Oligomycin
Based on 121 publication(s) in Google Scholar
Oligomycin, an antifungal antibiotic, is an inhibitor of H+-ATP-synthase. Oligomycin blocks oxidative phosphorylation and the electron transport chain. Oligomycin inhibits HIF-1alpha expression in hypoxic tumor cells.
For research use only. We do not sell to patients.
- Purity : 98.64%
- CAS No.: 1404-19-9
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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HY-B1756
RotenoneMitochondrial Complex I Inhibitor -
HY-100410
FCCPOXPHOS Uncoupler -
HY-13966
2-Deoxy-D-glucoseGlycolysis Inhibitor -
HY-16589
Oligomycin AMitochondrial ATP Synthase Inhibitor -
HY-16592
Brefeldin AProtein Transport Inhibitor -
HY-100558
Bafilomycin A1V-ATPase Inhibitor -
HY-13433
ThapsigarginER Stress Inducer -
HY-B0389
D-GlucoseMonosaccharide -
HY-100941
CCCPOXPHOS Uncoupler -
HY-50202
EtomoxirCPT1a Inhibitor -
HY-10219
RapamycinmTOR Inhibitor -
HY-15877
BTB06584F1Fo-ATPsynthase Inhibitor
Publications Citing Use of MedChemExpress (MCE) Oligomycin
More- Cell. 2024 Apr 25;187(9):2269-2287.e16. [Abstract]
- Cell Metab. 2026 Aug 4;38(8):1702-1721.e11.
- Cell Metab. 2026 Jun 24:S1550-4131(26)00226-3. [Abstract]
- Cell Metab. 2026 May 5;38(5):963-980.e12. [Abstract]
- Nat Metab. 2026 Jan;8(1):177-195. [Abstract]
- Nat Immunol. 2024 Jun;25(6):981-993. [Abstract]
- Cell Mol Immunol. 2026 May;23(5):491-504. [Abstract]
- Cell Mol Immunol. 2024 Jun;21(6):546-560. [Abstract]
- Cell Stem Cell. 2025 Apr 3;32(4):547-563.e7. [Abstract]
- Nat Cell Biol. 2026 May 27. [Abstract]
- Nat Cell Biol. 2026 Apr;28(4):707-724. [Abstract]
- Cancer Res. 2023 Dec 15;83(24):4063-4079. [Abstract]
- Nat Microbiol. 2025 Oct;10(10):2521-2536. [Abstract]
- Autophagy. 2026 Jul 31:1-19.
- Autophagy. 2025 Dec 26:1-18. [Abstract]
- Autophagy. 2025 Mar;21(3):548-564. [Abstract]
- Autophagy. 2024 Nov;20(11):2556-2570. [Abstract]
- Nat Commun. 2026 Jan 31;17(1):2227. [Abstract]
- Nat Commun. 2024 Oct 8;15(1):8723. [Abstract]
- Nat Commun. 2022 Jun 17;13(1):3486. [Abstract]
- Exp Mol Med. 2022 Nov;54(11):2007-2021. [Abstract]
- J Adv Res. 2025 Jan 2:S2090-1232(24)00623-4. [Abstract]
- J Am Chem Soc. 2023 Oct 18;145(41):22433-22441. [Abstract]
- Redox Biol. 2026 Jun 22:95:104272. [Abstract]
- Redox Biol. 2024 Jul:73:103207. [Abstract]
- Redox Biol. 2021 Jul:43:101994. [Abstract]
- Mol Cell. 2022 May 19;82(10):1821-1835.e6. [Abstract]
- J Nanobiotechnology. 2025 Aug 12;23(1):562. [Abstract]
- J Exp Clin Cancer Res. 2025 Jan 3;44(1):3. [Abstract]
- Adv Sci (Weinh). 2025 Oct 13:e09383. [Abstract]
- Adv Sci (Weinh). 2025 May;12(20):e2413376. [Abstract]
- Biomaterials. 2025 Nov:322:123391. [Abstract]
- Cell Death Differ. 2025 Oct 7. [Abstract]
- Pharmacol Res. 2026 Jun:228:108203. [Abstract]
- Engineering. 2026 May 20.
- Cell Death Dis. 2026 Jan 8;17(1):11. [Abstract]
- Engineering. 2025 Nov 14.
- Cell Death Dis. 2025 Nov 7;16(1):805. [Abstract]
- Engineering. 2024 Sep 6.
