Search Result

Pathways Recommended:	Neuronal Signaling

Results for "

neuronal nitric oxide synthase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	NO Synthase (37) Apoptosis (8) Endogenous Metabolite (7) Estrogen Receptor/ERR (1) Ferroptosis (1) Guanylate Cyclase (1) IFNAR (1) iGluR (7) Isotope-Labeled Compounds (4) MDM-2/p53 (1) MOFs (1) NADPH Oxidase (1) PDI (1) PKC (1) Reactive Oxygen Species (ROS) (7) Reference Standards (2) Serotonin Transporter (1) Sirtuin (1)
By Research Areas:	Cancer (10) Cardiovascular Disease (8) Endocrinology (2) Inflammation/Immunology (12) Metabolic Disease (3) Neurological Disease (29)

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Targets Recommended: NO Synthase PGE synthase Acetolactate Synthase (ALS) Thymidylate Synthase Cellulose Synthase ATP Synthase GSK-3 Fatty Acid Synthase (FASN) Glucosylceramide Synthase (GCS) Cyclic GMP-AMP Synthase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100807

Quinolinic acid Maximum Cited Publications 7 Publications Verification	MOFs iGluR Endogenous Metabolite Reactive Oxygen Species (ROS) NO Synthase Apoptosis	Neurological Disease Inflammation/Immunology
Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates **nitric oxide synthase*, produces excessive NO, leading to calcium ion influx and neuronal* apoptosis .

HY-18731

1400W Dihydrochloride Maximum Cited Publications 28 Publications Verification	NO Synthase Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
1400W dihydrochloride is the dihydrochloride form of 1400W (HY-18730). 1400W is a slow, tight binding, and highly selective inducible nitric-oxide synthase (iNOS) inhibitor, with a K_d value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving the spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation .

HY-100986

L-NIO dihydrochloride 1 Publications Verification	NO Synthase	Cardiovascular Disease
L-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with K_is of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively . L-NIO dihydrochloride induces a consistentfocal ischemic infarctin rats .

HY-100807S

Quinolinic acid-d3 2 Publications Verification	Isotope-Labeled Compounds iGluR Endogenous Metabolite Reactive Oxygen Species (ROS) NO Synthase Apoptosis	Neurological Disease Inflammation/Immunology
Quinolinic acid-d₃ is the deuterium labeled Quinolinic acid. Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates **nitric oxide synthase*, produces excessive NO, leading to calcium ion influx and neuronal* apoptosis.

HY-148417

ZZL-7	Serotonin Transporter	Neurological Disease
ZZL-7 is a fast-onset antidepressant agent. ZZL-7 works by disrupting the interaction between the serotonin transporter (SERT) and neuronal nitric oxide synthase (nNOS) in the dorsal raphe nucleus (DRN). ZZL-7 can cross the blood-brain barrier readily. ZZL-7 can be used for the research of major depressive disorder (MDD) .

HY-18730

1400W Maximum Cited Publications 28 Publications Verification W1400	NO Synthase Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
1400W is a slow, tight binding, and highly selective inducible nitric-oxide synthase (iNOS) inhibitor, with a K_d value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving the spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation .

HY-12119

GW274150 2 Publications Verification	NO Synthase	Neurological Disease Inflammation/Immunology
GW274150 is a potent, selective, orally active and NADPH-dependent inhibitor of human *inducible nitric* oxide synthase (iNOS) (IC₅₀=2.19 μM; K_d=40 nM) and rat iNOS (ED₅₀=1.15 μM). GW274150 also displays less potency for both humans or rats endothelial NOS (eNOS*) and neuronal* NOS (nNOS). GW274150 exerts a protective role in an acute model of lung injury inflammation .

HY-P0117

Tat-NR2B9c 5+ Cited Publications Tat-NR2Bct; NA-1	iGluR NO Synthase	Neurological Disease
Tat-NR2B9c (Tat-NR2Bct; NA-1) is a postsynaptic density-95 (PSD-95) inhibitor, with EC₅₀ values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c disrupts the PSD-95/NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC₅₀ values of 0.5 μM and 8 μM, respectively. Tat-NR2B9c also inhibits neuronal nitric oxide synthase (nNOS)/PSD-95 interaction, and possesses neuroprotective efficacy .

