosoma brucei rhodesiense. (Rac)-Dehydrocostus Lactone exhibits a broad spectrum of biological effects, including anti-inflammatory, anticancer, antiviral and antimicrobial activities. (Rac)-Dehydrocostus Lactone also has antifungal, antioxidant, antidiabetic, antiulcer and antihelminthic effects. (Rac)-Dehydrocostus Lactone exhibits different IC(50) values in cytotoxicity tests and has a high selectivity index .

HY-133684R

*N-Tetradecanoyl-L-homoserine lactone* (Standard)**	Reference Standards Bacterial	Infection
N-Tetradecanoyl-L-homoserine lactone (Standard) is the analytical standard of N-Tetradecanoyl-L-homoserine lactone (HY-133684). This product is intended for research and analytical applications. N-Tetradecanoyl-L-homoserine lactone is a short-chained N-acyl homoserine lactone (AHL). Diatoms are frequently found in association with Proteobacteria, many members of which employ cell-to-cell communication via AHLs in aquatic habitats.

HY-124237

N-Octanoyl-DL-homoserine lactone	Bacterial	Others
N-Octanoyl-DL-homoserine lactone is a member of N-acyl homoserine lactones (AHLs) family, also one of the signal molecule of quorum-sensing (QS) signals. N-Octanoyl-DL-homoserine lactone can regulate the production of siderophores and present positive correlation in Aeromonas sobria strain AS7. N-Octanoyl-DL-homoserine lactone can also regulate the secretion of proteases and stimulate the production of total volatile basic nitrogen (TVB-N) .

HY-116246

5(S)-HETE lactone	Drug Metabolite	Inflammation/Immunology
5(S)-HETE lactone is an arachidonic acid (AA) metabolite .

HY-Z8147

16-O-Deacetyl fusidic acid lactone 16-Deacetylfusidic acid γ-Lactone	Bacterial	Infection
16-O-Deacetyl fusidic acid lactone (16-Deacetylfusidic acid γ-lactone) (FA-9) is a Fusidic acid (HY-B1350) (FA) lactone derivative with antibacterial effects. 16-O-Deacetyl fusidic acid lactone is effective against Gram-positive bacteria, but has no inhibitory effect on Gram-negative bacteria .

HY-123087

N-(3-Hydroxytetradecanoyl)-DL-homoserine lactone N-(3-oxodecanoyl)-homoserine Lactone	Bacterial	Infection
N-(3-Hydroxytetradecanoyl)-DL-homoserine lactone (N-(3-oxodecanoyl)-homoserine lactone) is a member of N-Acyl homoserine lactone (AHL) from V. alginolyticus strains. N-(3-Hydroxytetradecanoyl)-DL-homoserine lactone is used for biofilm formation and has antibacterial activity .

HY-113801

N-(3-Oxooctanoyl)-DL-homoserine lactone (Rac)-3-oxo-C8-HSL	Endogenous Metabolite	Metabolic Disease
N-(3-Oxooctanoyl)-DL-homoserine lacton is a member of N-Acyl homoserine lactone (AHL) from gram-negative bacteria, with stereochemistry-dependent growth regulatory activity for roots .

HY-101873S

*Atorvastatin lactone-d5*	Isotope-Labeled Compounds HMG-CoA Reductase (HMGCR)	Metabolic Disease Inflammation/Immunology
Atorvastatin lactone-d₅ is a deuterated form of Atorvastatin lactone (HY-101873). Atorvastatin lactone is a proagent form of atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor .

HY-43001

(−)-G-Lactone	Drug Intermediate	Others
(−)-G-Lactone is a synthetic intermediate useful for prostaglandins synthesis .

HY-176301

Tetranor-PGDM lactone Tetranor-prostaglandin D metabolite Lactone	Endogenous Metabolite	Inflammation/Immunology Endocrinology
Tetranor-PGDM lactone (Tetranor-prostaglandin D metabolite lactone) is a urinary metabolite of PGD2 (HY-101988). Prostaglandin D2 (PGD2) is one of the most potent endogenous sleep promoting substances. PGD2 plays a protective role by suppressing inflammation .

HY-125678

Jasmine lactone	Others	Others
Jasmine lactone, a volatile substance produced by plants under stress, has a strong odor and is known for its unique jasmine-like floral and fruity scent which is very popular in tea, especially in oolong and black tea. The biosynthesis mechanism of Jasmine lactone in tea is regulated by various stresses, including mechanical damage and low temperature stress. Continuous mechanical damage and low temperature and mechanical damage can enhance the accumulation of Jasmine lactone in tea .

HY-115393A

N-Heptanoyl-L-homoserine lactone	Bacterial	Infection
N-Heptanoyl-L-homoserine lactone is a member of N-acyl-homoserine lactone family. N-acyl-homoserine lactones (AHL) can regulate gene expression in gram-negative bacteria, such as Echerichia and Salmonella, and are involved in quorum sensing, cell to cell communication among bacteria.

HY-135406

(3R,5R)-Rosuvastatin Lactone	Drug Isomer	Cardiovascular Disease Metabolic Disease
(3R,5R)-Rosuvastatin Lactone is an isomer of Rosuvastatin Lactone.

HY-125946

*Latanoprost lactone* diol**	Drug Intermediate	Endocrinology
Latanoprost lactone diol is a small organic molecule derived from Prostaglandin F2α (HY-12956), serving as a key synthetic intermediate and inactive metabolism-related form of Latanoprost (HY-B0577). Latanoprost lactone diol is significantly upregulated in hypothyroid rats, and its level can be reversed by crude polysaccharide, lactone and oligosaccharide fractions from the rhizome of Atractylodis macrocephalae. Latanoprost lactone diol can be used in studies related to hypothyroidism .

HY-P1709

Protactin	Bacterial	Infection
Protactin is a pentapeptide lactone produced by Streptomyces cucumeris strain L703-4 (ATCC 53784) with significant antioxidant properties. Protactin can be converted to actinomycin Zp by ferrocyanide oxidation. Actinomycin Zp exhibits potent antibacterial activity in vitro and has significant antitumor effects against P-388 leukemia in a mouse model .

HY-133683R

*N-(3-Oxotetradecanoyl)-DL-homoserine lactone* (Standard)** 3-Oxo-C14-AHL (Standard)	Bacterial Reference Standards	Metabolic Disease
N-(3-Oxotetradecanoyl)-DL-homoserine lactone (Standard) is the analytical standard of N-(3-Oxotetradecanoyl)-DL-homoserine lactone. This product is intended for research and analytical applications. N-(3-Oxotetradecanoyl)-DL-homoserine lactone, a member of N-Acyl homoserine lactone (AHL) from gram-negative bacteria, is a quorum sensing (QS) signaling molecule[1][2].

HY-N7347R

*(-)-Hydroxycitric acid lactone* (Standard)** Garcinia Lactone (Standard)	Reference Standards ATP Citrate Lyase	Metabolic Disease
(-)-Hydroxycitric acid lactone (Standard) is the analytical standard of (-)-Hydroxycitric acid lactone. This product is intended for research and analytical applications. (-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis .

HY-I0301R

*D-(+)-Glucono-1,5-lactone* (Standard)** Gluconic acid Lactone (Standard)	Reference Standards Endogenous Metabolite Reactive Oxygen Species (ROS)	Others
D-(+)-Glucono-1,5-lactone (Standard) is the analytical standard of D-(+)-Glucono-1,5-lactone. This product is intended for research and analytical applications. D-(+)-Glucono-1,5-lactone is a polyhydroxy (PHA) that is capable of metal chelating, moisturizing and antioxidant activity.