- Cell Death Dis. 2024 Mar 29;15(3):236. [Abstract]
- Cell Death Dis. 2022 Oct 26;13(10):899. [Abstract]
- Cell Death Dis. 2021 Apr 20;12(5):413. [Abstract]
- Pharmacol Res. 2021 Feb:164:105367. [Abstract]
- Cancer Lett. 2026 May 24:218621. [Abstract]
- Cancer Lett. 2022 Dec 1:550:215918. [Abstract]
- Phytomedicine. 2026 Jan:150:157684. [Abstract]
- Phytomedicine. 2024 Jul:129:155675. [Abstract]
- EBioMedicine. 2025 Aug 15:119:105879. [Abstract]
- Appl Phys Rev. 2026 Jan 21.
- Acta Pharmacol Sin. 2026 Apr 8. [Abstract]
- Cell Death Discov. 2025 Jul 2;11(1):299. [Abstract]
- Acta Pharmacol Sin. 2025 Jun 11. [Abstract]
- Cell Death Discov. 2025 Mar 1;11(1):82. [Abstract]
- NPJ Precis Oncol. 2025 Jun 5;9(1):163. [Abstract]
- J Transl Med. 2024 Jun 5;22(1):535. [Abstract]
- J Transl Med. 2024 Jan 18;22(1):74. [Abstract]
- J Transl Med. 2023 Sep 7;21(1):605. [Abstract]
- J Transl Med. 2023 Aug 18;21(1):553. [Abstract]
- Proc Natl Acad Sci U S A. 2026 Mar 31;123(13):e2520119123. [Abstract]
- Dev Cell. 2025 Apr 18:S1534-5807(25)00206-0. [Abstract]
- Oncogene. 2024 Oct;43(44):3215-3226. [Abstract]
- Int J Mol Med. 2026 Jul;58(1):178. [Abstract]
- Sens Actuators B Chem. 2025 Jul 1.
- Free Radic Biol Med. 2025 Mar 1:229:399-414. [Abstract]
- Free Radic Biol Med. 2024 Oct:223:473-492. [Abstract]
- Free Radic Biol Med. 2023 Mar:198:83-91. [Abstract]
- EMBO Mol Med. 2025 Oct 13. [Abstract]
- Cancer Immunol Res. 2023 Apr 3;11(4):515-529. [Abstract]
- Clin Transl Med. 2022 Jan;12(1):e686. [Abstract]
- ACS Appl Mater Interfaces. 2025 Oct 1;17(39):54453-54465. [Abstract]
- Stem Cell Res Ther. 2025 May 4;16(1):225. [Abstract]
- Aging Cell. 2025 Oct;24(10):e70213. [Abstract]
- Cell Rep. 2025 Jul 30;44(8):116091. [Abstract]
- Cell Rep. 2023 Aug 28;42(9):113044. [Abstract]
- Cell Rep. 2023 Jun 6;42(6):112617. [Abstract]
- Front Immunol. 2022 Mar 10;13:771732. [Abstract]
- J Agric Food Chem. 2024 Jun 12;72(23):13039-13053. [Abstract]
- Ecotoxicol Environ Saf. 2023 Oct 1:264:115472. [Abstract]
- Cell Mol Life Sci. 2025 Apr 12;82(1):157. [Abstract]
- Life Sci. 2026 Apr 1:390:124256. [Abstract]
- EMBO Rep. 2023 Nov 6;24(11):e56958. [Abstract]
- Cancer Metab. 2026 Apr 2;14(1):13. [Abstract]
- Cancer Metab. 2025 Mar 31;13(1):16. [Abstract]
- Cancer Metab. 2022 Dec 6;10(1):22. [Abstract]
- Commun Biol. 2026 Apr 30;9(1):909. [Abstract]
- Mar Drugs. 2021 Jan 31;19(2):79. [Abstract]
- Int J Mol Sci. 2024 Sep 29;25(19):10514. [Abstract]
- Int Dent J. 2024 Dec;74(6):1386-1396. [Abstract]
- Virol Sin. 2025 Nov 21:S1995-820X(25)00161-0. [Abstract]
- iScience. 2026 Jun 22;29(7). [Abstract]
- iScience. 2022 Aug 4;25(9):104844. [Abstract]
- iScience. 2021 Sep 25;24(10):103170. [Abstract]
- J Biol Chem. 2026 May 27:113207. [Abstract]
- J Virol. 2025 Nov 25;99(11):e0157625. [Abstract]
- Expert Rev Clin Immunol. 2025 Aug;21(8):1171-1181. [Abstract]
- Biochim Biophys Acta Mol Cell Biol Lipids. 2025 May;1870(4):159610. [Abstract]
- Pathol Res Pract. 2026 Apr:280:156383. [Abstract]
- J Bioenerg Biomembr. 2026 Mar 18. [Abstract]
- Toxicol Appl Pharmacol. 2026 Jun:511:117776. [Abstract]
- Toxicol Appl Pharmacol. 2025 Dec:505:117578. [Abstract]
- Drug Metab Dispos. 2025 Nov;53(11):100172. [Abstract]
- Biochem Eng J. 2024 Nov.
