ADC Payloads
ADC Cytotoxins
ADC payloads are cytotoxic agents that induce target cell death in Antibody Drug Conjugates (ADCs). An ADC is a targeted agent composed with a monoclonal antibody, a linker and a payload. The payload is the most important component as it determines the potency to kill cancer cells of an ADC.
There are many payloads which are currently being used such as Calicheamicins, Duocarmycins, Pyrrolobenzodiazepines (PBDs), Camptothecins, Daunorubicins/Doxorubicins, Auristatins and Maytansinoids. They can be divided in two classes based on their mechanism of action, DNA damaging agents and tubulin inhibitors. Among them Calicheamicins, Duocarmycins and PBDs are DNA minor grove binders, Camptothecins and Daunorubicins/Doxorubicins are topoisomerase inhibitors, which are DNA damaging agents. Auristatins and Maytansinoids are tubulin inhibitors.
ADC Payloads Isoform Specific Products
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ADC Payloads
(219)
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Auristatin
(15)
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Calicheamicins
(1)
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Camptothecins
(42)
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Daunorubicins/
Doxorubicins (11)View all products
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Duocarmycins
(18)
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Maytansinoids
(10)
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Pyrrolobenzodiazepines
(8)
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Traditional Cytotoxic Agents
(24)
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All Product Categories
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ADC Payloads Related Products (372)
Related Products (372)
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Antibodies (2)
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Related Compound Screening Libraries (1)
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ADC Payloads Isoform Comparison
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10-Methoxycamptothecin
0 Images10-Methoxycamptothecin is a natural bioactive derivative of camptothecin (CPT) isolated from Camptotheca acuminata, and has been confirmed to possess high anti-cancer properties. 10-Methoxycamptothecin has higher cytotoxicity than 10-hydroxycamptothecin by testing antitumor activity against 2774 cell lines.
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N-Ac-γ-Calicheamicin-AcBut-NHS ester
0 ImagesCat. No.: HY-103688CAS No.: 174885-02-0AcBut-N-Ac-γ-Calicheamicin is an ADC cytotoxic payload that induces cell cycle arrest and apoptosis by causing DNA double-strand breaks. AcBut-N-Ac-γ-Calicheamicin is primarily used in the synthesis of antibody-drug conjugates (ADC) and holds promise for research in the field of cancer, including acute lymphoblastic leukemia (ALL) and other hematological malignancies.
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7-Hydroxymethyl-10,11-MDCPT
0 ImagesCat. No.: HY-156756CAS No.: 428816-69-77-Hydroxymethyl-10,11-MDCPT is a hydrophilic camptothecin analog. 7-Hydroxymethyl-10,11-MDCPT is a payload that can be used for ADC synthesis.
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PNU-159682 carboxylic acid
0 ImagesCat. No.: HY-126666CAS No.: 1204819-92-0PNU-159682 carboxylic acid (Compound 53) is a potent ADCs cytotoxin and encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. PNU-159682 carboxylic acid has protein fold and diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response.
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Exatecan Intermediate 2 hydrochloride
0 ImagesExatecan Intermediate 2 hydrochloride (Compound B) is an intermediate of Exatecan (DX-8951, HY-13631). Exatecan is an anticancer agent belonging to the class of camptothecin analogs. Exatecan interferes with the proliferation and division of tumor cells by interacting with DNA, thereby inhibiting tumor growth. Exatecan is primarily used for research of a variety of cancers including ovarian, lung and breast cancers.
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Exatecan Intermediate 4
0 ImagesExatecan Intermediate 4 (Compound 14f) is an intermediate of Exatecan (DX-8951, HY-13631). Exatecan is an anticancer agent belonging to the class of camptothecin analogs. Exatecan interferes with the proliferation and division of tumor cells by interacting with DNA, thereby inhibiting tumor growth. Exatecan is primarily used for research of a variety of cancers including ovarian, lung and breast cancers.
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MMAF-d8 hydrochloride
0 ImagesCat. No.: HY-15579ASPurity: 99.52%MMAF-d8 (hydrochloride)e is a deuterated form of MMAF hydrochloride, which is a microtubule disrupting agent.