HY-W399193

PGF2α 1,9-lactone Prostaglandin F2α 1,9-Lactone	Prostaglandin Receptor	Metabolic Disease
PGF2α 1,9-lactone (Prostaglandin F2α 1,9-lactone) is a prostaglandin lactone. PGF2α 1,9-lactone shows resistant to hydrolysis by plasma esterases .

HY-N0591R

*Dehydrocostus Lactone* (Standard)** (-)-Dehydrocostus Lactone (Standard); Epiligulyl oxide (Standard)	Reference Standards Bacterial Apoptosis p38 MAPK NF-κB MAPKAPK2 (MK2) Akt NO Synthase Interleukin Related Caspase	Infection Inflammation/Immunology Cancer
Dehydrocostus Lactone (Standard) ((-)-Dehydrocostus lactone (Standard)) is the analytical standard of Dehydrocostus Lactone (HY-N0591). This product is intended for research and analytical applications. Dehydrocostus Lactone is a natural sesquiterpene that can be isolated from Saussurea lappa. Dehydrocostus Lactone has multiple activities such as anti-inflammatory, antibacterial, anti-tumor, and immunomodulatory effects. Dehydrocostus Lactone has an MIC of 2 µg/mL against Mycobacterium tuberculosis. Dehydrocostus Lactone can also inhibit the killing activity of cytotoxic T lymphocytes and induce apoptosis in tumor cells.

Cat. No.	Product Name

HY-L241

Chinese Baijiu Compound Library

671 compounds

Chinese Baijiu is one of the oldest alcoholic beverages in the world, with a history of over 2,000 years. It can be classified into 12 aroma types based on its fragrance and flavor characteristics. The specific flavor profile of Baijiu is determined by the composition and concentration of certain compounds. These trace compounds, present in low concentrations yet rich in esters, alcohols, acids, lactones, aldehydes, ketones, acetals, alkenes, and others, significantly influence the flavor of Baijiu. Additionally, some active components in Baijiu possess antioxidant properties, and moderate consumption may help reduce the risk of cardiovascular diseases, dementia, and insulin resistance. Therefore, studying the chemical composition of Baijiu is crucial for promoting its fermentation process and enhancing its flavor and quality.

MCE has compiled included 671 Chinese Baijiu components, which can be used for drug development, Baijiu fermentation, and research related to Baijiu flavor and aroma.

Cat. No.	Product Name	Type

HY-66020

6-FITC 1 Publications Verification 6-Fluorescein Isothiocyanate	Fluorescent Dye
6-FITC (6-Fluorescein Isothiocyanate) is a fluorescein isomer and also serves as a fluorescent label for biomolecules (FITC isomers have similar excitation/emission wavelengths, which are 495 nm/519 nm in fluorescence detection) .

HY-D0214A

Acid Red 94 lactone

1 Publications Verification

Fluorescent Dye

Acid Red 94 lactone is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells.

HY-D2966

TMR-NO-BG	Fluorescent Dye
TMR-NO-BG is a hybrid probe (Ex/Em: 557 nm/571 nm). TMR-NO-BG covalently connects the tetramethylrhodamine (TMR) lactone NO sensing unit with the SNAP-tag reactive benzyl guanine (BG) for achieving subcellular-specific nitric oxide (NO) detection .

Cat. No.	Product Name	Type

HY-59156

Triazabicyclodecene	Biochemical Assay Reagents
Triazabicyclodecene is a bicyclic guanidine compound that can serve as a pharmaceutical intermediate for the formation of amides or esters .

HY-W005485

Tetra-O-benzyl-δ-D-Gluconolactone 2,3,4,6-Tetra-O-benzyl-D-glucono-1,5-Lactone	Biochemical Assay Reagents
Tetra-O-benzyl-δ-D-Gluconolactone (2,3,4,6-Tetra-O-benzyl-D-glucono-1,5-lactone) is a 1,5-sugar lactone and protected D-glucono-1,5-lactone, which serves as a synthetic intermediate in the field of carbohydrate chemistry. Tetra-O-benzyl-δ-D-Gluconolactone acts as a model substrate for zinc-mediated Barbier allylation, crotylation and propargylation reactions .

HY-W047191

D-Glucono-1,4-lactone	Biochemical Assay Reagents
D-Glucono-1,4-lactone is a biochemical reagent.

HY-W050049

*2-Deoxy-2,2-difluoro-D-erythro-pentonic acid γ-Lactone* 3,5-dibenzoate**	Biochemical Assay Reagents
2-Deoxy-2,2-difluoro-D-erythro-pentonic acid γ-Lactone 3,5-dibenzoate is a chemically synthesized fluorinated carbohydrate derivative that can be used in glycobiology research .

HY-41840

*D-Glucurono-6,3-lactone* acetonide**	Biochemical Assay Reagents
D-Glucurono-6,3-lactone acetonide is a acetone-protected derivative of D-Glucurono-6,3-lactone (HY-41982) that can be used as a synthetic intermediate.

HY-W127393

N-Nonanoyl-L-homoserine lactone

Biochemical Assay Reagents

Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C9-HSL is a rare odd-numbered acyl carbon chain produced by wild-type Erwinia carotovora strain SCC 3193 grown in nutrient-rich Luria-Bertani broth (LB) medium.

HY-W155493

L-Galactono-1,4-lactone	Biochemical Assay Reagents
L-Galactono-1,4-lactone is a kind of biochemical reagent.

HY-134453

L-Idaric acid,1,4-lactone	Biochemical Assay Reagents
L-Idaric acid,1,4-lactone is a biochemical assay reagent.

HY-W105876

D-Mannonic acid-1,4-lactone	Biochemical Assay Reagents
D-Mannonic acid-1,4-lactone is a kind of biochemical reagent.

HY-W130052

D-Lyxono-1,4-lactone	Biochemical Assay Reagents
d-Lyxono-1,4-lactone is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W145487

D-Xylono-1,4-lactone	Biochemical Assay Reagents
D-Xylono-1,4-lactone is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W040253

D-Glycero-D-gulo-heptono-1,4-lactone	Biochemical Assay Reagents
D-Glycero-D-gulo-heptono-1,4-lactone is a kind of biological materials or organic compounds that are widely used in life science research.

HY-W416216

*D-Gulonic acid,γ-lactone,2,3,5,6-tetraacetate*	Biochemical Assay Reagents
D-Gulonic acid,γ-lactone,2,3,5,6-tetraacetate is a biochemical assay reagent.

HY-W705252

D-Talonic acid,γ-lactone

Biochemical Assay Reagents

D-Talonic acid,γ-lactone is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .

HY-116283

2,3:5,6-Di-O-isopropylidene-L-gulono-1,4-lactone

Biochemical Assay Reagents

2,3:5,6-Di-O-isopropylidene-L-gulono-1,4-lactone is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .

HY-W127486

N-3-oxo-Hexadec-11Z-enoyl-L-homoserine lactone	Biochemical Assay Reagents
N-3-oxo-hexadec-11Z-enoyl-L-Homoserine lactone is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W127487

N-Octadecanoyl-L-homoserine lactone

Biochemical Assay Reagents

Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C18-HSL, one of four lipophilic long acyl side chain AHLs produced by the LuxI AHL synthase homolog SinI, is involved in quorum-sensing signaling in strains of Rhizobium meliloti (a nitrogen-fixing bacterial symbiont of the legume M. sativa) . C18-HSL and other hydrophobic AHLs tend to localize in the relatively lipophilic environment of bacterial cells and cannot diffuse freely across the cell membrane. Long-chain N-acyl homoserine lactones can be exported from cells by efflux pumps, or can be transported between communicating cells by extracellular outer membrane vesicles.