- Toxicol Appl Pharmacol. 2024 May:486:116951. [Abstract]
- Int J Biochem Cell Biol. 2025 Oct:187:106831. [Abstract]
- Brain Res. 2025 Mar 1:1850:149424. [Abstract]
- Free Radic Res. 2024 May-Jun;58(6-7):417-429. [Abstract]
- Immunopharmacol Immunotoxicol. 2023 Jun;45(3):355-369. [Abstract]
- J Immunother. 2024 Oct 1;47(8):313-322. [Abstract]
- Toxicon. 2026 Jun 15:276:109067. [Abstract]
- Vet Microbiol. 2025 Oct:309:110695. [Abstract]
- Prostate. 2025 Oct 1. [Abstract]
- Prostate. 2025 Oct 1. [Abstract]
- Biochem Biophys Res Commun. 2023 Sep 3:671:46-57. [Abstract]
- bioRxiv. 2026 Jan 7.
- bioRxiv. 2025 Nov 4.
- SSRN. 2025 Nov 26.
- Pharmacological Research Modern Chinese Medicine. 2025 Sep 20;17:100693.
- bioRxiv. 2025 April 16.
- bioRxiv. 2024 June 27.
- bioRxiv. 2024 June 03.
- Oxid Med Cell Longev. 2022 Apr 5;2022:8192552. [Abstract]
Customer Validation & Images
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All Antibiotic Isoforms
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Biological Activity
Description
In Vitro
Chemical Information
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CAS No. 1404-19-9
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Appearance Solid
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Color White to off-white
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SMILES
O=C1/C=C/[C@H](C)[C@@H](O)[C@H](C)C([C@H](C)[C@@H](O)[C@H](C)C([C@@](O)(C)[C@@H](O)[C@H](C)C/C=C/C=C/[C@H](CC)CC[C@]2([H])O[C@@]3(O[C@@H](C[C@H](O)C)[C@@H](C)CC3)[C@H]([C@@](O1)([H])[C@@H]2C)C)=O)=O.O=C4/C=C/[C@H](C)[C@@H](O)[C@H](C)C([C@H](C)[C@@H](O)[C@H](C)C([C@@H](C)[C@@H](O)[C@H](C)C/C=C/C=C/[C@@](CC)([H])CC[C@]5([H])O[C@@]6(O[C@](C[C@H](O)C)([H])[C@@H](C)CC6)[C@H]([C@@](O4)([H])[C@@H]5C)C)=O)=O
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Structure Classification
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Initial Source
Streptomyces
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (121)
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Journal Impact Factor
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Most Recent
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Cell
2024 Apr 25;187(9):2269-2287.e16. PMID: 38608703
Oligomycin purchased from MedChemExpress. Usage Cited in: Cell. 2024 Apr 25;187(9):2269-2287.e16. [Abstract]
Abundance of BRCA2, γH2AX protein, and MG-H1 adduct formation in HeLa Kyoto cells after treatment with Oligomycin (1 μM) for 4, 24, and 48 h.
