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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
616 Results for "
platelets aggregation
" in MedChemExpress (MCE) Product Catalog:
Products (616)
616 Results for "platelets aggregation" in MCE Product Catalog:
32
32 Publications Verification
Art. -Nr.: HY-17459
CAS. Nr.: 120202-66-6
Synonyms: (S)-(+)-Clopidogrel bisulfate; (S)-(+)-Clopidogrel hydrogen sulfate
Target:
Forschungsgebiete:
Clopidogrel hydrogen sulfate is an antiplatelet agent to prevent blood clots. Clopidogrel hydrogen sulfate inhibits CYP2B6 and CYP2C19 with IC50s of 18.2 nM and 524 nM, respectively . Clopidogrel hydrogen sulfate is a potent antithrombotic agent that inhibits ADP-induced platelet aggregation ．Clopidogrel hydrogen sulfate also is an orally active P2Y(12) inhibitor .
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Tolvaptan is a selective, competitive and orally active vasopressin receptor 2 (V2R) antagonist with an IC50 of 1.28 μM for the inhibition of arginine vasopressin (AVP)-induced platelet aggregation. Tolvaptan induces cell apoposis and affects cell cycle. Tolvaptan can be used for the research of hyponatremia .
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18 Cited Publications
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16 Cited Publications
Synonyms: 9,11-Methanoepoxy PGH2
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Forschungsgebiete:
U-46619 (9,11-Methanoepoxy PGH2) is a stable analogue of Thromboxane A2 (HY-113350) (TXA2) and acts as a potent TXA2 (TP) agonist. U-46619 also is a RhoA agonist. U-46619 stimulates the activation of RhoA through TXA2 receptor activation .
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15 Cited Publications
Art. -Nr.: HY-N0720
CAS. Nr.: 41060-15-5
Category:
Flavonoids Leguminosae Phenols Polyphenols Psoralea corylifolia L. Plants Disease Research Fields Cancer Isoflavones
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12 Cited Publications
Synonyms: AZD6140; AR-C 126532XX
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Forschungsgebiete:
Ticagrelor (AZD6140) is a reversible oral P2Y12 receptor antagonist for the treatment of platelet aggregation.
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12 Cited Publications
Synonyms: SCH 530348
Forschungsgebiete:
Vorapaxar (SCH 530348), an antiplatelet agent, is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist (Ki=8.1 nM). Vorapaxar (SCH 530348) inhibits thrombin receptor-activating peptide (TRAP)-induced platelet aggregation in a dose-dependent manner .
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12 Cited Publications
Synonyms: SCH 530348 sulfate
Forschungsgebiete:
Vorapaxar sulfate (SCH 530348 sulfate), an antiplatelet agent, is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist (Ki=8.1 nM). Vorapaxar sulfate inhibits thrombin receptor-activating peptide (TRAP)-induced platelet aggregation in a dose-dependent manner .
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10 Cited Publications
Art. -Nr.: HY-N0570
CAS. Nr.: 10597-60-1
Synonyms: DOPET; 3,4-Dihydroxyphenethyl alcohol; 3-Hydroxytyrosol
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9 Cited Publications
Art. -Nr.: HY-D0199
CAS. Nr.: 16178-48-6
Synonyms: Adenosine diphosphate disodium; ADP disodium
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9
9 Cited Publications
Art. -Nr.: HY-W010791
CAS. Nr.: 20398-34-9
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Forschungsgebiete:
Adenosine 5'-diphosphate sodium salt is a nucleoside diphosphate and the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate sodium salt induces human platelet aggregation and inhibits stimulated adenylate cyclase through its action on P2T-purinergic receptors .
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9 Cited Publications
Art. -Nr.: HY-114164H
CAS. Nr.: 9002-04-4
Synonyms: EC 3.4.21.5 (Lyophilized); Human Alpha Thrombin (Lyophilized)
Forschungsgebiete:
Human α-Thrombin (EC 3.4.21.5; Human Alpha Thrombin) (Lyophilized) is a terminal serine protease in the coagulation cascade, as well as a potent physiological platelet agonist and fibrin-generating enzyme in vivo. Human α-Thrombin catalyzes the conversion of fibrinogen to fibrin for blood clot formation, and activates platelet aggregation by cleaving the protease-activated receptors PAR1 (major) (Kd = 1 nM) and PAR4 (minor) on the platelet surface to expose tethered ligands. Human α-Thrombin also amplifies coagulation via positive feedback by activating coagulation factors V, VIII, XI (FV/FVIII/FXI), and switches to activate protein C to exert anticoagulant effects after binding to thrombomodulin .
This product is in a freeze-dried form.
This product is in a freeze-dried form.
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Forschungsgebiete:
S-Nitroso-N-acetyl-DL-penicillamine (SNAP) is a nitric oxide donor and acts as a stable inhibitor of platelet aggregation .
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7 Cited Publications
Synonyms: C48/80 trihydrochloride
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Forschungsgebiete:
Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of condensation products of N-methyl-p-methoxyphenethylamine with formaldehyde. Compound 48/80 trihydrochloride is also a histamine releaser and a mast cell degranulator. Compound 48/80 inhibits phosphatidylinositol-specific phospholipase C activity from human platelets .
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7 Cited Publications
Synonyms: BIBR 953; BIBR 953ZW
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Forschungsgebiete:
Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM) .
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7 Cited Publications
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Forschungsgebiete:
NF449 octasodium is a highly potent P2X1 receptor antagonist, with IC50s of 0.28, 0.69, and 120 nM for rP2X1, rP2X1+5, P2X2+3, respectively. NF449 octasodium is a Gsα-selective G Protein antagonist. NF449 octasodium suppresses the rate of GTP[γS] binding to Gsα-s, inhibits the stimulation of adenylyl cyclase activity, and blocks the coupling of β-adrenergic receptors to Gs .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