HY-W698874

2-Acetamido-4,6-O-benzylidene-2-deoxy-D-gluconohydroximo-1,5-lactone

Biochemical Assay Reagents

2-Acetamido-4,6-O-benzylidene-2-deoxy-D-gluconohydroximo-1,5-lactone is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .

HY-114773

N-Undecanoyl-L-homoserine lactone

Biochemical Assay Reagents

Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C11-HSL has a rare odd-numbered acyl carbon chain and may be a minor quorum-sensing signaling molecule in Pseudomonas aeruginosa strains.

HY-W701862

5-Azido-6-(tert-butyldimethylsilyl)-2,3-O-isopropylidene L-gulono-1,4-lactone

Biochemical Assay Reagents

5-Azido-6-(tert-butyldimethylsilyl)-2,3-O-isopropylidene L-gulono-1,4-lactone is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .

HY-41357

2,3-O-(1-Methylethylidene)-L-lyxonic acid γ-lactone

Biochemical Assay Reagents

2,3-O-(1-Methylethylidene)-L-lyxonic acid γ-lactone is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .

HY-I0596

D-Ribonic acid,2-C-methyl,γ-lactone,2,3,5-tribenzoate

Biochemical Assay Reagents

D-Ribonic acid,2-C-methyl,γ-lactone,2,3,5-tribenzoate is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .

HY-116762

N-butyryl-L-Homocysteine thiolactone

Biochemical Assay Reagents

Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. The control of bacterial infection by quenching the quorum sensing system of bacteria is a promising research area. The expression of specific target genes, such as transcriptional regulators belonging to the LuxIR protein family, is coordinated by the synthesis of diffusible acyl homoserine lactone (AHL) molecules. N-butyryl-L-Homocysteine thio-lactone is an analog of N-butyryl-L-homoserine lactone, a small, diffusible signaling molecule involved in quorum sensing, thereby controlling gene expression and cellular metabolism . N-butyryl-L-homocysteine thiolactone induces violacein expression in Viola viola mutants that normally fail to produce AHL.

HY-N10272

(±)-Avenaciolide	Biochemical Assay Reagents
Avenaciolide is an antifungal bis-γ-lactone found in Aspergillus avenaceus. Avenaciolide has also antibacterial action. Avenaciolide is a specific inhibitor of glutamate transport in rat liver mitochondria. Avenaciolide interferes with the ability of ADP to stimulate the rate of glutamate oxidation .

HY-W778986

L-Allono-1,4-lactone

Biochemical Assay Reagents

L-allono-1, 4-Lactone is a class of biochemical reagents used in the study of glycobiology. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It deals with carbohydrate chemistry, glycan formation and degradation enzymology, protein-glycan recognition, and the role of glycans in biological systems. The field is closely related to basic research, biomedicine and biotechnology .

HY-W408789

*2-Acetamido-2-deoxy-D-glucono-1,5-lactone, 90%*	Biochemical Assay Reagents
2-Acetamido-2-deoxy-D-glucono-1,5-lactone, 90% can be used in sugar science research.

HY-W127610

N-hexadecanoyl-L-Homoserine lactone	Biochemical Assay Reagents
N-hexadecanoyl-L-Homoserine lactone is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-118351

N-Tridecanoyl-L-homserine lactone	Biochemical Assay Reagents
N-tridecanoyl-L-Homserine lactone is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W416204

2,3,4,6-Tetra-O-benzyl-D-galactono-1,5-lactone

Biochemical Assay Reagents

2,3,4,6-Tetra-O-benzyl-D-galactono-1,5-lactone is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .

HY-W795499

D-Erythro-L-talo-octonic acid,γ-lactone

Biochemical Assay Reagents

D-Erythro-L-talo-octonic acid,γ-lactone is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .

HY-W077275

5,6-Isopropylidene-L-gulonic acid γ-lactone

Biochemical Assay Reagents

5,6-Isopropylidene-L-gulonic acid γ-lactone is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .

HY-W698427

D-Mannonic acid,2-(acetylamino)-2-deoxy,γ-lactone

Biochemical Assay Reagents

D-Mannonic acid,2-(acetylamino)-2-deoxy,γ-lactone is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .

HY-W698426

D-Galactonic acid,2-(acetylamino)-2-deoxy,γ-lactone

Biochemical Assay Reagents

D-Galactonic acid,2-(acetylamino)-2-deoxy,γ-lactone is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .

Cat. No.	Product Name	Target	Research Area

HY-P3990

Coibamide A	VEGFR Autophagy Apoptosis	Cancer
Coibamide A, an N-methyl-stabilized cytotoxic depsipeptide, shows potent antiproliferative activity. Coibamide A induces autophagosome accumulation via an mTOR-independent mechanism. Coibamide A induces apoptosis. Coibamide A inhibits VEGFA/VEGFR2 expression and suppresses tumor growth in glioblastoma xenografts .

HY-W015800

*L-Homoserine lactone* hydrochloride**	Drug Intermediate	Others
L-Homoserine lactone hydrochloride is the core structural unit of the bacterial quorum-sensing signal molecule N-acyl-L-homoserine lactone (AHLs). As an important intermediate, L-Homoserine lactone hydrochloride acylated derivatives have potent immunosuppressive activity .

HY-W142093

N-Tetradecanoyl-DL-homoserine lactone	Amino Acid Derivatives	Others
N-Tetradecanoyl-DL-homoserine lactone is a serine derivative .

HY-124237

N-Octanoyl-DL-homoserine lactone	Bacterial	Others
N-Octanoyl-DL-homoserine lactone is a member of N-acyl homoserine lactones (AHLs) family, also one of the signal molecule of quorum-sensing (QS) signals. N-Octanoyl-DL-homoserine lactone can regulate the production of siderophores and present positive correlation in Aeromonas sobria strain AS7. N-Octanoyl-DL-homoserine lactone can also regulate the secretion of proteases and stimulate the production of total volatile basic nitrogen (TVB-N) .

HY-115393

N-Heptanoyl-DL-homoserine lactone	Amino Acid Derivatives	Others
N-Heptanoyl-DL-homoserine lactone is a serine derivative .

HY-P1720

Telomycin	Antibiotic Bacterial	Infection
Telomycin is a calcium-dependent antibiotic, which can be produced by Streptomyces. Telomycin inhibits gram-positive bacteria, including multidrug-resistant (MDR) pathogens .

HY-P1709

Protactin	Bacterial	Infection
Protactin is a pentapeptide lactone produced by Streptomyces cucumeris strain L703-4 (ATCC 53784) with significant antioxidant properties. Protactin can be converted to actinomycin Zp by ferrocyanide oxidation. Actinomycin Zp exhibits potent antibacterial activity in vitro and has significant antitumor effects against P-388 leukemia in a mouse model .

HY-W044573

N-Dodecanoyl-DL-homoserine lactone	Amino Acid Derivatives	Others
N-Dodecanoyl-DL-homoserine lactone is a serine derivative .

HY-W045072

N-Decanoyl-DL-homoserine lactone	Amino Acid Derivatives	Others
N-Decanoyl-DL-homoserine lactone is a serine derivative .

HY-W141788

N-Butyryl-DL-homocysteine thiolactone	Bacterial	Infection
N-Butyryl-DL-homocysteine thiolactone is an N-acyl homoserine lactone (AHL) analogue. AHLs are potent inhibitors of biofilm formation and virulence factors, and has been used for degrading microbial communities, reducing bacterial pathogenicity .

HY-P6372

SDZ 280-446	Peptides
SDZ 280-446 is an orally active semisynthetic cyclic peptide lactone. SDZ 280-446 can be used in anticancer research .