HY-100807R

Quinolinic acid (Standard) Maximum Cited Publications 7 Publications Verification	Reference Standards iGluR Endogenous Metabolite Reactive Oxygen Species (ROS) NO Synthase Apoptosis	Neurological Disease Inflammation/Immunology
Quinolinic acid (Standard) is the analytical standard of Quinolinic acid. This product is intended for research and analytical applications. Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates **nitric oxide synthase*, produces excessive NO, leading to calcium ion influx and neuronal* apoptosis.

HY-B0503

2-Thiouracil 2 Publications Verification Thiouracil	NO Synthase	Endocrinology Cancer
2-Thiouracil (Thiouracil) is a selective neuronal nitric oxide synthase (nNOS) inhibitor with a K_i value of 20 μM. 2-Thiouracil antagonizes BH4-induced nNOS dimerization. 2-Thiouracil is also an antithyroid compound and a highly specific melanoma detector. 2-Thiouracil stimulates the growth of pea and corn root segments .

HY-118700

2-Iminobiotin Guanidinobiotin	NO Synthase	Neurological Disease
2-Iminobiotin (Guanidinobiotin) is a biotin (vitamin H or B7) analog. 2-Iminobiotin is a reversible **nitric oxide synthases inhibitor with K_is of 21.8 and 37.5μM for murine iNOS and rat n-cNOS*, respectively . 2-Iminobiotin superimposes on hypothermia protects human neuronal* cells from hypoxia-induced cell damage .

HY-12379

NS-2028 1 Publications Verification	Guanylate Cyclase	Inflammation/Immunology
NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor with IC₅₀ values of 30 nM and 200 nM for basal and NO-stimulated enzyme activity . NS-2028 inhibits soluble Guanylyl Cyclase activity in homogenates of mouse cerebellum and neuronal NO synthase with IC₅₀ values of 17 nM and 20 nM . NS-2028 inhibits 3-morpholino-sydnonimine (SIN-1)-elicited formation of cyclic GMP in human cultured umbilical vein endothelial cells with an IC₅₀ of 30 nM . NS-2028 is commonly used in the research of nitric oxide signaling pathways, it inhibits NO-dependent relaxant responses in non-vascular smooth muscle completely (1 μM) . NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability .

HY-12119A

GW274150 phosphate 2 Publications Verification	NO Synthase	Neurological Disease Inflammation/Immunology
GW274150 phosphate is a potent, selective, orally active and NADPH-dependent inhibitor of human *inducible nitric* oxide synthase (iNOS) (IC₅₀=2.19 μM; K_d=40 nM) and rat iNOS (ED₅₀=1.15 μM). GW274150 phosphate displays less potency for both humans or rats endothelial NOS (eNOS*) and neuronal* NOS (nNOS). GW274150 phosphate exerts a protective role in an acute model of lung injury inflammation .

HY-102062A

Nω-Propyl-L-arginine hydrochloride 1 Publications Verification N-omega-Propyl-L-arginine hydrochloride	NO Synthase	Neurological Disease
Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) hydrochloride is a potent, competitive, and highly selective inhibitor of neuronal nitric oxide synthase (nNOS), with a K_i of 57 nM. Nω-Propyl-L-arginine hydrochloride displays a 149-fold selectivity for nNOS over endothelial NOS (eNOS) .

HY-102062

Nω-Propyl-L-arginine 1 Publications Verification N-omega-Propyl-L-arginine	NO Synthase	Neurological Disease
Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) is a potent, competitive, and highly selective inhibitor of neuronal nitric oxide synthase (nNOS), with a K_i of 57 nM. Nω-Propyl-L-arginine displays a 149-fold selectivity for nNOS over endothelial NOS (eNOS) .

HY-100807S2

Quinolinic acid-13C4,15N	Isotope-Labeled Compounds iGluR Endogenous Metabolite Reactive Oxygen Species (ROS) NO Synthase Apoptosis	Neurological Disease Inflammation/Immunology
Quinolinic acid-13C4, 15N is an isotopic labeled Quinolinic acid (HY-100807). Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates **nitric oxide synthase*, produces excessive NO, leading to calcium ion influx and neuronal* apoptosis.

HY-101175

3-Bromo-7-nitroindazole 1 Publications Verification	NO Synthase	Neurological Disease Metabolic Disease
3-Bromo-7-nitroindazole is a potent and selective inhibitor of neuronal nitric oxide synthase (nNOS). 3-Bromo-7-nitroindazole affects the intercellular messenger nitric oxide (NO) synthesis throughout the body and brain. 3-Bromo-7-nitroindazole can be used for the researches of metabolic and neurological disease, such as diabetes, stroke and depression .

