2. Stem Cell/Wnt
  3. β-catenin
  4. β-catenin-IN-4

β-catenin-IN-4 (Compound 39) is a β-catenin inhibitor with a Ki of 0.64 μM. β-catenin-IN-4 reduces the protein expression levels of cyclin D1 and c-Myc.

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β-catenin-IN-4 Chemical Structure

β-catenin-IN-4 Chemical Structure

CAS No. : 2353536-67-9

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5 mg USD 200 In-stock
10 mg USD 320 In-stock
25 mg USD 640 In-stock
50 mg USD 1020 In-stock
100 mg USD 1580 In-stock
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Based on 1 publication(s) in Google Scholar

β-catenin-IN-4 Related Antibodies

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Description

β-catenin-IN-4 (Compound 39) is a β-catenin inhibitor with a Ki of 0.64 μM. β-catenin-IN-4 reduces the protein expression levels of cyclin D1 and c-Myc[1].

IC50 & Target

Ki: 0.64 μM (β-catenin)[1]
Molecular Weight

796.14

Formula

C38H33ClF3N5O9
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N[C@H](C(NC1=CC=C(C=C1)OC(F)(F)F)=O)CCC(O)=O)[C@@H](NC([C@@H](NC(C2=CC3=C(N2)C=CC(Cl)=C3)=O)CC4=CC=C5C=CC=CC5=C4)=O)CC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 150 mg/mL (188.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2561 mL 6.2803 mL 12.5606 mL
5 mM 0.2512 mL 1.2561 mL 2.5121 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2561 mL 6.2803 mL 12.5606 mL 31.4015 mL
5 mM 0.2512 mL 1.2561 mL 2.5121 mL 6.2803 mL
10 mM 0.1256 mL 0.6280 mL 1.2561 mL 3.1402 mL
15 mM 0.0837 mL 0.4187 mL 0.8374 mL 2.0934 mL
20 mM 0.0628 mL 0.3140 mL 0.6280 mL 1.5701 mL
25 mM 0.0502 mL 0.2512 mL 0.5024 mL 1.2561 mL
30 mM 0.0419 mL 0.2093 mL 0.4187 mL 1.0467 mL
40 mM 0.0314 mL 0.1570 mL 0.3140 mL 0.7850 mL
50 mM 0.0251 mL 0.1256 mL 0.2512 mL 0.6280 mL
60 mM 0.0209 mL 0.1047 mL 0.2093 mL 0.5234 mL
80 mM 0.0157 mL 0.0785 mL 0.1570 mL 0.3925 mL
100 mM 0.0126 mL 0.0628 mL 0.1256 mL 0.3140 mL
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β-catenin-IN-4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-catenin-IN-42353536-67-9β-cateninBeta cateninSW480cyclin D1c-MycInhibitorinhibitorinhibit

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