HY-P11022

TL-119 A-3302-B	Endogenous Metabolite HSV TRP Channel	Infection Cancer
TL-119 (A-3302-B) is a polypeptide. TL-119 can be isolated from the bacteria Micromonospora sp. MAG 9-7 and Saccharomonospora sp. CNQ-490. TL-119 inhibits TRPV-1. TL-119 exhibits antiviral activity against HSV-2. TL-119 possesses anticancer activity against gastric cancer and colorectal cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0784

Ginkgolide B 10+ Cited Publications BN-52021	Ginkgoaceae Classification of Application Fields Terpenoids Diterpenoids Plants Endogenous metabolite Ginkgo biloba Disease Research Fields Source Classification Cancer	Platelet-activating Factor Receptor (PAFR) Apoptosis
Ginkgolide B (BN-52021), a terpene lactone, is a potent platelet activating factor antagonist. Ginkgolide B protects endothelial cells via the activation of PXR from injuries induced by xeno- and endobiotics. Ginkgolide B can pass through the brain-blood barrier. Ginkgolide B has anti-oxidant, anti-inflammatory, anti-tumor, and anti-apoptotic activity. Ginkgolide B has marked neuroprotective effects against ischemia-induced impairments .

HY-N0036

Costunolide 5+ Cited Publications (+)-Costunolide; Costus Lactone	Structural Classification Classification of Application Fields Erythrina subumbrans (Hassk.) Merr. Terpenoids Sesquiterpenes Plants Compositae Endogenous metabolite Disease Research Fields Source Classification Cancer	Apoptosis Endogenous Metabolite
Costunolide ((+)-Costunolide) is a naturally occurring sesquiterpene lactone, with antioxidative, anti-inflammatory, antiallergic, bone remodeling, neuroprotective, hair growth promoting, anticancer, and antidiabetic properties. Costunolide can induce cell cycle arrest and apoptosis on breast cancer cells .

HY-N0273

Brassinolide 4 Publications Verification Brassin Lactone	Natural Products other families Classification of Application Fields Brassinolide Plants Phytohormone Disease Research Fields Biological Pesticide Research Source Classification Cancer Agricultural Research	Apoptosis
Brassinolide is a predominant plant growth modulator that regulate plant cell elongation.

HY-N0548

α-Angelica lactone 2 Publications Verification	Natural Products Classification of Application Fields Dicerothamnus rhinocerotis Umbelliferae Plants Disease Research Fields Source Classification Cancer	Glutathione S-transferase
α-Angelica lactone is a naturally occurring anticarcinogen and an vinylogous nucleophile. α-Angelica lactone can give the chiral δ-amino γ,γ-disubstituted butenolide carbonyl derivatives and exhibitselectrophilic trapping at the γ-carbon. α-Angelica lactone exerts strong chemoprotective effects by selective enhancement of glutathione-S-thansferase (GST) and UDP-glucononosyltransferase (UGT) detoxification enzymes .

HY-N0591

Dehydrocostus Lactone 2 Publications Verification (-)-Dehydrocostus Lactone; Epiligulyl oxide	Saussurea costus (Falc.) Lipsch. Classification of Application Fields Terpenoids Sesquiterpenes Plants Compositae Disease Research Fields Cancer	Bacterial Apoptosis p38 MAPK NF-κB MAPKAPK2 (MK2) Akt NO Synthase Interleukin Related Caspase
Dehydrocostus Lactone ((-)-Dehydrocostus lactone) is a natural sesquiterpene that can be isolated from Saussurea lappa. Dehydrocostus Lactone has multiple activities such as anti-inflammatory, antibacterial, anti-tumor, and immunomodulatory effects. Dehydrocostus Lactone has an MIC of 2 µg/mL against Mycobacterium tuberculosis. Dehydrocostus Lactone can also inhibit the killing activity of cytotoxic T lymphocytes and induce apoptosis in tumor cells .

HY-41982

D-Glucuronic acid lactone 1 Publications Verification D-Glucurono-6,3-Lactone; D-Glucurono-γ-Lactone; D-GlucuronoLactone; Dicurone; Glucoxy; GlucuroLactone; Glucurone	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Endogenous Metabolite Drug Derivative
D-Glucuronic acid lactone (D-Glucurono-6,3-lactone; D-Glucurono-γ-lactone; D-Glucuronolactone; Dicurone; Glucoxy; Glucurolactone; Glucurone) is an endogenous metabolite and a glucuronic acid derivative. D-Glucuronic acid lactone serves as a starting reagent for the synthesis of 2,3,4-tris (tert-butyldimethylsilyl) glucuronic acid trichloroethyl ester, which is used to prepare 1-O-acyl glucuronic acids for the anti-inflammatory agent mL-3000 (HY-B1452), synthesize optically active glucuronic acids, and produce long-chain alkyl glucuronides. D-Glucuronic acid lactone shows potential for use in studies of reversible cerebral vasoconstriction syndrome (RCVS) .

HY-136409

N-Decanoyl-L-homoserine lactone C10-HSL	Microorganisms Source Classification	Bacterial Reactive Oxygen Species (ROS)
N-decanoyl-L-homoserine lactone (C10-HSL) is a N-acyl-homoserine lactone (AHL) N-decanoyl-L-homoserine lactone can inhibit primary root growth in Arabidopsis. N-decanoyl-L-homoserine lactone triggers a transient and immediate increase in the concentrations of cytosolic free Ca ²⁺ and reactive oxygen species (ROS), increases the activity of mitogen-activated protein kinase 6 (MPK6), and induces nitric oxide (NO) production in Arabidopsis roots .

HY-I0301

D-(+)-Glucono-1,5-lactone 1 Publications Verification Gluconic acid Lactone	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Saccharides Source Classification	Environmental Pollutants Endogenous Metabolite Reactive Oxygen Species (ROS)
D-(+)-Glucono-1,5-lactone is a polyhydroxy (PHA) that is capable of metal chelating, moisturizing and antioxidant activity.

HY-76691

D-Ribonolactone	Infection Classification of Application Fields Endogenous metabolite Disease Research Fields Saccharides Monosaccharides Source Classification	Endogenous Metabolite Bacterial
D-Ribonolactone is sugar lactone and an inhibitor of β-galactosidase of Escherichia coli with a K_i of 26 mM .

HY-108549

clasto-Lactacystin β-lactone Omuralide; β-Clastolactacystin	Classification of Application Fields Disease Research Fields Cancer	Proteasome
Clasto-Lactacystin β-lactone, a natural active metabolite of lactacystin, which is a metabolite of Streptomyces, acts as an irreversible 20S proteasome inhibitor.

HY-W035362

ω-Pentadecalactone	Structural Classification Natural Products other families Classification of Application Fields Other Diseases Plants Disease Research Fields Source Classification	Environmental Pollutants
ω-Pentadecalactone, a macrocyclic lactone, is a fragrance ingredient. ω-Pentadecalactone is a member of the fragrance structural group macrocyclic lactone and lactide derivative .

HY-N7347

(-)-Hydroxycitric acid lactone Garcinia Lactone	other families Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Plants Disease Research Fields Source Classification	ATP Citrate Lyase
(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis .

HY-W008393

*(-)-Corey lactone* diol**	Classification of Application Fields Other Diseases Disease Research Fields	Drug Intermediate
(-)-Corey lactone diol is the reduced form of Corey aldehyde. (-)-Corey lactone diol can be used as a drug intermediate for the synthesis of Beraprost (HY-13569A) .

HY-N7435

Massoia lactone 1 Publications Verification (±)-Massoia Lactone	Natural Products other families Classification of Application Fields Other Diseases Plants Disease Research Fields Source Classification	Others
Massoia lactone ((±)-Massoia lactone) is a coconut and creamy fragrant compound mianly isolated from Cryptocarya massoy. Massoia lactone is also a fragrant biosurfactant produced by a fungus Aureobasidium pullulans .

