210 Results for "

RAW 264.7 macrophage

" in MedChemExpress (MCE) Product Catalog:
Products (210)

210 Results for "RAW 264.7 macrophage" in MCE Product Catalog:

162
JSH-23
JSH-23
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162 Publications Verification
Cat. No.: HY-13982
CAS No.: 749886-87-1
Purity:  99.30%
Target:  

NF-κB

Research Areas:  

Metabolic Disease Inflammation/Immunology Cancer

JSH-23 is an NF-κB inhibitor which inhibits NF-κB transcriptional activity with an IC50 of 7.1 μM in lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7. JSH-23 inhibits nuclear translocation of NF-κB p65 without affecting IκBα degradation .
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10
Avicularin
Avicularin
0 Images
10 Cited Publications
Cat. No.: HY-N0222
CAS No.: 572-30-5
Category:  

Flavonols Flavonoids Phenols Polyphenols Plants Lauraceae Disease Research Fields Inflammation/Immunology Lindera aggregata (Sims) Kosterm.

Target:  

COX NF-κB PPAR ERK GLUT Apoptosis

Avicularin is an orally active flavonoid. Avicularin inhibits NF-κB (p65), COX-2 and PPAR-γ activities. Avicularin has anti-inflammatory, anti-infectious anti-allergic, anti-oxidant, hepatoprotective, and anti-tumor activities .
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3
Ergolide
Ergolide
0 Images
3 Cited Publications
Cat. No.: HY-N6893
CAS No.: 54999-07-4
Category:  

Phyllodium pulchellum (L.) Desv. Ketones, Aldehydes, Acids Plants Compositae Disease Research Fields Inflammation/Immunology Piptanthus nepalensis (Hook.) D. Don

Target:  

NF-κB NOD-like Receptor (NLR) Apoptosis Autophagy

Ergolide is an orally active dual inhibitor targeting NF-κB/p65 and NLRP3. Ergolide blocks the NF-κB signaling pathway and the nuclear translocation of p65, and irreversibly binds to the NACHT domain of NLRP3 to inhibit inflammasome assembly. Ergolide significantly reduces the production of inflammatory mediators (e.g., NO, PGE2) and cytokines, induces cancer cell apoptosis, autophagy and ROS generation. Ergolide also enhances the anti-tumor effect of vincristine. Ergolide alleviates acute lung injury via an NLRP3-dependent mechanism, and effectively improves the survival rate and behavioral function of septic mice and inflammatory zebrafish models. Ergolide is used in the research of metastatic uveal melanoma, neurodegenerative diseases (such as Alzheimer's disease, Parkinson's disease), sepsis and acute lymphoblastic leukemia .
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2
Madecassic acid
Madecassic acid
0 Images
2 Cited Publications
Cat. No.: HY-N0569
CAS No.: 18449-41-7
Category:  

Triterpenes Terpenoids Centella asiatica (L.) Urb. Plants Umbelliferae Disease Research Fields Inflammation/Immunology

Target:  

NO Synthase COX TNF Receptor Interleukin Related

Madecassic acid is isolated from Centella asiatica (Umbelliferae). Madecassic acid has anti-inflammatory properties caused by iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 inhibition via the downregulation of NF-κB activation in RAW 264.7 macrophage cells .
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2
Tormentic acid
Tormentic acid
0 Images
2 Cited Publications
Cat. No.: HY-N4137
CAS No.: 13850-16-3
Category:  

Cardiovascular Disease Triterpenes Terpenoids Rosaceae Plants Disease Research Fields Rosa rugosa Thunb.