HY-135224

1,4-PBIT dihydrobromide 1,4-PB-ITU dihydrobromide	NO Synthase	Cancer
1,4-PBIT (1,4-PB-ITU) dihydrobromide (compound 46) is a potent nitric oxide synthases (NOS) inhibitor, with K_i values of 7.6 nM, 360 nM, and 16 nM for the inducible (iNOS), endothelial (eNOS), and neuronal (nNOS) isozymes, respectively .

HY-118700A

2-Iminobiotin hydrobromide Guanidinobiotin hydrobromide	NO Synthase	Neurological Disease
2-Iminobiotin hydrobromide (Guanidinobiotin hydrobromide) is a biotin (vitamin H or B7) analog. 2-Iminobiotin hydrobromide is a reversible **nitric oxide synthases inhibitor with K_is of 21.8 and 37.5 μM for murine iNOS and rat n-cNOS*, respectively . 2-Iminobiotin hydrobromide superimposes on hypothermia protects human neuronal* cells from hypoxia-induced cell damage .

HY-P0117A

Tat-NR2B9c TFA 5+ Cited Publications Tat-NR2Bct TFA; NA-1 TFA	iGluR NO Synthase	Neurological Disease
Tat-NR2B9c TFA (Tat-NR2Bct TFA) is a postsynaptic density-95 (PSD-95) inhibitor, with EC₅₀ values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c TFA disrupts the PSD-95/NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC₅₀ values of 0.5 μM and 8 μM, respectively. Tat-NR2B9c TFA also inhibits neuronal nitric oxide synthase (nNOS)/PSD-95 interaction, and possesses neuroprotective efficacy .

HY-W009300

4-Hydroxyestrone 1 Publications Verification 4-OHE1	Endogenous Metabolite Estrogen Receptor/ERR Sirtuin MDM-2/p53 PDI Ferroptosis Reactive Oxygen Species (ROS)	Neurological Disease Metabolic Disease Cancer
4-Hydroxyestrone (4-OHE1) is a brain-penetrant estrogen metabolite. 4-Hydroxyestrone shows neuroprotective effects involving increased cytoplasmic localization of p53 resulting from SIRT1-mediated p53 deacetylation. 4-Hydroxyestrone relies on PDI to mediate its protective effect against chemically induced ferroptosis in estrogen receptor-negative cancer cells. 4-Hydroxyestrone inhibits lipid peroxidation and lipid-ROS accumulation. 4-Hydroxyestrone blocks preovulatory luteinizing hormone surges in Rattus norvegicus. 4-Hydroxyestrone can be used for the researches of neurodegeneration, breast cancer and endocrine disease .

HY-100986B

L-NIO	NO Synthase	Cardiovascular Disease
L-NIO is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with K_is of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively . L-NIO induces a consistentfocal ischemic infarctin rats .

HY-100807S1

Quinolinic acid-13C7	Isotope-Labeled Compounds iGluR Endogenous Metabolite Reactive Oxygen Species (ROS) NO Synthase Apoptosis	Neurological Disease
Quinolinic acid- ¹³C₇ is the ¹³C labeled Quinolinic acid (HY-100807). Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates **nitric oxide synthase*, produces excessive NO, leading to calcium ion influx and neuronal* apoptosis.

HY-130579

Vinyl-L-NIO hydrochloride L-VNIO hydrochloride	NO Synthase NADPH Oxidase	Cardiovascular Disease Neurological Disease
Vinyl-L-NIO (L-VNIO) hydrochloride is a neuronal **nitric oxide synthase (NOS) inhibitor with a rat K_i of 0.10 μM. Vinyl-L-NIO hydrochloride inhibits NADPH** oxidase activity, attenuates renal fibrosis, inflammation, oxidative stress indices, and albuminuria. Vinyl-L-NIO hydrochloride can be used for the research of parkinson's disease, migraine headache, and hypertension .

HY-122060

BYK 191023	NO Synthase	Metabolic Disease
BYK 191023 is a selective and L-arginine competitive inducible nitric-oxide synthase inhibitor with an IC₅₀ value of 86 nM, 17 µM, 162 µM for inducible (iNOS), neuronal (nNOS), and endothelial (eNOS) NO synthases respectively .

HY-149339

hnNOS-IN-2	NO Synthase	Neurological Disease
hnNOS-IN-2 (compound 17) is a human neuronal nitric oxide synthase (hnNOS) inhibitor with good metabolic stability. hnNOS-IN-2 can be used for research in neurodegenerative diseases .