HY-N9357

Granilin	Infection Classification of Application Fields Terpenoids Sesquiterpenes Plants Compositae Disease Research Fields Erythrina arborescens Roxb. Source Classification	Bacterial Fungal
Granilin, a sesquiterpene lactone, can be found in the flower buds of Carpesium triste. Granilin can be used as the bactericide and fungicide .

HY-W015891

ε-Caprolactone	Natural Products Rubus arcticus L. Rosaceae Plants Source Classification	Endogenous Metabolite
ε-Caprolactone is a lactone compound that can be isolated from the Arctic thorn .

HY-133683

N-(3-Oxotetradecanoyl)-DL-homoserine lactone 3-Oxo-C14-AHL	Natural Products Microorganisms Classification of Application Fields Metabolic Disease Disease Research Fields Source Classification	Bacterial
N-(3-Oxotetradecanoyl)-DL-homoserine lactone, a member of N-Acyl homoserine lactone (AHL) from gram-negative bacteria, is a quorum sensing (QS) signaling molecule .

HY-W017445

Homogentisic acid lactone	Monophenols Microorganisms Phenols Source Classification	Fungal
Homogentisic acid lactone (Compound 1) is a fungal metabolite with fungicidal activity, which is found in the fungus WF5. Homogentisic acid lactone is active against the plant pathogenic fungus F. graminearum. Homogentisic acid lactone can be used as a substrate in the determination of serum paraoxonase/arylesterase 1 (PON1) activity .

HY-W016628

L-Gulono-1,4-lactone L-GulonoLactone	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides Source Classification	Endogenous Metabolite
L-Gulono-1,4-lactone is a substrate of L-gulono-1,4-lactone oxidoreductase, which catalyzes the last step of the biosynthesis of L-ascorbic (Vatamin) C. In other words, L-Gulono-1,4-lactone is a direct precursor of vitamin C in animals, in plants and in some protists.

HY-N8187

Eupalinolide O	Classification of Application Fields Melilotus albus Desr. Terpenoids Sesquiterpenes Plants Compositae Disease Research Fields Source Classification Cancer	Apoptosis
Eupalinolide O is a sesquiterpene lactone with anticancer activities. Eupalinolide O induces cell apoptosis in human MDA-MB-468 breast cancer cells .

HY-134560

N-(3-Oxodecanoyl)-L-homoserine lactone 3-Oxo-C10-HSL	Microorganisms Ketones, Aldehydes, Acids Source Classification	Bacterial
N-(3-Oxodecanoyl)-L-homoserine lactone (3-Oxo-C10-HSL) is a bacterial quorum sensing signal autoinducer molecule .

HY-N10483

Telekin	Terpenoids Sesquiterpenes Bauhinia thonningii Plants Compositae Source Classification	Apoptosis
Telekin is an eucalyptus-type sesquiterpene lactone compound found in Carpesium divaricatum. Telekin can activate mitochondria-mediated cell apoptosis and has anticancer activity .

HY-122295

Dehydroleucodine	other families Artemisia douglasiana Classification of Application Fields Plants Inflammation/Immunology Disease Research Fields Source Classification	Apoptosis
Dehydroleucodine is a sesquiterpene lactone isolated from Artemisia douglasiana. Dehydroleucodine is a mast cell stabilizer that inhibits tmast cell degranulation induced by compound 48/80. Dehydroleucodine inudces cells apoptosis, and has gastric ulcer inhibition and antileukemic effects .

HY-N7293

Bakkenolide D	Structural Classification Natural Products Valeriana jatamansi Jones Plants Valerianaceae Source Classification	Histamine Receptor
Bakkenolide D is a sesquiterpene lactone. Bakkenolide D is the major component of Bakkenolides in Petasites tricholobus. Bakkenolide D exhibits anti-allergic and antihistamine activities, and can be used in studies related to allergic rhinitis .

HY-N0273R

Brassinolide (Standard) Brassin Lactone (Standard)	Structural Classification Natural Products other families Plants Source Classification	Apoptosis Reference Standards
Brassinolide (Standard) is the analytical standard of Brassinolide. This product is intended for research and analytical applications. Brassinolide is a predominant plant growth modulator that regulate plant cell elongation.

HY-N0036R

Costunolide (Standard) (+)-Costunolide (Standard); Costus Lactone (Standard)	Structural Classification Erythrina subumbrans (Hassk.) Merr. Terpenoids Sesquiterpenes Plants Compositae Endogenous metabolite Source Classification	Reference Standards Apoptosis Endogenous Metabolite
Costunolide (Standard) is the analytical standard of Costunolide. This product is intended for research and analytical applications. Costunolide ((+)-Costunolide) is a naturally occurring sesquiterpene lactone, with antioxidative, anti-inflammatory, antiallergic, bone remodeling, neuroprotective, hair growth promoting, anticancer, and antidiabetic properties. Costunolide can induce cell cycle arrest and apoptosis on breast cancer cells .

HY-N0784R

Ginkgolide B (Standard) BN-52021 (Standard)	Structural Classification Ginkgoaceae Terpenoids Diterpenoids Plants Endogenous metabolite Ginkgo biloba Source Classification	Reference Standards Platelet-activating Factor Receptor (PAFR) Apoptosis
Ginkgolide B (Standard) is the analytical standard of Ginkgolide B. This product is intended for research and analytical applications. Ginkgolide B (BN-52021), a terpene lactone, is a potent platelet activating factor antagonist. Ginkgolide B protects endothelial cells via the activation of PXR from injuries induced by xeno- and endobiotics. Ginkgolide B can pass through the brain-blood barrier. Ginkgolide B has anti-oxidant, anti-inflammatory, anti-tumor, and anti-apoptotic activity. Ginkgolide B has marked neuroprotective effects against ischemia-induced impairments .

HY-N0548R

*α-Angelica lactone* (Standard)**	Structural Classification Natural Products Dicerothamnus rhinocerotis Umbelliferae Plants Source Classification	Glutathione S-transferase Reference Standards
α-Angelica lactone (Standard) is the analytical standard of α-Angelica lactone. This product is intended for research and analytical applications. α-Angelica lactone is a naturally occurring anticarcinogen and an vinylogous nucleophile. α-Angelica lactone can give the chiral δ-amino γ,γ-disubstituted butenolide carbonyl derivatives and exhibitselectrophilic trapping at the γ-carbon. α-Angelica lactone exerts strong chemoprotective effects by selective enhancement of glutathione-S-thansferase (GST) and UDP-glucononosyltransferase (UGT) detoxification enzymes .

HY-N3422

(+)-cis-Khellactone	Olearia paniculata Druce Coumarins Phenylpropanoids Plants Umbelliferae Source Classification	Others
(+)-cis-Khellactone is a lactone, that can be isolated from Cordyceps. (+)-cis-Khellactone has potential medicinal properties, including anti-inflammatory, vasodilator and spasmolytic effects .

HY-N6955

Eupalinilide B	Classification of Application Fields Melilotus albus Desr. Terpenoids Sesquiterpenes Plants Compositae Disease Research Fields Source Classification Cancer	Others
Eupalinilide B is a guaiane type sesquiterpene lactone that can be found in Eupatorium lindleyanum. Eupalinilide B shows potent cytotoxicity against P-388 and A-549 tumor cell lines .

HY-N8619

Minimolide F 1 Publications Verification	Terpenoids Sesquiterpenes Euchresta horsfieldii (Lesch.) J. Benn. Plants Compositae	Others
Minimolide F is a sesquiterpene lactone. Minimolide F has inhibitory activity against human nasopharyngeal cancer cells. Minimolide F can be used for the research of cancer .