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Cell Metab
Gut microbiota-derived lysine phenylacetylation impairs mitochondrial function and is alleviated by SIRT3. [Abstract]2026 Jun 24:S1550-4131(26)00226-3. PMID: 42341761 -
Cell Metab
Psoriasis modulates inflammatory bowel disease risk and intestinal epithelium lipid metabolism via IL-1β-producing macrophages. [Abstract]2026 May 5;38(5):963-980.e12. PMID: 41856104 -
Nat Metab
IL-21 mediates crosstalk between T cells and NK cells during the remission of type 1 diabetes. [Abstract]2026 Jan;8(1):177-195. PMID: 41566069 -
Nat Immunol
An IFNγ-dependent immune-endocrine circuit lowers blood glucose to potentiate the innate antiviral immune response. [Abstract]2024 Jun;25(6):981-993. PMID: 38811816 -
Cell Mol Immunol
MAIT cell plasticity generates CD4+ MAIT cells that promote HCC progression via metabolic crosstalk with tumor cells. [Abstract]2026 May;23(5):491-504. PMID: 41974917 -
Cell Mol Immunol
Lkb1 orchestrates γδ T-cell metabolic and functional fitness to control IL-17-mediated autoimmune hepatitis. [Abstract]2024 Jun;21(6):546-560. PMID: 38641698 -
Cell Stem Cell
Enhanced viability and functional maturity of iPSC-derived islet organoids by collagen-VI-enriched ECM scaffolds. [Abstract]2025 Apr 3;32(4):547-563.e7. PMID: 39999846 -
Nat Cell Biol
2026 May 27. PMID: 42203926 -
Nat Cell Biol
An extracellular vesicle-mediated mitochondrial transfer network critical for testosterone synthesis. [Abstract]2026 Apr;28(4):707-724. PMID: 41760931 -
Cancer Res
Fructose-induced mTORC1 Activation Promotes Pancreatic Cancer Progression through Inhibition of Autophagy. [Abstract]2023 Dec 15;83(24):4063-4079. PMID: 37738413 -
Nat Microbiol
Oxaloacetate sensing promotes innate immune antiviral defence against influenza virus infection. [Abstract]2025 Oct;10(10):2521-2536. PMID: 40983701 -
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Autophagy
ATG9A-PLA2G6 axis reprograms phospholipid metabolism to drive metabolic liver disease and hepatocellular carcinoma. [Abstract]2025 Dec 26:1-18. PMID: 41358570 -
Autophagy
Copper aggravated synaptic damage after traumatic brain injury by downregulating BNIP3-mediated mitophagy. [Abstract]2025 Mar;21(3):548-564. PMID: 39415457 -
Autophagy
Signal-sustained imaging of mitophagy with an Enzyme-Activatable Metabolic Lipid-Labeling Probe. [Abstract]2024 Nov;20(11):2556-2570. PMID: 38873937 -
Nat Commun
Microbiota-induced EI24 improves homeostasis but impedes function of alveolar macrophages via metabolic regulation. [Abstract]2026 Jan 31;17(1):2227. PMID: 41620436 -
Nat Commun
A germline-to-soma signal triggers an age-related decline of mitochondrial stress response. [Abstract]2024 Oct 8;15(1):8723. PMID: 39379393
Oligomycin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Oct 8;15(1):8723. [Abstract]
qRT-PCR analysis of Chop and Asns mRNA levels in seven-month-old C57BL/6J male and female mice treated with DMSO or Oligomycin (0.5 mg/kg, ip).
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Nat Commun
2022 Jun 17;13(1):3486. PMID: 35710796 -
Exp Mol Med
Simultaneous treatment with sorafenib and glucose restriction inhibits hepatocellular carcinoma in vitro and in vivo by impairing SIAH1-mediated mitophagy. [Abstract]2022 Nov;54(11):2007-2021. PMID: 36385558 -
J Adv Res
Parkin modulates the hepatocellular carcinoma microenvironment by regulating PD-1/PD-L1 signalling. [Abstract]2025 Jan 2:S2090-1232(24)00623-4. PMID: 39755271
Oligomycin purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Jan 2:S2090-1232(24)00623-4. [Abstract]
Real-time analysis of the OCR was carried out with a Seahorse analyser with single cells from mice liver tissues following treatment with Oligomycin (1.5 μM).
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J Am Chem Soc
2023 Oct 18;145(41):22433-22441. PMID: 37812815
Oligomycin purchased from MedChemExpress. Usage Cited in: J Am Chem Soc. 2023 Oct 18;145(41):22433-22441. [Abstract]
Typical curves showing temperature fluctuations of individual cells at different time intervals in the absence of stimulus (black) and after the addition of Oligomycin (blue) (100 μM).