HY-U00432B

S-MTC acetate S-Methyl-L-thiocitrulline acetate	NO Synthase Endogenous Metabolite	Inflammation/Immunology
S-MTC acetate (S-Methyl-L-thiocitrulline acetate) acts as a powerful inhibitor of inducible nitric oxide synthase, favoring the inhibition of constitutive (neuronal) nitric oxide synthase over inducible (endothelial) nitric oxide synthase.

HY-P0184

Camstatin	NO Synthase	Neurological Disease
Camstatin, a functionally active 25-residue fragment of PEP-19's IQ motif, binds calmodulin and inhibits neuronal **nitric oxide (NO) synthase** .

HY-P0184A

Camstatin TFA	NO Synthase	Neurological Disease
Camstatin TFA, a functionally active 25-residue fragment of PEP-19's IQ motif, binds calmodulin and inhibits neuronal **nitric oxide (NO) synthase** .

HY-117786

Go 7874	PKC	Neurological Disease
Go 7874 is a protein kinase C (PKC) inhibitor. Go 7874 mediated neuroprotection against LPS/IFNg-induced neuronal cell death in an immune-mediated neurotoxicity model, not through PKC activity. In contrast, the neuroprotective mechanism of Go 7874 involves inhibition of inducible nitric oxide synthase (iNOS) gene expression, followed by reduced nitric oxide (NO) production .

HY-182519

HMN-1180	NO Synthase	Neurological Disease
HMN-1180 is a selective, competitive neuronal nitric oxide synthase (nNOS) inhibitor with a K_i value of 5.4 μM against rat nNOS. HMN-1180 exerts no significant effect on endothelial nitric oxide synthase (eNOS) or inducible nitric oxide synthase (iNOS). HMN-1180 inhibits nitric oxide production. HMN-1180 can be used for the study of nNOS-related neuronal functional physiology .

HY-B0503S

2-Thiouracil-13C,15N2 Thiouracil-¹³C,¹⁵N₂	Isotope-Labeled Compounds NO Synthase	Endocrinology Cancer
2-Thiouracil- ¹³C, ¹⁵N₂ is the ¹³C, ¹⁵N labeled 2-Thiouracil. 2-Thiouracil (Thiouracil) is an antithyroid compound. 2-Thiouracil can function as a highly specific melanoma seeker. 2-Thiouracil is a selective inhibitor of neuronal nitric oxide synthase (nNOS) with a Ki of 20 μM.

HY-18731R

1400W Dihydrochloride (Standard)	NO Synthase Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
1400W (Dihydrochloride) (Standard) is the analytical standard of 1400W (Dihydrochloride). This product is intended for research and analytical applications. 1400W dihydrochloride is the dihydrochloride form of 1400W (HY-18730). 1400W is a slow, tight binding, and highly selective inducible nitric-oxide synthase (iNOS) inhibitor, with a Kd value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving the spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation .

HY-12119B

GW274150 dihydrochloride	NO Synthase	Neurological Disease Inflammation/Immunology
GW274150 (dihydrochloride) is a potent, selective, orally active and NADPH-dependent inhibitor of human *inducible nitric* oxide synthase (iNOS) (IC₅₀=2.19 μM; K_d=40 nM) and rat iNOS (ED₅₀=1.15 μM). GW274150 (dihydrochloride) displays less potency for both humans or rats endothelial NOS (eNOS*) and neuronal* NOS (nNOS). GW274150 (dihydrochloride) exerts a protective role in an acute model of lung injury inflammation .

HY-181642

nNOS-IN-3	NO Synthase	Neurological Disease Cancer
nNOS-IN-3 (compound 4) is an orally active, selective, neuronal nitric oxide synthase (nNOS) inhibitor with a human hnNOS K_i of 25 nM, rat rnNOS K_i of 18 nM, human heNOS K_i of 58140 nM, human hiNOS K_i of 6422 nM. nNOS-IN-3 binds to nNOS active sites via hydrogen bonds with Glu and chalcogen bonds with Met, fails to form chalcogen bonds with heNOS, and undergoes passive transcellular transport with minimal efflux liability. nNOS-IN-3 can be used for the research of neurodegenerative diseases and melanoma .

HY-W839206

NOS-IN-4	NO Synthase	Neurological Disease
NOS-IN-4 (Compound 3) is a neuronal nitric oxide synthase (nNOS) inhibitor with an IC₅₀ of 4.00 μM that inhibits nNOS activity. The combined use of alpha-lipoic acid and NOS-IN-4 has a protective effect against MPTP (HY-W114750)-induced dopamine depletion in the mouse brain. NOS-IN-4 can be used for the research of neurological disease .

