1. Cell Cycle/DNA Damage
    Autophagy
  2. Topoisomerase
    Autophagy
  3. Idarubicin hydrochloride

Idarubicin hydrochloride (Synonyms: 4-Demethoxydaunorubicin hydrochloride)

製品番号: HY-17381 純度: 99.82%
取扱説明書

Idarubicin hydrochloride is an anthracycline antileukemic drug. It inhibits the topoisomerase II interfering with the replication of DNA and RNA transcription.

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Idarubicin hydrochloride 構造式

Idarubicin hydrochloride 構造式

CAS 番号 : 57852-57-0

容量 価格(税別) 在庫状況 数量
10 mM * 1 mL in DMSO USD 78 在庫あり
Estimated Time of Arrival: December 31
5 mg USD 66 在庫あり
Estimated Time of Arrival: December 31
10 mg USD 115 在庫あり
Estimated Time of Arrival: December 31
50 mg USD 364 在庫あり
Estimated Time of Arrival: December 31
100 mg   お問い合わせ  
200 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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製品説明

Idarubicin hydrochloride is an anthracycline antileukemic drug. It inhibits the topoisomerase II interfering with the replication of DNA and RNA transcription.

IC50 & Target

DNA topoisomerase II[1]

体外実験

The IC50 of idarubicin is 3.3±0.4 ng/mL on MCF-7 monolayers and 7.9±1.1 ng/mL in multicellular spheroids[1]. Idarubicin has shown a greater cytotoxicity than daunorubicin or doxorubicin in various in vitro systems. This has been attributed to a better ability of idarubicin to induce the formation of topoisomerase II -mediated DNA breaks[2].Idarubicin is about 57.5-fold and 25-fold more active than doxorubicin and epirubicin, respectively[3]. Idarubicin produces a concentration-dependent reduction in cell growth, with an IC50 value of approximately 0.01 μM. Idarubicin produced a concentration-dependent inhibition of DNA synthesis[4].

臨床実験
分子量

533.95

分子式

C₂₆H₂₈ClNO₉

CAS 番号

57852-57-0

SMILES

OC(C(C(C1=CC=CC=C21)=O)=C3C2=O)=C4[[email protected]](C[[email protected]@](C(C)=O)(O)CC4=C3O)O[[email protected]@](O[[email protected]@H](C)[[email protected]]5O)([H])C[[email protected]@H]5N.Cl

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶剤 & 溶解度
体外: 

DMSO : ≥ 50 mg/mL (93.64 mM)

H2O : 6.67 mg/mL (12.49 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8728 mL 9.3642 mL 18.7283 mL
5 mM 0.3746 mL 1.8728 mL 3.7457 mL
10 mM 0.1873 mL 0.9364 mL 1.8728 mL
*Please refer to the solubility information to select the appropriate solvent.
体内:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.68 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.68 mM); Clear solution

*All of the co-solvents are provided by MCE.
参考文献
細胞実験
[1]

Stock solutions of idarubicin hydrochloride is dissolved in distilled water (1 mg/mL). MCF-7 monolayer are exposed to idarubicin or its metabolite idarubicinol at 0.01, 0.1, 1, 10, 100, and 1000 ng/mL for 24 hours. Multicellular spheroids are exposed to the same range of idarubicin and idarubicinol concentration as monolayers (0.01-1000 ng/mL) for 24 h and, in separate experiments, at the drug concentration of 100 ng/mL for 6, 12, 24 and 48 h. The inhibition of cell proliferation is determined by counting the viable cells with an hemocytometer. Results are expressed as percentage of cell survival vs. control cultures[1].

MCE はこれらの方法の精度を確認していません。 こちらは参照専用です。

参考文献

純度: 99.82%

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Keywords:

Idarubicin4-DemethoxydaunorubicinTopoisomeraseAutophagyInhibitorinhibitorinhibit

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製品名:
Idarubicin hydrochloride
製品番号:
HY-17381
数量:
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