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Redox Biol
Mitochondrial OXPHOS integrates immunometabolic cascade for bone regeneration via coupled ATP production and ROS homeostasis. [Abstract]2026 Jun 22:95:104272. PMID: 42335846 -
Redox Biol
Redistribution of defective mitochondria-mediated dihydroorotate dehydrogenase imparts 5-fluorouracil resistance in colorectal cancer. [Abstract]2024 Jul:73:103207. PMID: 38805974 -
Redox Biol
Hypoxic acclimation improves cardiac redox homeostasis and protects heart against ischemia-reperfusion injury through upregulation of O-GlcNAcylation. [Abstract]2021 Jul:43:101994. PMID: 33964586 -
Mol Cell
Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis. [Abstract]2022 May 19;82(10):1821-1835.e6. PMID: 35381197 -
J Nanobiotechnology
Radiocleavable rare-earth nanoactivators targeting over-expressed folate receptors induce mitochondrial dysfunction and remodel immune suppressive microenvironment in pancreatic cancer. [Abstract]2025 Aug 12;23(1):562. PMID: 40797208 -
J Exp Clin Cancer Res
CYP3A5 promotes glioblastoma stemness and chemoresistance through fine-tuning NAD+/NADH ratio. [Abstract]2025 Jan 3;44(1):3. PMID: 39754188 -
Adv Sci (Weinh)
Faecalibaculum rodentium Alleviates Ionizing Radiation-Induced Damage in Mice by Improving Intestinal Integrity and Hematopoiesis via Its Metabolite Butyrate. [Abstract]2025 Oct 13:e09383. PMID: 41082369 -
Adv Sci (Weinh)
Massage-Mimicking Nanosheets Mechanically Reorganize Inter-organelle Contacts to Restore Mitochondrial Functions in Parkinson's Disease. [Abstract]2025 May;12(20):e2413376. PMID: 40223359
Oligomycin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 May;12(20):e2413376. [Abstract]
Fluorescence images of cellular ROS levels: NanoMassage ameliorate ROS generation and cell apoptosis induced by CCCP or Oligomycin (10 μM, 1 h) in neuron-like cells.
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Biomaterials
Radiation-triggerable bioreactors enable bioenergetic reprograming of cancer stem cell plasticity via targeted arginine metabolism disruption for augmented radio-immunotherapy. [Abstract]2025 Nov:322:123391. PMID: 40344881 -
Cell Death Differ
PDK4-driven lactate accumulation facilitates LPCAT2 lactylation to exacerbate sepsis-induced acute lung injury. [Abstract]2025 Oct 7. PMID: 41057687 -
Pharmacol Res
AXL prevents amyloid-β-induced microglial ferroptosis by sustaining SLC2A3-mediated mitochondrial respiration. [Abstract]2026 Jun:228:108203. PMID: 42025825 -
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Cell Death Dis
YBX1 orchestrates LDHA-mediated metabolic reprogramming and NF-κB activation to drive clear cell renal cell carcinoma progression. [Abstract]2026 Jan 8;17(1):11. PMID: 41507134 -
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Cell Death Dis
Impaired natural killer cell migration in HIV-infected individuals is caused by TIGIT-mediated inhibition of HIF-1α-dependent glycolysis. [Abstract]2025 Nov 7;16(1):805. PMID: 41203617 -
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Cell Death Dis
LncRNA SNHG26 promotes gastric cancer progression and metastasis by inducing c-Myc protein translation and an energy metabolism positive feedback loop. [Abstract]2024 Mar 29;15(3):236. PMID: 38553452 -
Cell Death Dis
The oncoprotein MUC1 facilitates breast cancer progression by promoting Pink1-dependent mitophagy via ATAD3A destabilization. [Abstract]2022 Oct 26;13(10):899. PMID: 36289190 -
Cell Death Dis
Mitochondrial quality control protects photoreceptors against oxidative stress in the H2O2-induced models of retinal degeneration diseases. [Abstract]2021 Apr 20;12(5):413. PMID: 33879768 -
Pharmacol Res
Novel selective hexokinase 2 inhibitor Benitrobenrazide blocks cancer cells growth by targeting glycolysis. [Abstract]2021 Feb:164:105367. PMID: 33307221 -
Cancer Lett
Repurposing the Neurokinin-1 receptor antagonist Aprepitant to eradicate relapsed/refractory acute lymphoblastic leukemia via mitochondria-driven necroptosis. [Abstract]2026 May 24:218621. PMID: 42184918 -