HY-N10073

Eupahualin C	Terpenoids Sesquiterpenes Plants Compositae Erythrina herbacea Source Classification	Others
Eupahualin C is a sesquiterpene lactone that can be isolated from Eupatorium hualienense. Eupahualin C shows cytotoxicity to K562 and U2OS cancer cells .

HY-N2277

3β,7β,15β-Trihydroxy-11-oxo-lanosta-8-en-24→20 lactone	Triterpenes Structural Classification Tetracyclic Triterpenoids Classification of Application Fields Terpenoids Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Inflammation/Immunology Disease Research Fields Source Classification	Bacterial
3β,7β,15β-Trihydroxy-11-oxo-lanosta-8-en-24→20 lactone is a natural compound that could be isolated from G. lucidum with antimycobacterial activity.

HY-N16658

Asperilin NSC 85238	Structural Classification Terpenoids Sesquiterpenes Plants Compositae Oparanthus teikiteetinii (J.Florence & Stuessy) R.K.Shannon & W.L.Wagner Source Classification	Glutathione Peroxidase
Asperilin (NSC 85238) is an orally active sesquiterpene lactone. Asperilin is an effective hydroxyl radical scavenger. Asperilin significantly enhance the lipid peroxidation levels of liver microsomes in various systems. Asperilin leads to a significant decrease in liver glutathione (GSH) levels and an increase in glutathione peroxidase (GPx) activity. Asperilin can be used for research on inflammatory conditions .

HY-113801

N-(3-Oxooctanoyl)-DL-homoserine lactone (Rac)-3-oxo-C8-HSL	Natural Products Microorganisms Classification of Application Fields Metabolic Disease Disease Research Fields Source Classification	Endogenous Metabolite
N-(3-Oxooctanoyl)-DL-homoserine lacton is a member of N-Acyl homoserine lactone (AHL) from gram-negative bacteria, with stereochemistry-dependent growth regulatory activity for roots .

HY-125678

Jasmine lactone	Natural Products Oleaceae Ketones, Aldehydes, Acids Jasminum sambac (L.) Aiton Plants Source Classification	Others
Jasmine lactone, a volatile substance produced by plants under stress, has a strong odor and is known for its unique jasmine-like floral and fruity scent which is very popular in tea, especially in oolong and black tea. The biosynthesis mechanism of Jasmine lactone in tea is regulated by various stresses, including mechanical damage and low temperature stress. Continuous mechanical damage and low temperature and mechanical damage can enhance the accumulation of Jasmine lactone in tea .

HY-W035362R

ω-Pentadecalactone (Standard)	Structural Classification Natural Products other families Plants Source Classification	Biochemical Assay Reagents Reference Standards
ω-Pentadecalactone, a macrocyclic lactone, is a fragrance ingredient. ω-Pentadecalactone is a member of the fragrance structural group macrocyclic lactone and lactide derivative .

HY-122915

Zedoarondiol	Terpenoids Sesquiterpenes Plants Curcuma aromatica Salisb. Source Classification Zingiberaceae	Reactive Oxygen Species (ROS)
Zedoarondiol, a sesquiterpene lactone compound, with antioxidant and anti-inflammatory activity. Zedoarondiol can be used for atherosclerosis research .

HY-N1814

3β-Hydroxyurs-11-en-28,13β-olide 11,12-Dehydroursolic acid Lactone	Triterpenes Fadogia tetraquetra var. tetraquetra Terpenoids Rubiaceae Plants Source Classification	Bacterial
3β-Hydroxyurs-11-en-28,13β-olide (11,12-Dehydroursolic acid lactone) is a triterpenoid that can be found in Fadogia tetraquetra var. tetraquetra . 3β-Hydroxyurs-11-en-28,13β-olide shows antibacterial activity .

HY-P1709

Protactin	Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial
Protactin is a pentapeptide lactone produced by Streptomyces cucumeris strain L703-4 (ATCC 53784) with significant antioxidant properties. Protactin can be converted to actinomycin Zp by ferrocyanide oxidation. Actinomycin Zp exhibits potent antibacterial activity in vitro and has significant antitumor effects against P-388 leukemia in a mouse model .

HY-133683R

*N-(3-Oxotetradecanoyl)-DL-homoserine lactone* (Standard)** 3-Oxo-C14-AHL (Standard)	Natural Products Microorganisms Source Classification	Bacterial Reference Standards
N-(3-Oxotetradecanoyl)-DL-homoserine lactone (Standard) is the analytical standard of N-(3-Oxotetradecanoyl)-DL-homoserine lactone. This product is intended for research and analytical applications. N-(3-Oxotetradecanoyl)-DL-homoserine lactone, a member of N-Acyl homoserine lactone (AHL) from gram-negative bacteria, is a quorum sensing (QS) signaling molecule[1][2].

HY-N7347R

*(-)-Hydroxycitric acid lactone* (Standard)** Garcinia Lactone (Standard)	other families Ketones, Aldehydes, Acids Plants Source Classification	Reference Standards ATP Citrate Lyase
(-)-Hydroxycitric acid lactone (Standard) is the analytical standard of (-)-Hydroxycitric acid lactone. This product is intended for research and analytical applications. (-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis .

HY-I0301R

*D-(+)-Glucono-1,5-lactone* (Standard)** Gluconic acid Lactone (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Saccharides Source Classification	Reference Standards Endogenous Metabolite Reactive Oxygen Species (ROS)
D-(+)-Glucono-1,5-lactone (Standard) is the analytical standard of D-(+)-Glucono-1,5-lactone. This product is intended for research and analytical applications. D-(+)-Glucono-1,5-lactone is a polyhydroxy (PHA) that is capable of metal chelating, moisturizing and antioxidant activity.

HY-N0591R

*Dehydrocostus Lactone* (Standard)** (-)-Dehydrocostus Lactone (Standard); Epiligulyl oxide (Standard)	Saussurea costus (Falc.) Lipsch. Structural Classification Terpenoids Sesquiterpenes Plants Compositae	Reference Standards Bacterial Apoptosis p38 MAPK NF-κB MAPKAPK2 (MK2) Akt NO Synthase Interleukin Related Caspase
Dehydrocostus Lactone (Standard) ((-)-Dehydrocostus lactone (Standard)) is the analytical standard of Dehydrocostus Lactone (HY-N0591). This product is intended for research and analytical applications. Dehydrocostus Lactone is a natural sesquiterpene that can be isolated from Saussurea lappa. Dehydrocostus Lactone has multiple activities such as anti-inflammatory, antibacterial, anti-tumor, and immunomodulatory effects. Dehydrocostus Lactone has an MIC of 2 µg/mL against Mycobacterium tuberculosis. Dehydrocostus Lactone can also inhibit the killing activity of cytotoxic T lymphocytes and induce apoptosis in tumor cells.

HY-41982R

*D-Glucuronic acid lactone* (Standard)** D-Glucurono-6,3-Lactone (Standard); D-Glucurono-γ-Lactone (Standard); D-GlucuronoLactone (Standard); Dicurone (Standard); Glucoxy (Standard); GlucuroLactone (Standard); Glucurone (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
D-Glucuronic acid lactone (Standard) is the analytical standard of D-Glucuronic acid lactone. This product is intended for research and analytical applications. D-Glucuronic acid lactone is an endogenous metabolite.

HY-N9292

Friedelin-3,4-lactone	Triterpenes Terpenoids Euphorbiaceae Plants Garcia parviflora Lundell Source Classification	Others
Friedelin-3,4-lactone (Compound 4) is a triterpene can be isolated from the leaves of Garcia parViflora with weak antitumor activity .

