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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
83 Results for "
antioxidant gene expression
" in MedChemExpress (MCE) Product Catalog:
Products (83)
83 Results for "antioxidant gene expression" in MCE Product Catalog:
644
644 Publications Verification
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ML385 is a potent and selective Nrf2 inhibitor with an IC50 of 1.9 μM. ML385 directly binds to the Neh1 domain of NRF2, interferes with the binding of the MAFG-NRF2 protein complex to the antioxidant response element (ARE) DNA sequence, thereby blocking the expression of downstream target genes of NRF2. ML385 can be used in studies related to adult T-cell leukemia, breast cancer, myocardial ischemia/reperfusion injury, non-small cell lung cancer, esophageal squamous cell carcinoma, head and neck squamous cell carcinoma, and lung squamous cell carcinoma .
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23 Cited Publications
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KI696 is a selective KEAP1/NRF2 protein-protein interaction inhibitor with a human Kd value of 1.3 nM. KI696 acts by competitively occupying the NRF2-binding pocket of the KEAP1 Kelch domain. KI696 blocks KEAP1-mediated ubiquitination and degradation of NRF2, promotes the translocation of NRF2 to the nucleus, activates the expression of downstream antioxidant genes, increases intracellular glutathione levels, and alleviates oxidative stress-induced cell damage and inflammatory cell infiltration in the lungs. KI696 reduces ozone-induced pulmonary oxidative damage and inflammatory cell accumulation in rats, and upregulates pulmonary antioxidant genes. KI696 can be used in research related to chronic obstructive pulmonary disease, oxidative stress and inflammation .
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Category:
Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite
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Human Gut Microbiota Metabolites Natural Products Microorganisms Anti-aging Metabolic Disease Endogenous metabolite Disease Research Fields
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20
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Natural Products Animals Metabolic Disease Plants Other Families Extract Endogenous metabolite Disease Research Fields
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8
8 Cited Publications
Cat. No.: HY-P1934
CAS No.: 14705-60-3
Synonyms: Cyclo(phenylalanylprolyl); A-64863
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7
7 Cited Publications
Synonyms: Methylmaleic acid; Citraconate
2
2 Cited Publications
Synonyms: L-Sulforaphane
2
2 Cited Publications
Cat. No.: HY-N1970
CAS No.: 31721-94-5
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2
2 Cited Publications
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BTZO-1, a chemical probe, binds to Macrophage migration inhibitory factor (MIF) with a Kd value of 68.6 nM, and its binding requires the N-terminal Pro1. BTZO-1 can activate antioxidant response element (ARE)-mediated gene expression and suppress oxidative stress-induced cardiomyocyte apoptosis in vitro .
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1
1 Cited Publications
Cat. No.: HY-B1776AS1
CAS No.: 1313734-84-7
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1
1 Cited Publications
Cat. No.: HY-B1776S
CAS No.: 2514812-10-1
1
1 Cited Publications
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Keap1-Nrf2-IN-14 (compound 20c) is a KEAP1-NRF2 inhibitor that effectively disrupts the KEAP1-NRF2 interaction (IC50=75 nM) with a Kd value of 24 nM for KEAP1. Keap1-Nrf2-IN-14 induces the expression of NRF2 target genes and enhances the downstream antioxidant and anti-inflammatory activities. Keap1-Nrf2-IN-14 can be used in the study of oxidative stress-related inflammation .
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1 Cited Publications
Cat. No.: HY-N3027
CAS No.: 117230-33-8
Category:
Triterpenes Glycine max (L.) merr Terpenoids Metabolic Disease Leguminosae Extract Plants Disease Research Fields
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1
1 Cited Publications
Cat. No.: HY-W754777
CAS No.: 68054-73-9
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IPPD-Q is a p-phenylenediamine quinone and also Environmental pollutant. IPPD-Q can be present in tires, fine particulate matter and urban water bodies. IPPD-Q increases the activities of antioxidant enzymes (SOD, CAT), alters photosynthesis and energy metabolism pathways, and changes gene expression and metabolic profiles. IPPD-Q exhibits phytotoxic effects. IPPD-Q shows acute toxicity to zebrafish embryos and reduces their survival rate .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