Cancer Lett
Obesity accelerates immune evasion of non-small cell lung carcinoma via TFEB-dependent upregulation of Siglec-15 and glycolytic reprogramming. [Abstract]2022 Dec 1:550:215918. PMID: 36150633 -
Phytomedicine
Notopterol attenuates synovitis via α7nAChR-dependent metabolic reprogramming of macrophage polarisation. [Abstract]2026 Jan:150:157684. PMID: 41442994 -
Phytomedicine
Ganoderic acid D attenuates gemcitabine resistance of triple-negative breast cancer cells by inhibiting glycolysis via HIF-1α destabilization. [Abstract]2024 Jul:129:155675. PMID: 38678954 -
EBioMedicine
Differential regulation of FADS2 by EZH2 reveals a metabolic vulnerability in ovarian cancer treatment. [Abstract]2025 Aug 15:119:105879. PMID: 40818202 -
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Acta Pharmacol Sin
Alkalization of the intracellular pH reprograms TNF-α signaling from inflammatory NF-κB activation to tumoricidal RIP kinase-dependent necroptosis in cancer cells. [Abstract]2026 Apr 8. PMID: 41951772 -
Cell Death Discov
DNMBP-AS1/hsa-miR-30a-5p/PGC1α axis suppresses tumor progression of colorectal cancer by inhibiting PKM2-mediated Warburg effect and enhance anti-PD-1 therapy efficacy. [Abstract]2025 Jul 2;11(1):299. PMID: 40603870 -
Acta Pharmacol Sin
YOD1 mediates isoproterenol-induced cardiac remodeling by deubiquitinating PKM2 and reducing PKM2 tetramerization in cardiomyocytes. [Abstract]2025 Jun 11. PMID: 40500343 -
Cell Death Discov
NDUFB7 mutations cause brain neuronal defects, lactic acidosis, and mitochondrial dysfunction in humans and zebrafish. [Abstract]2025 Mar 1;11(1):82. PMID: 40025060 -
NPJ Precis Oncol
TRIM65 regulates glucose metabolic reprogramming to promote glioma cell proliferation via ubiquitination and degradation of AMPK. [Abstract]2025 Jun 5;9(1):163. PMID: 40473847 -
J Transl Med
S1PR3 inhibition protects against LPS-induced ARDS by inhibiting NF-κB and improving mitochondrial oxidative phosphorylation. [Abstract]2024 Jun 5;22(1):535. PMID: 38840216 -
J Transl Med
Hypoxia-induced P4HA1 overexpression promotes post-ischemic angiogenesis by enhancing endothelial glycolysis through downregulating FBP1. [Abstract]2024 Jan 18;22(1):74. PMID: 38238754 -
J Transl Med
ESRRG-PKM2 axis reprograms metabolism to suppress esophageal squamous carcinoma progression and enhance anti-PD-1 therapy efficacy. [Abstract]2023 Sep 7;21(1):605. PMID: 37679788 -
J Transl Med
Rutaecarpine induces the differentiation of triple-negative breast cancer cells through inhibiting fumarate hydratase. [Abstract]2023 Aug 18;21(1):553. PMID: 37592347 -
Proc Natl Acad Sci U S A
Endogenous ATP-powered nanomotors directing neural stem cell differentiation for Parkinson's disease treatment. [Abstract]2026 Mar 31;123(13):e2520119123. PMID: 41880568 -
Dev Cell
2025 Apr 18:S1534-5807(25)00206-0. PMID: 40280135 -
Oncogene
The tumor suppressor Parkin exerts anticancer effects through regulating mitochondrial GAPDH activity. [Abstract]2024 Oct;43(44):3215-3226. PMID: 39285229 -
Int J Mol Med
miR‑223‑3p promotes microglial lactylation and M1 polarization via the FBXW7/Notch1/Hes1/SIRT1 axis. [Abstract]2026 Jul;58(1):178. PMID: 42138198 -
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Free Radic Biol Med
Salvianolic acid B drives gluconeogenesis and peroxisomal redox remodeling in cardiac ischemia/reperfusion injury: A metabolism regulation by metabolite signal crosstalk. [Abstract]2025 Mar 1:229:399-414. PMID: 39855316 -
Free Radic Biol Med
2024 Oct:223:473-492. PMID: 38992393 -
Free Radic Biol Med
BDNF mimetic 7,8-dihydroxyflavone rescues rotenone-induced cytotoxicity in cardiomyocytes by ameliorating mitochondrial dysfunction. [Abstract]2023 Mar:198:83-91. PMID: 36764626 -
EMBO Mol Med
Glycine decarboxylase advances IgA nephropathy by boosting mesangial cell proliferation through the pyrimidine pathway. [Abstract]2025 Oct 13. PMID: 41083822 -