Target:  

Others

Tormentic acid, a triterpene isolated from Rosa rugosa, exerts anti-inflammatory, antihyperlipidemic, and anti-atherogenic properties .
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2
Brazilein
Brazilein
0 Images
2 Cited Publications
Cat. No.: HY-N10424
CAS No.: 600-76-0
Category:  

Leguminosae Caesalpinia sappan L. Pigments Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology Food Research

Target:  

Na+/K+ ATPase Apoptosis Interleukin Related NO Synthase Bacterial Parasite

Brazilein is a compound with anti-inflammatory and neuroprotective activities, with an IC50 of 500 μM against guinea pig Na +,K +-ATPase. Brazilein reduces iNOS mRNA expression, thereby inhibiting nitric oxide production in immune cells. Brazilein suppresses inflammatory responses by reducing the mRNA expression of TNF-α and IL-6, but has no effect on IL-1β expression. Brazilein reduces the cerebral infarction volume and improves the neurological function scores of rats with cerebral ischemia-reperfusion injury. Brazilein induces apoptosis of splenic lymphocytes in mice. Brazilein inhibits humoral immune responses in mice, and causes thymus and spleen atrophy as well as body weight loss in mice. Brazilein also possesses antimalarial and antibacterial activities. Brazilein is also a red dye. Brazilein can be used in studies related to the infection, nervous system, cardiovascular system and inflammatory diseases .
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1
Dactylorhin A
Dactylorhin A
0 Images
1 Cited Publications
Cat. No.: HY-125531
CAS No.: 256459-34-4
Purity:  98.22%
Category:  

Bletilla striata (Thunb. ex Murray) Rchb. f. Orchidaceae Ketones, Aldehydes, Acids Other Diseases Plants Disease Research Fields

Target:  

Others

Dactylorhin A, a succinate derivative ester, is isolated from rhizomes of Gymnadenia conopsea. Dactylorhin A exhibits moderate inhibitory effects on NO production effects in RAW 264.7 macrophage cells .
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1
Coniferaldehyde
Coniferaldehyde
0 Images
1 Cited Publications
Cat. No.: HY-N2535
CAS No.: 458-36-6
Synonyms: 4-Hydroxy-3-methoxycinnamaldehyde
Category:  

other families Monophenols Simple Phenylpropanols Phenols Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology

Target:  

Keap1-Nrf2 Apoptosis

Coniferaldehyde (4-Hydroxy-3-methoxycinnamaldehyde) is an effective inducer of heme oxygenase-1 (HO-1). Coniferaldehyde inhibits LPS-induced apoptosis through the PKCα/β II/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells. Coniferaldehyde has antioxidant and anti-inflammatory activities .
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1
L6H21
L6H21
0 Images
1 Cited Publications
Cat. No.: HY-W082785A
CAS No.: 24533-47-9
Target:  

TNF Receptor Interleukin Related Toll-like Receptor (TLR) NF-κB NOD-like Receptor (NLR) Apoptosis Caspase Bcl-2 Family Reactive Oxygen Species (ROS)

Research Areas:  

Neurological Disease Metabolic Disease Inflammation/Immunology

L6H21, a Chalcone (HY-121054) derivative, is an orally active, potent and specific myeloid differentiation 2 (MD-2) inhibitor. L6H21 directly binds to MD-2 protein with a high affinity and low KD value of 33.3 μM, blocking the formation of the LPS-TLR4/MD-2 complex. L6H21 inhibits LPS-induced expression of TNF-α and IL-6 in RAW264.7 macrophages, with IC50 values of 6.58 and 8.59 μM, respectively. L6H21 can be used for alcoholic liver disease, metabolic disturbance and neuroinflammation research .
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1
7,3',4'-Tri-O-methylluteolin
7,3',4'-Tri-O-methylluteolin
0 Images
1 Cited Publications
Cat. No.: HY-N7012
CAS No.: 29080-58-8
Synonyms: 5-Hydroxy-3',4',7-trimethoxyflavone
Category:  

Flavonoids Monophenols Flavones Labiatae Phenols Plants Disease Research Fields Swartzia polyphylla DC. Inflammation/Immunology

Target:  

