Cat. No.: HY-147651

β-catenin-IN-4

Customer Review

Based on 1 Customer Validation

β-catenin-IN-4 (Compound 39) is a β-catenin inhibitor with a K_i of 0.64 μM. β-catenin-IN-4 reduces the protein expression levels of cyclin D1 and c-Myc.

For research use only. We do not sell to patients.

Purity: 99.84%
CAS No.: 2353536-67-9
Formula: C₃₈H₃₃ClF₃N₅O₉
Molecular Weight:796.14

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

β-catenin-IN-4 Chemical Structure

CAS No.: 2353536-67-9

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Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

β-catenin-IN-4 (Compound 39) is a β-catenin inhibitor with a K_i of 0.64 μM. β-catenin-IN-4 reduces the protein expression levels of cyclin D1 and c-Myc^[1].

IC₅₀ & Target

K_i: 0.64 μM (β-catenin)^[1]

All CDK Isoforms :

Chemical Information

CAS No. 2353536-67-9
Appearance Solid
Molecular Weight 796.14
Formula C₃₈H₃₃ClF₃N₅O₉
Color White to off-white
SMILES

O=C(N[C@H](C(NC1=CC=C(C=C1)OC(F)(F)F)=O)CCC(O)=O)[C@@H](NC([C@@H](NC(C2=CC3=C(N2)C=CC(Cl)=C3)=O)CC4=CC=C5C=CC=CC5=C4)=O)CC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 150 mg/mL (188.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.2561 mL

6.2803 mL

12.5606 mL

5 mM

0.2512 mL

1.2561 mL

2.5121 mL

10 mM

0.1256 mL

0.6280 mL

1.2561 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. McCoy MA, et al. Biophysical Survey of Small-Molecule β-Catenin Inhibitors: A Cautionary Tale. J Med Chem. 2022 May 26;65(10):7246-7261. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.2561 mL	6.2803 mL	12.5606 mL	31.4015 mL
	5 mM	0.2512 mL	1.2561 mL	2.5121 mL	6.2803 mL
	10 mM	0.1256 mL	0.6280 mL	1.2561 mL	3.1402 mL
	15 mM	0.0837 mL	0.4187 mL	0.8374 mL	2.0934 mL
	20 mM	0.0628 mL	0.3140 mL	0.6280 mL	1.5701 mL
	25 mM	0.0502 mL	0.2512 mL	0.5024 mL	1.2561 mL
	30 mM	0.0419 mL	0.2093 mL	0.4187 mL	1.0467 mL
	40 mM	0.0314 mL	0.1570 mL	0.3140 mL	0.7850 mL
	50 mM	0.0251 mL	0.1256 mL	0.2512 mL	0.6280 mL
	60 mM	0.0209 mL	0.1047 mL	0.2093 mL	0.5234 mL
	80 mM	0.0157 mL	0.0785 mL	0.1570 mL	0.3925 mL
	100 mM	0.0126 mL	0.0628 mL	0.1256 mL	0.3140 mL

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β-catenin-IN-4

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High-Throughput Bioactive Compound Library

High-Efficiency Gene Editing Compound Library

All CDK Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

β-catenin-IN-4 Related Classifications

HY-147651 Related Classifications