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PF-06380101-d8
0 ImagesSynonyms: Aur0101-d8; Auristatin-0101-d8PF-06380101-d8 (Aur0101-d8) is a deuterium labeled PF-06380101 (HY-12522). PF-06380101, an Auristatin microtubule inhibitor, is a cytotoxic Dolastatin 10 analogue.
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DC0-NH2
0 ImagesCat. No.: HY-129379CAS No.: 615538-51-7DC0-NH2 is an effector moiety for ADC and a simplified analog of DC1 with better stability. DC0-NH2 is about 1000-fold more cytotoxic than commonly used anticancer agents (ex. Doxorubicin). DC0-NH2 can bind to the minor groove of DNA, followed by alkylation of adenine residues by its propabenzindole (CBI) component.
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CC-885-CH2-PEG1-NH-CH3 TFA
0 ImagesCat. No.: HY-145449APurity: 99.26%CC-885-CH2-PEG1-NH-CH3 TFA is a new degrader that can be used to synthesize antibody-based novel degrader conjugated active molecules (AnDC). CC-885-CH2-PEG1-NH-CH3 TFA is the toxic molecule of ADC, which can specifically degrade the target protein in cancer cells through the E3 ubiquitin ligase pathway.
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Tomaymycin DM
0 ImagesCat. No.: HY-102001CAS No.: 945490-09-5Tomaymycin DM is a derivative of Tomaymycin (HY-N10174) that belongs to the class of DNA alkylation inhibitors and acts as an effective payload for ADCs. Tomaymycin stabilizes the double-stranded DNA structure, inhibits various DNA processing enzymes, blocks transcription, and ultimately induces DNA strand breaks and apoptosis. Tomaymycin DM can be used in studies related to the development of ADCs targeting multiple cancers including leukemia and ovarian cancer.
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Dox-btn2
0 ImagesSynonyms: Biotin Labeled DoxorubicinDox-btn2 is a biotin labeled Doxorubicin (HY-15142A), with a biotin label at the point of conjugation to doxorubicin at 3'-NH2. Dox-btn2 can be used for cell imaging. While Doxorubicin is mainly accumulated in the nucleus, while Dox-btn2 is mainly located in the cytoplasm.
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Exatecan Intermediate 3
0 ImagesExatecan Intermediate 3 is the intermediate of Exatecan (HY-13631) And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. Exatecan Intermediate 3 can be used to synthesize Antibody-Drug Conjugates (ADCs).
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Exatecan Intermediate 7
0 ImagesCat. No.: HY-45157CAS No.: 182182-32-7Exatecan Intermediate 7 is the intermediate of Exatecan (HY-13631) And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. Exatecan Intermediate 7 can be used to synthesize Antibody-Drug Conjugates (ADCs).
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Auristatin E-d8
0 ImagesCat. No.: HY-15582SPurity: 99.48%Auristatin E-d8 is the deuterium labeled Auristatin E (HY-15582). Auristatin E is a cytotoxic microtubule polymerization inhibitor with potent and selective antitumor activity. Auristatin E is a cytotoxin in antibody-drug conjugates (ADC). Auristatin E inhibits cell division by blocking the polymerisation of tubulin, promising for research in B-cell malignancies. Auristatin E, a synthetic analogue of the Dolastatin 10 (HY-15580), is linear peptides comprised of four amino acids.
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DM3
0 ImagesCat. No.: HY-130080CAS No.: 796073-54-6Synonyms: Maytansinoid DM3DM3 (Maytansinoid DM3), a Maytansine (HY-13674) analog bearing disulfide or thiol groups, and is a tubulin inhibitor. DM3 a cytotoxic moiety of antibody-drug conjugates (ADCs).
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Camptothecin derivative-3
0 ImagesCamptothecin derivative-3 (Compound 11) is a derivative of Camptothecin (HY-16560) and can serve as a payload for ADCs. Camptothecin derivative-3 has certain cytotoxicity, with IC50 values of 2 nM and 0.9 nM against HSC-2 and Namalwa/luc cells, respectively. Camptothecin derivative-3 can be used in tumor-related research.