Lipoxygenase TNF Receptor Interleukin Related COX Fungal Parasite Apoptosis

7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) is a flavonoid with multiple biological activities. 7,3',4'-Tri-O-methylluteolin inhibits soybean lipoxygenase (LOX), with an IC50 value of 23.97 µg/mL. 7,3',4'-Tri-O-methylluteolin possesses anti-inflammatory effects in Lipopolysaccharides (HY-D1056) (LPS)-induced RAW 264.7 macrophages. 7,3',4'-Tri-O-methylluteolin inhibits the binding of MDM2 with p53 and induces apoptosis in MCF-7 breast cancer cells. 7,3',4'-Tri-O-methylluteolin also has antioxidant, antifungal and antitrypanosomal activities .
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1
Isolinderalactone
Isolinderalactone
0 Images
1 Cited Publications
Cat. No.: HY-N3001
CAS No.: 957-66-4
Category:  

Terpenoids Sesquiterpenes Plants Lauraceae Disease Research Fields Lindera aggregata (Sims) Kosterm. Cancer

Target:  

STAT VEGFR Bcl-2 Family Survivin IAP NF-κB Apoptosis Caspase

Isolinderalactone is a sesquiterpene that exhibits anti-cancer, anti-inflammatory, and neuroprotective effects. Isolinderalactone inhibits VEGF expression and tyrosine phosphorylation of VEGFR2. Isolinderalactone decreases viability and induces apoptosis in U-87 glioblastoma (GBM) cells and colorectal cancer (CRC) cells. Isolinderalactone induces G2/M phase cell cycle arrest, ROS generation, pJNK/p38 MAPK activation, in colorectal cancer (CRC) cells. Isolinderalactone blocks LPS (HY-D1056)-induced NF-κB activation while activating Nrf2-HMOX1 signaling in RAW264.7 macrophages. Isolinderalactone improves cognitive dysfunction in APP/PS1 mice. Isolinderalactone can be used for the study of Glioblastoma multiforme (GBM), colorectal cancer, Alzheimer’s disease and acute lung injury .
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1
(R,R)-Secoisolariciresinol diglucoside
(R,R)-Secoisolariciresinol diglucoside
0 Images
1 Cited Publications
Cat. No.: HY-N6937
CAS No.: 158932-33-3
Synonyms: (R,R)-SDG; (R,R)-LGM2605
Category:  

Linum usitatissimum Linn. Linaceae Lignans Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology

Target:  

Free Radical Scavengers DNA/RNA Synthesis Drug Isomer

(R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) is an isomer of Secoisolariciresinol diglucoside (HY-105008). (R,R)-Secoisolariciresinol diglucoside scavenges hydroxyl radicals, peroxyl radicals, and DPPH radicals. (R,R)-Secoisolariciresinol diglucoside reduces γ-ray-induced strand breaks in calf thymus DNA . (R,R)-Secoisolariciresinol diglucoside can be used in studies of oxidant-dependent inflammatory tissue injury .
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1
Alisol F
Alisol F
0 Images
1 Cited Publications
Cat. No.: HY-N0854
CAS No.: 155521-45-2
Category:  

Infection Triterpenes Terpenoids Alisma orinentale (Samuel.) Juz. Plants Alismataceae Disease Research Fields

Target:  

HBV ERK JNK p38 MAPK STAT NF-κB TNF Receptor Interleukin Related NO Synthase COX

Alisol F is a protostane-type triterpenoid with anti-inflammatory and anti-hepatitis B virus activities. Alisol F inhibits LPS (HY-D1056)-induced phosphorylation of ERK, JNK, p38, STAT3 and NF-κB (p65), suppresses the production of NO, IL-6, TNF-α and IL-1β, and also downregulates the levels of iNOS and COX-2. Alisol F reduces the serum alanine aminotransferase and aspartate aminotransferase levels in mice with acute liver injury and ameliorates their liver pathological damage .
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1
Rubiadin-1-methyl ether
Rubiadin-1-methyl ether
0 Images
1 Cited Publications
Cat. No.: HY-N1956
CAS No.: 7460-43-7
Category:  

Quinones Monophenols Anthraquinones Rubiaceae Metabolic Disease Phenols Plants Disease Research Fields Rubia cordifolia L.

