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  3. α-Linolenic acid

α-Linolenic acid 

Cat. No.: HY-N0728 Purity: >98.0%
Handling Instructions

α-Linolenic acid, isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer.

For research use only. We do not sell to patients.

α-Linolenic acid Chemical Structure

α-Linolenic acid Chemical Structure

CAS No. : 463-40-1

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 61 In-stock
Estimated Time of Arrival: December 31
10 mg USD 55 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

α-Linolenic acid, isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer[1].

IC50 & Target[1]

PI3K

 

Akt

 

In Vitro

α-Linolenic acid converses into the longer chain fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)[1].

In Vivo

α-Linolenic acid (50, 100, 250 mg/kg; for 10 days) can completely inhibit collagen- and adrenaline-induced thrombosis in mice at 250 mg/kg[1].
α-Linolenic acid (35, 70, 175 mg/kg) suppresses A-V thrombus formation in rats (weighing at 250 ~ 300 g)[1].
α-Linolenic acid (70 or 175 mg/kg) inhibits collagen stimulated platelet aggregation in rats[1].

Animal Model: Mice weighing at 18 ~ 22 g[1]
Dosage: 50, 100, 250 mg/kg
Administration: For 10 days
Result: Completely inhibited collagen- and adrenaline-induced thrombosis at 250 mg/kg.
Molecular Weight

278.43

Formula

C₁₈H₃₀O₂

CAS No.

463-40-1

SMILES

CC/C=C\C/C=C\C/C=C\CCCCCCCC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (359.16 mM)

H2O : ≥ 100 mg/mL (359.16 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5916 mL 17.9578 mL 35.9157 mL
5 mM 0.7183 mL 3.5916 mL 7.1831 mL
10 mM 0.3592 mL 1.7958 mL 3.5916 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.98 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.98 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.98 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >98.0%

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Keywords:

α-Linolenic acidPI3KAktPhosphoinositide 3-kinasePKBProtein kinase BSeedoilsessentialfattyacidthromboticanti-arrhythmiccardiovascularcancerInhibitorinhibitorinhibit

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α-Linolenic acid
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