F16
Based on 1 Customer Validation
F16 is a potent growth inhibitor of the neu-overexpressing cells and also selectively inhibits proliferation of mammary epithelial as well as a variety of mouse mammary tumor and human breast cancer cell lines.
For research use only. We do not sell to patients.
- Purity: 99.94%
- CAS No.: 36098-33-6
- Formula: C16H15IN2
- Molecular Weight:362.21
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>100 μM
Compound: F16
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Cytotoxicity against human A549 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay
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[PMID: 38169372] |
| A549 | IC50 |
>60 μM
Compound: F16
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Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 38086195] |
| BEAS-2B | IC50 |
>100 μM
Compound: F16
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Cytotoxicity against human BEAS-2B cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human BEAS-2B cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay
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[PMID: 38169372] |
| HepG2 | IC50 |
>60 μM
Compound: F16
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Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 38086195] |
| L02 | IC50 |
>60 μM
Compound: F16
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Cytotoxicity against human HL7702 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human HL7702 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 38086195] |
| MCF7 | IC50 |
>100 μM
Compound: F16
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Cytotoxicity against human MCF7 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay
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[PMID: 38169372] |
| NCI-H1975 | IC50 |
>50 μM
Compound: F16
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Cytotoxicity against human NCI-H1975 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human NCI-H1975 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay
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[PMID: 38169372] |
| NCI-H446 | IC50 |
>60 μM
Compound: F16
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Antiproliferative activity against human NCI-H446 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human NCI-H446 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 38086195] |
| NCI-H460 | IC50 |
>50 μM
Compound: F16
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Cytotoxicity against human NCI-H460 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human NCI-H460 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay
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[PMID: 38169372] |
F16 (3 μM; 3 days/7 days) affects growth in several mouse and human cancer cell lines[1].
F16 arrests cell cycle and increases apoptosis in F16-sensitive EpH4-A6 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB231, MDA-MB435, MDA-MB436, MDA-MB453, MDA-MB-468, SKBR-3, MCF-7, T47D, ZR-75-1 cells and mouse mammary epithelial cell line NMuMG
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Concentration:3 μM
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Incubation Time:3 days/7 days
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Result:Displayed antiproliferative activity against both mouse and human breast cancer cells. The growth of the mouse fibrosarcoma cell lines derived from ras-transgenic mice was not affected.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 36098-33-6
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Appearance Solid
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Molecular Weight 362.21
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Formula C16H15IN2
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Color Yellow to orange
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SMILES
C[N+]1=CC=C(/C=C/C2=CNC3=C2C=CC=C3)C=C1.[I-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : ≥ 31 mg/mL (85.59 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : 1 mg/mL (2.76 mM; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (285 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Fantin VR et al. A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth. Cancer Cell. 2002 Jul;2(1):29-42. [Content Brief]
[2]. Fantin VR et al. F16, a mitochondriotoxic compound, triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell. Cancer Res. 2004 Jan 1;64(1):329-36. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol / DMSO | 1 mM | 2.7608 mL | 13.8041 mL | 27.6083 mL | 69.0207 mL |
| DMSO | 5 mM | 0.5522 mL | 2.7608 mL | 5.5217 mL | 13.8041 mL |
| 10 mM | 0.2761 mL | 1.3804 mL | 2.7608 mL | 6.9021 mL | |
| 15 mM | 0.1841 mL | 0.9203 mL | 1.8406 mL | 4.6014 mL | |
| 20 mM | 0.1380 mL | 0.6902 mL | 1.3804 mL | 3.4510 mL | |
| 25 mM | 0.1104 mL | 0.5522 mL | 1.1043 mL | 2.7608 mL | |
| 30 mM | 0.0920 mL | 0.4601 mL | 0.9203 mL | 2.3007 mL | |
| 40 mM | 0.0690 mL | 0.3451 mL | 0.6902 mL | 1.7255 mL | |
| 50 mM | 0.0552 mL | 0.2761 mL | 0.5522 mL | 1.3804 mL | |
| 60 mM | 0.0460 mL | 0.2301 mL | 0.4601 mL | 1.1503 mL | |
| 80 mM | 0.0345 mL | 0.1726 mL | 0.3451 mL | 0.8628 mL |
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