Target:  

NF-κB RANKL/RANK Autophagy TGF-β Receptor

Rubiadin-1-methyl ether is an orally potent NF-κB p65 inhibitor and autophagy inhibitor. Rubiadin-1-methyl ether inhibits RANKL-induced phosphorylation and nuclear translocation of p65, suppresses BECN1 transcription, blocks LC3 conversion and autophagosome formation, thereby reducing the levels of BECN1 mRNA and Beclin1 protein. Rubiadin-1-methyl ether inhibits osteoclastogenesis, cell proliferation, macrophage M2 polarization and the TGF-β1 signaling pathway, and effectively alleviates pulmonary inflammation. Rubiadin-1-methyl ether is widely used in research on osteoporosis, pulmonary fibrosis, idiopathic pulmonary fibrosis, acute lung injury and other related diseases .
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1
Alisol A 24-acetate
Alisol A 24-acetate
0 Images
1 Cited Publications
Cat. No.: HY-N0853A
CAS No.: 18674-16-3
Synonyms: Alisol A 24-monoacetate; Alisol A monoacetate
Category:  

Triterpenes Alisma plantago-aquatica Linn. Terpenoids Other Diseases Plants Alismataceae Disease Research Fields

Target:  

AMPK Carnitine Palmitoyltransferase (CPT) Acyltransferase Fatty Acid Synthase (FASN) Acetyl-CoA Carboxylase Bcl-2 Family PPAR Nuclear Factor of activated T Cells (NFAT) PI3K Akt PKA ERK Apoptosis Autophagy

Alisol A 24-acetate (Alisol A monoacetate) is an orally active derivative of protostane-type tetracyclic triterpenoid. Alisol A 24-acetate upregulates the expression of adiponectin, AMPKα, CPT1, and ACOX1; downregulates the expression of SREBP-1c, ACC, FAS, Bcl-2, Bcl-xl, PPAR-γ, perilipin A, and NFATc1; inhibits the activity of PI3K/Akt/mTOR and HMGR; and activates the PKA and ERK signaling pathways. Alisol A 24-acetate regulates cell apoptosis (apoptosis), autophagy (Autophagy, hepatic lipid accumulation, inflammatory response, neuroprotection, MRSA membrane integrity, and osteoclast differentiation. Alisol A 24-acetate can be used in research related to non-alcoholic fatty liver disease, nephrotoxicity, obesity, global cerebral ischemia-reperfusion injury, bacterial infection, and osteoporosis .
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1
Cucurbitacin IIa
Cucurbitacin IIa
0 Images
1 Cited Publications
Cat. No.: HY-N1988
CAS No.: 58546-34-2
Synonyms: Hemslecin A
Category:  

Triterpenes Terpenoids Cucurbitaceae Plants Hemsleya chinensis Cogn. ex Forbes et Hemsl. Disease Research Fields Cancer

Target:  

Survivin Apoptosis EGFR Caspase p38 MAPK Autophagy MEK Raf ERK STAT CaMK

Cucurbitacin IIa (Hemslecin A) is an orally active, blood-brain barrier-permeable EGFR inhibitor with an IC50 of 1.455 nM against human EGFR. Cucurbitacin IIa induces caspase-3-dependent apoptosis, downregulates survivin expression, enhances autophagy levels, disrupts the actin cytoskeleton via actin aggregation, arrests the cell cycle at the G2/M phase, and exerts anti-inflammatory activity by inhibiting the EGFR-MAPK signaling pathway. Cucurbitacin IIa can be used in the research of inflammation-related diseases, depression, and cancers such as non-small cell lung cancer .
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1
Picein
Picein
0 Images
1 Cited Publications
Cat. No.: HY-N8698
CAS No.: 530-14-3
Category:  

