β-catenin-IN-4
Based on 1 Customer Validation
β-catenin-IN-4 (Compound 39) is a β-catenin inhibitor with a Ki of 0.64 μM. β-catenin-IN-4 reduces the protein expression levels of cyclin D1 and c-Myc.
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- Reinheit : 99.84%
- CAS. Nr.: 2353536-67-9
- Formel: C38H33ClF3N5O9
- Molecular Weight:796.14
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Speicherung:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
Ki: 0.64 μM (β-catenin)[1]
Chemical Information
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CAS. Nr. 2353536-67-9
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Appearance Solid
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Molecular Weight 796.14
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Formel C38H33ClF3N5O9
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Color White to off-white
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SMILES
O=C(N[C@H](C(NC1=CC=C(C=C1)OC(F)(F)F)=O)CCC(O)=O)[C@@H](NC([C@@H](NC(C2=CC3=C(N2)C=CC(Cl)=C3)=O)CC4=CC=C5C=CC=CC5=C4)=O)CC(O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 150 mg/mL (188.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Reinheit & Dokumentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2561 mL | 6.2803 mL | 12.5606 mL | 31.4015 mL |
| 5 mM | 0.2512 mL | 1.2561 mL | 2.5121 mL | 6.2803 mL | |
| 10 mM | 0.1256 mL | 0.6280 mL | 1.2561 mL | 3.1402 mL | |
| 15 mM | 0.0837 mL | 0.4187 mL | 0.8374 mL | 2.0934 mL | |
| 20 mM | 0.0628 mL | 0.3140 mL | 0.6280 mL | 1.5701 mL | |
| 25 mM | 0.0502 mL | 0.2512 mL | 0.5024 mL | 1.2561 mL | |
| 30 mM | 0.0419 mL | 0.2093 mL | 0.4187 mL | 1.0467 mL | |
| 40 mM | 0.0314 mL | 0.1570 mL | 0.3140 mL | 0.7850 mL | |
| 50 mM | 0.0251 mL | 0.1256 mL | 0.2512 mL | 0.6280 mL | |
| 60 mM | 0.0209 mL | 0.1047 mL | 0.2093 mL | 0.5234 mL | |
| 80 mM | 0.0157 mL | 0.0785 mL | 0.1570 mL | 0.3925 mL | |
| 100 mM | 0.0126 mL | 0.0628 mL | 0.1256 mL | 0.3140 mL |
β-catenin-IN-4 Related Classifications
HY-147651 Related Classifications
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