Cancer Immunol Res
Herpes virus entry mediator costimulation signaling enhances CAR-T cell efficacy against solid tumors through metabolic reprogramming. [Abstract]2023 Apr 3;11(4):515-529. PMID: 36689620 -
Clin Transl Med
Protein arginine methyltransferase 3 promotes glycolysis and hepatocellular carcinoma growth by enhancing arginine methylation of lactate dehydrogenase A. [Abstract]2022 Jan;12(1):e686. PMID: 35090076 -
ACS Appl Mater Interfaces
Bioactive Light-Responsive Au Nanohybrids for Reactive Oxygen Species-Driven Macrophage Reprogramming. [Abstract]2025 Oct 1;17(39):54453-54465. PMID: 40956059 -
Stem Cell Res Ther
Genome editing of TXNIP in human pluripotent stem cells for the generation of hepatocyte-like cells and insulin-producing islet-like aggregates. [Abstract]2025 May 4;16(1):225. PMID: 40320524 -
Aging Cell
Dietary Citrate Restores Age-Related Endothelial Cell Mitochondrial Dysfunction and Alleviates Atherosclerosis. [Abstract]2025 Oct;24(10):e70213. PMID: 40905413 -
Cell Rep
TRIM65 as a key regulator of ferroptosis and glycolysis in lactate-driven renal tubular injury and diabetic kidney disease. [Abstract]2025 Jul 30;44(8):116091. PMID: 40748757 -
Cell Rep
2023 Aug 28;42(9):113044. PMID: 37643085 -
Cell Rep
Resolvin D1 reprograms energy metabolism to promote microglia to phagocytize neutrophils after ischemic stroke. [Abstract]2023 Jun 6;42(6):112617. PMID: 37285269 -
Front Immunol
The mTORC1 Signaling Support Cellular Metabolism to Dictate Decidual NK Cells Function in Early Pregnancy. [Abstract]2022 Mar 10;13:771732. PMID: 35359988 -
J Agric Food Chem
Elevated PINK1/Parkin-Dependent Mitophagy and Boosted Mitochondrial Function Mediate Protection of HepG2 Cells from Excess Palmitic Acid by Hesperetin. [Abstract]2024 Jun 12;72(23):13039-13053. PMID: 38809522 -
Ecotoxicol Environ Saf
Inhibition of mitochondrial calcium uptake by Ru360 enhances the effect of 1800 MHz radio-frequency electromagnetic fields on DNA damage. [Abstract]2023 Oct 1:264:115472. PMID: 37716072 -
Cell Mol Life Sci
m6A reader IGF2BP1 facilitates macrophage glycolytic metabolism and fibrotic phenotype by stabilizing THBS1 mRNA to promote pulmonary fibrosis. [Abstract]2025 Apr 12;82(1):157. PMID: 40220148 -
Life Sci
Aberrant interferon-γ signaling disrupts trophoblast invasion via IDO1/AHR signaling and metabolic reprogramming associated with recurrent pregnancy loss. [Abstract]2026 Apr 1:390:124256. PMID: 41655779 -
EMBO Rep
Defective branched-chain amino acid catabolism in dorsal root ganglia contributes to mechanical pain. [Abstract]2023 Nov 6;24(11):e56958. PMID: 37721527 -
Cancer Metab
PER2 knockdown drives immunotherapy resistance in gastric cancer via metabolic reprogramming of myeloid-derived suppressor cells. [Abstract]2026 Apr 2;14(1):13. PMID: 41928364 -
Cancer Metab
Unveiling the powerhouse: ASCL1-driven small cell lung cancer is characterized by higher numbers of mitochondria and enhanced oxidative phosphorylation. [Abstract]2025 Mar 31;13(1):16. PMID: 40165271 -
Cancer Metab
Tadalafil increases the antitumor activity of 5-FU through inhibiting PRMT5-mediated glycolysis and cell proliferation in colorectal cancer. [Abstract]2022 Dec 6;10(1):22. PMID: 36474242 -
Commun Biol
Mitochondrial protein Mrpl13 regulates zebrafish liver development through the mTORC1-mitochondrial homeostasis pathway. [Abstract]2026 Apr 30;9(1):909. PMID: 42062477 -
Mar Drugs
Antiproliferative Activity and Potential Mechanism of Marine-Sourced Streptoglutarimide H against Lung Cancer Cells. [Abstract]2021 Jan 31;19(2):79. PMID: 33572615 -
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Solvent & Solubility
In Vitro:
Ethanol : 30 mg/mL (Need ultrasonic and warming)
DMSO : 20 mg/mL (Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Protocols
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Kinase activity and phosphorylation assays