Plants Nyssaceae Saccharides

Target:  

SOD Ferroptosis Keap1-Nrf2 Heme Oxygenase (HO) Glutathione Peroxidase

Picein is an antioxidant and anti-inflammatory agent. Picein can be isolated from the leaves of Picrorhiza kurroa. Picein reduces MDA levels and increases the levels of SOD, GPX and TAC. Picein alleviates oxidative stress and promotes bone regeneration in osteoporotic bone defects by inhibiting Ferroptosis (via activation of the Nrf2/HO-1/GPX4 pathway). Picein prevents scopolamine (HY-N0296)-induced passive avoidance memory impairment in rats. Picein can be used in research related to osteoporotic bone defects and Alzheimer's disease .
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Norbergenin
Norbergenin
0 Images
1 Cited Publications
Cat. No.: HY-N9447
CAS No.: 79595-97-4
Category:  

Natural Products other families Phenols Polyphenols Plants

Target:  

Free Radical Scavengers Tyrosine Hydroxylase Reactive Oxygen Species (ROS) Apoptosis NF-κB p38 MAPK STAT

Norbergenin is a polyphenolic isocoumarin derivative. Norbergenin acts as a non-competitive inhibitor of bovine adrenal tyrosine hydroxylase (TH) with a Ki value of 69.6 μM. Norbergenin inhibits lipopolysaccharide-induced inflammatory responses in macrophages by suppressing the activation of NF-κB, MAPK and STAT3, as well as blocking metabolic reprogramming . Norbergenin inhibits aluminum chloride-induced oxidative stress and apoptosis and restores neurocognitive parameters. Norbergenin scavenges ROS through multiple mechanisms and protects cell membranes from lipid peroxidation damage. Norbergenin can be used in research related to Alzheimer's disease, peptic ulcer and arthritis .
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1
SMAP-29
SMAP-29
0 Images
1 Cited Publications
Cat. No.: HY-P2460
CAS No.: 172485-26-6
Target:  

Bacterial Fungal Interleukin Related TNF Receptor

Research Areas:  

Infection Inflammation/Immunology

SMAP‑29 is a cathelicidin antimicrobial peptide with LPS‑binding and anti‑inflammatory properties. SMAP‑29 exerts broad‑spectrum antimicrobial activity against bacteria, fungi and multidrug‑resistant isolates. SMAP‑29 kills pathogens by permeabilizing bacterial membranes, inducing depolarization and cell lysis, and also inhibits inflammatory cytokines while reducing lethality in septic shock and pneumonia models. SMAP-29 can be used for research on bacterial infections, drug-resistant infections, septic shock .
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Liriodendrin
Liriodendrin
0 Images
1 Cited Publications
Cat. No.: HY-N3377
CAS No.: 573-44-4
Category:  

Eucommia ulmoides Oliver Lignans Eucommiaceae Phenylpropanoids Plants

Target:  

HSP NF-κB PI3K Akt Apoptosis Toll-like Receptor (TLR) Endogenous Metabolite

Liriodendrin is an orally effective lignan compound with anti-inflammatory, antioxidant, and anti-platelet aggregation activities. Liriodendrin is isolated and extracted from Sargentodoxae caulis and Linaria vulgaris. Liriodendrin regulates the expression of genes related to inflammation and cellular metabolism by inhibiting the NF-κB, PI3K/Akt, and TLR4 signaling pathways, or by activating the PI3K-DDX18 pathway. Liriodendrin increases the expression of HSF1 and HSP27 without cytotoxicity. Liriodendrin is used in studies on ulcerative colitis, myocardial ischemia-reperfusion injury, sepsis-induced acute lung injury, and chronic endometritis .
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