HY-N13712

Lucidenic lactone	Other Terpenoids Structural Classification Microorganisms Terpenoids Source Classification	DNA/RNA Synthesis HIV Reverse Transcriptase
Lucidenic lactone is a terpene compound, is a DNA polymerase inhibitor. Lucidenic lactone inhibits calf DNA polymerase-α, rat DNA polymerase-β, and HIV-1 reverse transcriptase with IC₅₀ values of 42 μM, 99 μM, and 69 μM, respectively .

HY-N8832

Matsukaze-lactone	Boenninghausenia albiflora (Hook.) Reichb. ex Meisn. Rutaceae Coumarins Phenylpropanoids Plants Source Classification	Others
Matsukaze-lactone is a Coumarins product that can be isolated from the leaves of Boenninghausenia albiflora. .

HY-W145487

D-Xylono-1,4-lactone	Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Biochemical Assay Reagents Endogenous Metabolite
D-Xylono-1,4-lactone is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W016628R

*L-Gulono-1,4-lactone* (Standard)** L-GulonoLactone (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Saccharides Source Classification	Reference Standards Endogenous Metabolite
L-Gulono-1,4-lactone (L-Gulonolactone) (Standard) is the analytical standard of L-Gulono-1,4-lactone. This product is intended for research and analytical applications. L-Gulono-1,4-lactone is a biosynthetic precursor of L-Ascorbic acid (Vitamin C) (HY-B0166). L-Gulono-1,4-lactone can be enzymatically converted to L-Ascorbic acid via the animal uronic acid pathway, while species such as humans lack the key oxidase that catalyzes this step, resulting in the disruption of this pathway and the necessity to obtain Vitamin C from diet. L-Gulono-1,4-lactone is a putative intermediate in an alternative biosynthetic pathway of L-Ascorbic acid in Arabidopsis thaliana.

Cat. No.	Product Name	Chemical Structure

HY-13756S

Tacrolimus-13C,d2 1 Publications Verification
Tacrolimus- ¹³C,d₂ is a ¹³C-labeled and deuterium labeled Tacrolimus. Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .

HY-13756S2

Tacrolimus-d3
Tacrolimus-d₃ (FK506-d₃) is deuterium labeled Tacrolimus. Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .

HY-107855S

DL-Mevalonolactone-d7
DL-Mevalonolactone-d₇ is the deuterium labeled DL-Mevalonolactone. DL-Mevalonolactone ((±)-Mevalonolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential (?Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling .

HY-133685S

*N-Hexanoyl-L-Homoserine lactone-d3*
N-Hexanoyl-L-Homoserine lactone-d₃ (C6-HSL-d₃) is deuterium labeled N-Hexanoyl-L-homoserine lactone. N-Hexanoyl-L-homoserine lactone is a short-chained N-acyl homoserine lactone (AHL). Diatoms are frequently found in association with Proteobacteria, many members of which employ cell-to-cell communication via AHLs in aquatic habitats .

HY-B0094S

Artemisinin-d3

Artemisinin-d₃ is the deuterium labeled Artemisinin. Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants . Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects .

HY-101873S

*Atorvastatin lactone-d5*
Atorvastatin lactone-d₅ is a deuterated form of Atorvastatin lactone (HY-101873). Atorvastatin lactone is a proagent form of atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor .

HY-122402S

Umirolimus-d5
Umirolimus-d₅ is the deuterium labeled Umirolimus (HY-122402). Umirolimus, a macrocyclic triene lactone Rapamycin derivative, is powerful immunosuppressant and anti-inflammatory agent. Umirolimus has highly lipophilicity and can be used agent-eluting stent (DES) applications .

HY-I0301S

*D-(+)-Glucono-1,5-lactone-1-13C*
D-(+)-Glucono-1,5-lactone-1- ¹³C is the ¹³C labeled D-(+)-Glucono-1,5-lactone. D-(+)-Glucono-1,5-lactone is a polyhydroxy (PHA) that is capable of metal chelating, moisturizing and antioxidant activ .

HY-117068S

*(R)-Bromoenol lactone-d7*
(R)-Bromoenol lactone-d₇ ((R,E)-Bromoenol lactone-d₇) is deuterium labeled (R)-Bromoenol lactone. (R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase γ (iPLA2γ). (R)-BEL inhibits human recombinant iPLA2γ with an IC₅₀ of approximately 0.6 μM .

HY-W768262

*D-(+)-Glucono-1,5-lactone-13C6*
D-(+)-Glucono-1,5-lactone- ¹³C₆ (Gluconic acid lactone- ¹³C₆) is the ¹³C-labeled D-(+)-Glucono-1,5-lactone (HY-I0301). D-(+)-Glucono-1,5-lactone is a polyhydroxy (PHA) that is capable of metal chelating, moisturizing and antioxidant activity.

HY-138166S

Rosuvastatin lactone-d6

Rosuvastatin lactone-d₆ is the deuterium labeled Rosuvastatin lactone. Rosuvastatin lactone is a metabolite of Rosuvastatin (HY-17504A), a statin lipid-lowering agent and HMG-CoA inhibitor. Rosuvastatin lactone exhibits endothelium-independent and HMG-CoA reductase-independent vasorelaxant activity in rat aortic rings, and its vasorelaxant effect is jointly mediated by NO produced by inducible nitric oxide synthase (iNOS) located in vascular smooth muscle and activation of potassium channels. Rosuvastatin lactone itself has no lipid-lowering effect .

HY-125678S

Jasmine lactone-d2

Jasmine lactone-d₂ is deuterated labeled Jasmine lactone (HY-125678). Jasmine lactone, a volatile substance produced by plants under stress, has a strong odor and is known for its unique jasmine-like floral and fruity scent which is very popular in tea, especially in oolong and black tea. The biosynthesis mechanism of Jasmine lactone in tea is regulated by various stresses, including mechanical damage and low temperature stress. Continuous mechanical damage and low temperature and mechanical damage can enhance the accumulation of Jasmine lactone in tea .

HY-120986S

*(S)-Bromoenol lactone-d7*
(S)-Bromoenol lactone-d₇ is the deuterium labeled (S)-Bromoenol lactone .

HY-136346S

*Ortho-hydroxy atorvastatin lactone-d5*
Ortho-hydroxy atorvastatin lactone-d₅ is deuterium labeled 2-Hydroxy atorvastatin lactone. 2-Hydroxy atorvastatin lactone is a metabolite of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids .

HY-114816S

N-butyryl-L-Homoserine lactone-d5

N-butyryl-L-Homoserine lactone-d₅ is the deuterium labeled N-Butanoyl-L-homoserine lactone. N-Butanoyl-L-homoserine lactone (C4-HSL) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm . N-Butanoyl-L-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa .

HY-W699829

*(3R,5R)-Rosuvastatin Lactone-d6*
(3R,5R)-Rosuvastatin Lactone-d₆ is the deuterium labeled (3R,5R)-Rosuvastatin Lactone (HY-135406). (3R,5R)-Rosuvastatin Lactone is an isomer of Rosuvastatin Lactone.

HY-W768934

*L-Gulono-1,4-lactone-13C6*
L-Gulono-1,4-lactone- ¹³C₆ (L-Gulonolactone- ¹³C₆) is the ¹³C-labeled L-Gulono-1,4-lactone (HY-W016628). L-Gulono-1,4-lactone is a substrate of L-gulono-1,4-lactone oxidoreductase, which catalyzes the last step of the biosynthesis of L-ascorbic (Vatamin) C. In other words, L-Gulono-1,4-lactone is a direct precursor of vitamin C in animals, in plants and in some protists.