HY-183944

BN80933	NO Synthase Reactive Oxygen Species (ROS)	Cardiovascular Disease Neurological Disease
BN80933 is a selective **neuronal nitric oxide synthase (nNOS) inhibitor with a rat K_i** of 0.92 μM. BN80933 inhibits lipid peroxidation, and blocks hypoxia-induced lactate dehydrogenase elevation and delayed 8-epiprostaglandin F₂α elevation. BN80933 can be used for the research of stroke, and traumatic brain injury .

HY-181711

nNOS-IN-6	NO Synthase	Neurological Disease Cancer
nNOS-IN-6 is a human neuronal nitric oxide synthase (hnNOS) inhibitor with a human hnNOS K_i of 16 nM, ~1800-fold selectivity over human eNOS, ~2900-fold selectivity over human iNOS, and a rat nNOS K_i of 34 nM.nNOS-IN-6 exhibits high effective permeability in PAMPA-BBB assays, crosses the blood-brain barrier, and shows sustained systemic exposure, low clearance, and robust brain penetration in mouse in vivo pharmacokinetic studies.nNOS-IN-6 can be used for the research of neurodegenerative diseases, melanoma .

HY-180828

iNOs-IN-8	NO Synthase	Cardiovascular Disease Neurological Disease
iNOs-IN-8 (Compound 13h) is an efficient and highly selective inducible nitric oxide synthase (iNOS) inhibitor, with an IC₅₀ of 238 nM. iNOs-IN-8 exhibits significant neuroprotective effects in oxygen-glucose deprivation/reoxygenation (OGD/R) and hydrogen peroxide-induced neuronal and endothelial cell damage. iNOs-IN-8 significantly reduces the volume of cerebral infarction and improves neurological function in rat models. iNOs-IN-8 can be used for the study of ischemic stroke .

HY-102062R

Nω-Propyl-L-arginine (Standard) N-omega-Propyl-L-arginine (Standard)	Reference Standards NO Synthase	Neurological Disease
Nω-Propyl-L-arginine (Standard) is the analytical standard of Nω-Propyl-L-arginine (HY-102062). This product is intended for research and analytical applications. Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) is a potent, competitive, and highly selective inhibitor of neuronal nitric oxide synthase (nNOS), with a K_i of 57 nM. Nω-Propyl-L-arginine displays a 149-fold selectivity for nNOS over endothelial NOS (eNOS) .

HY-181545A

nNOS-IN-2 trihydrochloride	NO Synthase IFNAR	Cancer
nNOS-IN-2 trihydrochloride is a blood-brain barrier-permeable nitric oxide synthase (nNOS) inhibitor. nNOS-IN-2 trihydrochloride exhibits Ki values of 1.7 nM and 2.3 nM against human and rat nNOS, respectively, and shows high selectivity for human eNOS and iNOS. nNOS-IN-2 trihydrochloride also effectively reduces PD-L1 expression in human melanoma cells under both basal conditions and IFN-γ exposure. nNOS-IN-2 trihydrochloride can be used for the study of melanoma and related signaling pathways .

Cat. No.	Product Name	Target	Research Area

HY-P0117

Tat-NR2B9c 5+ Cited Publications Tat-NR2Bct; NA-1	iGluR NO Synthase	Neurological Disease
Tat-NR2B9c (Tat-NR2Bct; NA-1) is a postsynaptic density-95 (PSD-95) inhibitor, with EC₅₀ values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c disrupts the PSD-95/NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC₅₀ values of 0.5 μM and 8 μM, respectively. Tat-NR2B9c also inhibits neuronal nitric oxide synthase (nNOS)/PSD-95 interaction, and possesses neuroprotective efficacy .

HY-P0117A

Tat-NR2B9c TFA 5+ Cited Publications Tat-NR2Bct TFA; NA-1 TFA	iGluR NO Synthase	Neurological Disease
Tat-NR2B9c TFA (Tat-NR2Bct TFA) is a postsynaptic density-95 (PSD-95) inhibitor, with EC₅₀ values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c TFA disrupts the PSD-95/NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC₅₀ values of 0.5 μM and 8 μM, respectively. Tat-NR2B9c TFA also inhibits neuronal nitric oxide synthase (nNOS)/PSD-95 interaction, and possesses neuroprotective efficacy .

HY-P0184

Camstatin	NO Synthase	Neurological Disease
Camstatin, a functionally active 25-residue fragment of PEP-19's IQ motif, binds calmodulin and inhibits neuronal **nitric oxide (NO) synthase** .

