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  3. α-Linolenic acid

α-Linolenic acid 

Cat. No.: HY-N0728 Purity: >98.0%
Handling Instructions

α-Linolenic acid, isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer.

For research use only. We do not sell to patients.

α-Linolenic acid Chemical Structure

α-Linolenic acid Chemical Structure

CAS No. : 463-40-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 61 In-stock
Estimated Time of Arrival: December 31
10 mg USD 55 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

α-Linolenic acid, isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer[1].

IC50 & Target

PI3K

 

Akt

 

In Vitro

α-Linolenic acid converses into the longer chain fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)[1].

In Vivo

α-Linolenic acid (50, 100, 250 mg/kg; for 10 days) can completely inhibit collagen- and adrenaline-induced thrombosis in mice at 250 mg/kg[1].
α-Linolenic acid (35, 70, 175 mg/kg) suppresses A-V thrombus formation in rats (weighing at 250 ~ 300 g)[1].
α-Linolenic acid (70 or 175 mg/kg) inhibits collagen stimulated platelet aggregation in rats[1].

Animal Model: Mice weighing at 18 ~ 22 g[1]
Dosage: 50, 100, 250 mg/kg
Administration: For 10 days
Result: Completely inhibited collagen- and adrenaline-induced thrombosis at 250 mg/kg.
Molecular Weight

278.43

Formula

C₁₈H₃₀O₂

CAS No.

463-40-1

SMILES

CC/C=C\C/C=C\C/C=C\CCCCCCCC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

α-Linolenic acidPI3KAktPhosphoinositide 3-kinasePKBProtein kinase BSeedoilsessentialfattyacidthromboticanti-arrhythmiccardiovascularcancerInhibitorinhibitorinhibit

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α-Linolenic acid
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