HY-150980S

1,2-O-Isopropylidene-β-L-idofuranuronic-6-13C acid γ-lactone
1,2-O-Isopropylidene-β-L-idofuranuronic-6- ¹³C acid γ-lactone is the ¹³C labeled 1,2-O-Isopropylidene-β-L-idofuranuronic acid γ-lactone .

HY-W742150

*4-Dehydroxy-3-dehydro-pitavastatin lactone-d5*
4-Dehydroxy-3-dehydro-pitavastatin lactone-d₅ is the deuterium labeled (S,E)-6-(2-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)vinyl)-5,6-dihydro-2H-pyran-2-one (Pitavastatin Impurity） (HY-Z3610).

HY-150981S

1,2-O-Isopropylidene-a-D-glucofuranuronic-6-13C acid, γ-lactone
1,2-O-Isopropylidene-a-D-glucofuranuronic-6- ¹³C acid, γ-lactone is the ¹³C labeled 1,2-O-Isopropylidene-β-L-idofuranuronic acid, γ-lactone .

HY-W765182

Emamectin-d3
Emamectin-d₃ is the deuterium labeled Emamectin. Emamectin is a macrocyclic lactone insecticide. Emamectin acts as agonist for GABA-gated chloride channels .

HY-165668S

*Pitavastatin lactone-d4*
Pitavastatin lactone-d₄ (6S-((E)-2-(2-Cyclopropyl-4-(4-fluorophenyl-2,3,5,6-d₄)quinolin-3-yl)vinyl)-4R-hydroxytetrahydro-2H-pyran-2-one) is deuterium labeled Pitavastatin lactone .

HY-W010305S

5-Ethyl-3-hydroxy-4-methylfuran-2(5H)-one-d4
5-Ethyl-3-hydroxy-4-methylfuran-2(5H)-one-d₄ is deuterated labeled 5-Ethyl-3-hydroxy-4-methylfuran-2(5H)-one.

HY-W017562S

γ-Octalactone-d7
γ-Octalactone-d₇ is deuterated labeled γ-Octalactone (HY-W017562). γ-Octalactone is an aromatic lactone compound. γ-Octalactone has a strong fruity (similar to coconut) aroma and a sweet taste, and is commonly used in food, cosmetics and fragrances. γ-Octalactone is highly safe.

HY-107855S1

DL-Mevalonolactone-d3

DL-Mevalonolactone-d₃ is the deuterium labeled DL-Mevalonolactone . DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential ( Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling .

HY-119695AS

Simvastatin acid-d6 ammonium

Simvastatin acid-d₆ (ammonium)mis the deuterium labeled Simvastatin acid ammonium. Simvastatin ammonium is an active metabolite of simvastatin lactone mediated by CYP3A4/5 in the intestinal wall and liver (pKa=5.5). Simvastatin ammonium reduces indoxyl sulfate-mediated reactive oxygen species and modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene .

HY-B0094S3

Artemisinin-13C,d4

Artemisinin- ¹³C,d₄ is ¹³C and deuterated labeled Artemisinin (HY-B0094). Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants . Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects .

HY-B1118S2

Secnidazole-d4

Secnidazole-d₄ is the deuterium labeled Secnidazole . Secnidazole (RP-14539) is an orally active azole antibiotic and a imidazole mitigator of Serratia marcescens virulence. Secnidazole, as an analog of acylhomoserine lactones, effectively inhibits QS resulting in the attenuation of Pseudomonas aeruginosa pathogenesis. Secnidazole has antimicrobial activity against many anaerobic Gram-negative and Gram-positive bacterial species in vitro. Secnidazole can be used for the research of various diseases, such as amoebiasis and giardiasis, and bacterial vaginitis .

HY-B1118S3

Secnidazole-d3

Secnidazole-d₃ (RP-14539-d₃; PM-185184-d₃) is the deuterium labeled Secnidazole (HY-B1118). Secnidazole (RP-14539) is an orally active azole antibiotic and a imidazole mitigator of Serratia marcescens virulence. Secnidazole, as an analog of acylhomoserine lactones, effectively inhibits QS resulting in the attenuation of Pseudomonas aeruginosa pathogenesis. Secnidazole has antimicrobial activity against many anaerobic Gram-negative and Gram-positive bacterial species in vitro. Secnidazole can be used for the research of various diseases, such as amoebiasis and giardiasis, and bacterial vaginitis .

HY-121795S

*Pravastatin lactone-d3*
Pravastatin Lactone-d₃ is the deuterium labeled Pravastatin Lactone .

HY-126852S

*4-Hydroxy Atorvastatin lactone-d5*
4-Hydroxy Atorvastatin lactone-d₅ is deuterium labeled 4-hydroxy Atorvastatin lactone.

HY-132552S

*(-)-Corey lactone-heptyldioxolane-d15*
(-)-Corey lactone-heptyldioxolane-d₁₅ is the deuterium labeled (-)-Corey lactone-heptyldioxolane .

HY-132319S

*(-)-Corey lactone* diol-heptyldioxolane-d15**
(-)-Corey lactone diol-heptyldioxolane-d₁₅ is the deuterium labeled (-)-Corey lactone diol-heptyldioxolane .

HY-W587796S

*6-Phosphoglucono-d-lactone-13C6*
6-Phosphoglucono-d-lactone- ¹³C₆ (6-PGδL- ¹³C₆) is the ¹³C-labeled 6-Phosphoglucono-d-lactone.

HY-W752587

DL-Mevalonolactone-d4

DL-Mevalonolactone-d₄ ( (±)-Mevalonolactone-d₄) is the deuterium labeled DL-Mevalonolactone (HY-107855). DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone is orally active against HMGCR mutation and statin caused myopathy . DL-Mevalonolactone induces inflammation and oxidative stress response with decreased mitochondrial membrane potential (MMP) and induces mitochondrial swelling .

Cat. No.	Product Name		Classification

HY-W701862

5-Azido-6-(tert-butyldimethylsilyl)-2,3-O-isopropylidene L-gulono-1,4-lactone		Azide
5-Azido-6-(tert-butyldimethylsilyl)-2,3-O-isopropylidene L-gulono-1,4-lactone is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .

HY-124503

Longanlactone		Alkynes
Longanlactone is a natural pyrrole-lactone alkaloid that can be used as a neurotrophic agent. Longanlactone increases BDNF gene expression in neuro2a cells .

Cat. No.	Product Name		Classification

HY-W018604

2,3,5-Tri-O-benzyl-D-ribono-1,4-lactone		Nucleoside Analogs
2,3,5-Tri-O-benzyl-D-ribono-1,4-lactone is a purine nucleoside analog. 2,3,5-Tri-O-benzyl-D-ribono-1,4-lactone can be synthesized from D-ribose by reacting with methanol under Fischer glycosylation conditions. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. 2,3,5-Tri-O-benzyl-D-ribono-1,4-lactone exerts anticancer activities through inhibition of DNA synthesis, induction of apoptosis, etc. 2,3,5-Tri-O-benzyl-D-ribono-1,4-lactone can be studied in anticancer research for lymphoid malignancies .

HY-154218

2-O-Benzoyl-3-O-t-butyldiphenylsilyl-L-threono lactone		Nucleoside Analogs
2-O-Benzoyl-3-O-t-butyldiphenylsilyl-L-threono lactone is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

HY-154154

3,5-Bis-O-(4-methylbenzoyl)-2-C-methyl-D-ribonic acid gama-lactone		Nucleoside Analogs
3,5-Bis-O-(4-methylbenzoyl)-2-C-methyl-D-ribonic acid gama-lactone is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

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