Kinase activity assays measure the ability of kinases to transfer phosphate groups from ATP to specific substrates, while phosphorylation assays detect the presence and levels of phosphorylated proteins. Common methods include radiolabeled ATP incorporation (e. g. ,), ADP release detection via bioluminescence (e. g. ,[3]), enzyme-linked immunosorbent assays (ELISA) for phospho-specific epitopes (e. g. ,[6]), and microtiter-based formats for high-throughput screening (e. g. ,[8]). The ADP-Glo assay quantifies kinase activity by measuring ADP produced during phosphorylation using a luciferase-based system. Radiometric assays involve autoradiography or scintillation counting after incorporation of 32P-labeled ATP into substrate proteins. ELISA-based approaches rely on phospho-specific antibodies to detect activated kinases in cell lysates or purified samples.
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Western Blot
Western blotting (WB) is a commonly used experimental method in molecular biology, biochemistry, and immunogenetics for identifying and quantifying target proteins. It combines gel electrophoresis with immunoassay, enabling researchers to analyze protein expression, post-translational modifications, and molecular weight.
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RNA extraction experimental
By lysing cells, releasing RNA, and removing impurities such as proteins and DNA, high-purity RNA products are finally obtained. The commonly used traditional method is the guanidine isothiocyanate/phenol/chloroform method (Trizol), which is suitable for a variety of animal materials including animal tissues, microorganisms, cultured cells, etc., and most plant materials.
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Protocol for Kinase activity and phosphorylation assays
Kinase activity assays measure transfer of phosphate from ATP to a protein or peptide substrate, generating phosphorylated substrate, ADP, or incorporated radiolabeled phosphate as the readout; phosphorylation assays measure site-specific phosphorylation in cells or tissues as a proxy for kinase-pathway activation, inhibition, or substrate regulation. Phosphorylation can be detected by phospho-specific Western blot, immunoprecipitation kinase assay, phospho-immunofluorescence, phospho-flow cytometry, luminescent ADP detection, radiolabeled ATP incorporation, or reporter-based pathway assays, and these readouts can be applied to cancer cells, primary neurons, mouse tumors, organoids, inflammatory macrophages, ferroptosis studies, and mitophagy studies when the kinase target is biologically relevant.
Purity & Documentation
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Data Sheet (273 KB)
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SDS (420 KB)
- English - EN (420 KB)
- Français - FR (420 KB)
- Deutsch - DE (420 KB)
- Norwegian - NO (420 KB)
- Español - ES (420 KB)
- Swedish - SV (420 KB)
- Italian - IT (420 KB)
- Korean - KR (420 KB)
- Portuguese - PT (420 KB)
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Handling Instructions (2659 KB)
References
[1]. Zhou W, et al. Membrane plasticity facilitates recognition of the inhibitor oligomycin by the mitochondrial ATP synthase rotor. Biochim Biophys Acta Bioenerg. 2018;1859(9):789-796. [Content Brief]
[2]. SMITH RM, et al. Oligomycin, a new antifungal antibiotic. Antibiot Chemother (Northfield). 1954;4(9):962-970. [Content Brief]
[3]. López de Figueroa P, et al. Autophagy activation and protection from mitochondrial dysfunction in human chondrocytes. Arthritis Rheumatol. 2015;67(4):966-976. [Content Brief]
[4]. Gong Y, et al. Oligomycin inhibits HIF-1alpha expression in hypoxic tumor cells. Am J Physiol Cell Physiol. 2005;288(5):C1023-C1029. [Content Brief]
[5]. Shchepina LA, et al. Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis. Oncogene. 2002;21(53):8149-8157. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Oligomycin Related Classifications
HY-N6782 Related Classifications
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