Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
822 Results for "
PDEs
" in MedChemExpress (MCE) Product Catalog:
Products (822)
822 Results for "PDEs" in MCE Product Catalog:
87
87 Publications Verification
Synonyms: 3-Isobutyl-1-methylxanthine; Isobutylmethylxanthine
Target:
Research Areas:
IBMX is a broad-spectrum phosphodiesterase (PDE) inhibitor, with IC50s of 6.5, 26.3 and 31.7 μM for PDE3, PDE4 and PDE5, respectively.
38
Target:
Phosphodiesterase (PDE) PKA NF-κB Toll-like Receptor (TLR) MyD88 NOD-like Receptor (NLR) Apoptosis NO Synthase COX Interleukin Related TNF Receptor Caspase
Research Areas:
Milrinone (Win 47203) is a selective PDE3 inhibitor with positive inotropic and vasodilatory effects. Milrinone inhibits cAMP hydrolysis and increases intracellular cAMP and PKA signaling. Milrinone reduces NF-κB, TLR4/MyD88, and NLRP3 inflammasome signaling and pro-inflammatory cytokine production, and has antioxidant and anti-apoptotic effects. Milrinone can be used in research on ischemia/reperfusion injury, sepsis, noise-induced hearing loss, acute lung injury, and Alzheimer's disease .
38
Target:
Phosphodiesterase (PDE) PKA NF-κB Toll-like Receptor (TLR) MyD88 NOD-like Receptor (NLR) Apoptosis NO Synthase COX Interleukin Related TNF Receptor Caspase
Research Areas:
Milrinone lactate (Win 47203 lactate) is a selective PDE3 inhibitor with positive inotropic and vasodilatory effects. Milrinone lactate inhibits cAMP hydrolysis and increases intracellular cAMP and PKA signaling. Milrinone lactate reduces NF-κB, TLR4/MyD88, and NLRP3 inflammasome signaling and pro-inflammatory cytokine production, and has antioxidant and anti-apoptotic effects. Milrinone lactate can be used in research on ischemia/reperfusion injury, sepsis, noise-induced hearing loss, acute lung injury, and Alzheimer's disease .
31
Category:
Cardiovascular Disease Flavonols Anti-aging Plant Flavonoids Monophenols Epimedium brevicornu Maxim. Extract Phenols Disease Research Fields Inflammation/Immunology Berberidaceae Extract Cancer
Target:
20
20 Cited Publications
Synonyms: UK-92480 citrate
Research Areas:
Sildenafil citrate is a potent phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 5.22 nM.
20
Research Areas:
Sildenafil (UK-92480) is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM.
20
20 Cited Publications
Cat. No.: HY-16900
CAS No.: 61413-54-5
Synonyms: (R,S)-Rolipram; (±)-Rolipram; ZK 62711
Research Areas:
Rolipram is a PDE4 inhibitor, with blood-brain barrier permeability, that reverses β-amyloid-induced learning and memory impairment in rats. Rolipram elevates intracellular cAMP and clevels and regulates the cAMP/CREB signaling pathway, thereby alleviating neuroinflammation and apoptotic responses. Rolipram promotes neuronal differentiation of human bone marrow mesenchymal stem cells and inhibits Methamphetamine- and morphine-induced hyperlocomotion in mice. Rolipram also reduces the viability of glioblastoma stem-like cells and enhances Bevacizumab (HY-P9906)-induced cell death. Rolipram inhibits the expression of proinflammatory cytokines and enhances central noradrenergic transmission. Rolipram is mainly used in studies related to various central nervous system diseases including Alzheimer's disease, major depressive disorder, glioblastoma multiforme, and multiple sclerosis .
17
17 Cited Publications
Synonyms: APTA-2217; BYK 20869; B9302-107
Target:
Research Areas:
Roflumilast (APTA-2217) is a selective PDE4 inhibitor with IC50s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDE4A4, PDE4B1, and PDE4B2, respectively, without affecting PDE1, PDE2, PDE3 or PDE5 isoenzymes from various cells.
15
15
14
14 Cited Publications
Target:
Research Areas:
PF-04957325 is a highly potent and selective PDE8 inhibitor, with IC50s of 0.7 nM and 0.3 nM for PDE8A and PDE8B, respectively.
14
Category:
Target:
12
Target:
Research Areas:
Dipyridamole is an orally active phosphodiesterase (PDE) inhibitor. Dipyridamole also is an antiplatelet agent used in secondary prophylaxis against stroke. Dipyridamole can induce cancer cell-specific apoptosis .
12
12 Cited Publications
Synonyms: 1,3-Dimethylxanthine monohydrate; Theo-24 monohydrate
11
Target:
Research Areas:
Tadalafil (IC-351) is a PDE5 inhibitor with an IC50 value of 1.8 nM.
11
Target:
Research Areas:
Ibudilast (KC-404; AV-411; MN-166) is a cyclic AMP phosphodiesterase (PDE) inhibitor. Ibudilast has platelet anti-aggregatory effects. Ibudilast can be used for the research of asthma for its inhibitory effects on tracheal smooth muscle contractility. Ibudilast may be a useful neuroprotective and anti-dementia agent counteracting neurotoxicity in activated microglia .
10
Research Areas:
Apremilast (CC-10004) is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC50 of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC50 of 104 nM .
9
9 Cited Publications
Synonyms: Ethyl apovincaminate
Category:
Cardiovascular Disease Catharanthus roseus (L.) G. Don Extract Neurological Disease Anti-aging Indole Alkaloids Apocynaceae Extract Alkaloids Piperidine Alkaloids Plant Disease Research Fields Cancer
Target:
8
8 Cited Publications
7
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