HY-P0184A

Camstatin TFA	NO Synthase	Neurological Disease
Camstatin TFA, a functionally active 25-residue fragment of PEP-19's IQ motif, binds calmodulin and inhibits neuronal **nitric oxide (NO) synthase** .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-100807

Quinolinic acid Maximum Cited Publications 7 Publications Verification	Alkaloids Structural Classification Microorganisms Disease markers Pyridine Alkaloids Nervous System Disorder Endogenous metabolite	MOFs iGluR Endogenous Metabolite Reactive Oxygen Species (ROS) NO Synthase Apoptosis
Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates **nitric oxide synthase*, produces excessive NO, leading to calcium ion influx and neuronal* apoptosis .

HY-100807R

Quinolinic acid (Standard) Maximum Cited Publications 7 Publications Verification	Structural Classification Alkaloids Microorganisms Ketones, Aldehydes, Acids Disease markers Pyridine Alkaloids Nervous System Disorder Endogenous metabolite Source Classification	Reference Standards iGluR Endogenous Metabolite Reactive Oxygen Species (ROS) NO Synthase Apoptosis
Quinolinic acid (Standard) is the analytical standard of Quinolinic acid. This product is intended for research and analytical applications. Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates **nitric oxide synthase*, produces excessive NO, leading to calcium ion influx and neuronal* apoptosis.

HY-W009300

4-Hydroxyestrone 1 Publications Verification 4-OHE1	Structural Classification Animals Neurological Disease Classification of Application Fields Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite Estrogen Receptor/ERR Sirtuin MDM-2/p53 PDI Ferroptosis Reactive Oxygen Species (ROS)
4-Hydroxyestrone (4-OHE1) is a brain-penetrant estrogen metabolite. 4-Hydroxyestrone shows neuroprotective effects involving increased cytoplasmic localization of p53 resulting from SIRT1-mediated p53 deacetylation. 4-Hydroxyestrone relies on PDI to mediate its protective effect against chemically induced ferroptosis in estrogen receptor-negative cancer cells. 4-Hydroxyestrone inhibits lipid peroxidation and lipid-ROS accumulation. 4-Hydroxyestrone blocks preovulatory luteinizing hormone surges in Rattus norvegicus. 4-Hydroxyestrone can be used for the researches of neurodegeneration, breast cancer and endocrine disease .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P70048

	PIN/DYNLL1 Protein, Human (His) rHuDynein light chain 1, cytoplasmic/DYNLL1, His; Dynein Light Chain 1 Cytoplasmic; 8 kDa Dynein Light Chain; DLC8; Dynein Light Chain LC8-Type 1; Protein Inhibitor of neuronal nitric oxide synthase; PIN; DYNLL1; DLC1; DNCL1; DNCLC1; HDLC1	Human	E. coli
	PIN/DYNLL1 acts as a non-catalytic accessory component in the cytoplasmic dynein 1 complex, connecting dynein to cargos and adapter proteins for dynein modulation. It functions as a motor for retrograde vesicle movement along microtubules, potentially influencing cytoskeletal structure. PIN/DYNLL1 enhances ESR1 transactivation and aids ESR1 nuclear localization. PIN/DYNLL1 Protein, Human (His) is the recombinant human-derived PIN/DYNLL1 protein, expressed by E. coli , with N-6*His labeled tag.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Chemical Structure

HY-100807S

Quinolinic acid-d3 2 Publications Verification
Quinolinic acid-d₃ is the deuterium labeled Quinolinic acid. Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates **nitric oxide synthase*, produces excessive NO, leading to calcium ion influx and neuronal* apoptosis.

HY-100807S2

Quinolinic acid-13C4,15N

Quinolinic acid-13C4, 15N is an isotopic labeled Quinolinic acid (HY-100807). Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis.

HY-100807S1

Quinolinic acid-13C7

Quinolinic acid- ¹³C₇ is the ¹³C labeled Quinolinic acid (HY-100807). Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis.

HY-B0503S

2-Thiouracil-13C,15N2
2-Thiouracil- ¹³C, ¹⁵N₂ is the ¹³C, ¹⁵N labeled 2-Thiouracil. 2-Thiouracil (Thiouracil) is an antithyroid compound. 2-Thiouracil can function as a highly specific melanoma seeker. 2-Thiouracil is a selective inhibitor of neuronal nitric oxide synthase (nNOS) with a Ki of 20 μM.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks