Phosphodiesterase (PDE)
Phosphodiesterase (PDE) is any enzyme that breaks a phosphodiester bond. Usually, people speaking of phosphodiesterase are referring to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below. However, there are many other families of phosphodiesterases, including phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases, as well as numerous less-well-characterized small-molecule phosphodiesterases. The cyclic nucleotide phosphodiesterases comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. PDEs are therefore important regulators ofsignal transduction mediated by these second messenger molecules.
Phosphodiesterase (PDE) Isoform Specific Products
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Phosphodiesterase (PDE)
(553)
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PDE1
(60)
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PDE2
(51)
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PDE3
(93)
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PDE4
(198)
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PDE5
(97)
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PDE6
(22)
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PDE7
(28)
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PDE9
(19)
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PDE10
(53)
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PDE11
(13)
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PDE12
(2)
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PDE8
(11)
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Autotaxin
(36)
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All Product Categories
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Phosphodiesterase (PDE) Inhibitors
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Phosphodiesterase (PDE) Agonists
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Phosphodiesterase (PDE) Antagonists
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Phosphodiesterase (PDE) Activators
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Phosphodiesterase (PDE) Modulators
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Phosphodiesterase (PDE) Degraders
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Phosphodiesterase (PDE) Controls
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Phosphodiesterase (PDE) Substrates
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Phosphodiesterase (PDE) Ligand
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Phosphodiesterase (PDE) Related Products (1009)
Related Products (1009)
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Antibodies (4)
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Phosphodiesterase (PDE) Isoform Comparison
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5,5′-(1,3-Propanediyl)bis-1,3,4-oxadiazole-2(3H)-thione
0 ImagesCat. No.: HY-141555CAS No.: 333409-31-75,5′-(1,3-Propanediyl)bis-1,3,4-oxadiazole-2(3H)-thione is a weak inhibitor for snake venom and human recombinant phosphodiesterase 1 with IC50 of 429 and 467 μM. 5,5′-(1,3-Propanediyl)bis-1,3,4-oxadiazole-2(3H)-thione inhibits mushroom tyrosinase weakly, with Ki of 1.9 μM.
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Mardepodect hydrochloride (Standard)
0 ImagesCat. No.: HY-50098ARCAS No.: 2070014-78-5Synonyms: PF-2545920 hydrochloride (Standard)Mardepodect (hydrochloride) (Standard) is the analytical standard of Mardepodect (hydrochloride). This product is intended for research and analytical applications. Mardepodect hydrochloride (PF-2545920 hydrochloride) is a potent, orally active and selective PDE10A inhibitor with an IC50 of 0.37 nM, with >1000-fold selectivity over other PDEs. Mardepodect hydrochloride can cross the blood-brain barrier.
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AY 17605
0 ImagesAY 17605 is a nucleoside-3':5'-monophosphate phosphodiesterase (Phosphodiesterase) inhibitor that blocks cAMP hydrolysis through non-competitive inhibition, thereby elevating intracellular cAMP levels. AY 17605 can be used in studies related to cardiotonic activity.
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Apremilast-d8
0 ImagesCat. No.: HY-12085S1CAS No.: 1258597-45-3Synonyms: CC-10004-d8Apremilast-d8 (CC-10004-d8) is deuterium labeled Apremilast. Apremilast (CC-10004) is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC50 of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC50 of 104 nM.
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Xanthoanthrafil
0 ImagesCat. No.: HY-136520BCAS No.: 1020251-53-9Xanthoanthrafil is a potent phosphodiesterase-5 (PDE5) inhibitor, with an IC50 of 3.95 ng/mL. Xanthoanthrafil can be used for the research of erectile dysfunction.
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Ro 20-1724 (Standard)
0 ImagesSynonyms: Ro 20-174 (Standard)Ro 20-1724 (Standard) is the analytical standard of Ro 20-1724. This product is intended for research and analytical applications. Ro 20-1724 (Ro 20-174) is a potent inhibitor of cAMP-specific phosphodiesterase (PDE4/PDE IV) with a Ki of 1930 nM. Neuroprotective effect.
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Nor-Acetildenafil (Standard)
0 ImagesCat. No.: HY-131101RCAS No.: 949091-38-7Nor-Acetildenafil (Standard) is the analytical standard of Nor-Acetildenafil. This product is intended for research and analytical applications. Nor-Acetildenafil is an Acetildenafil derivative. Acetildenafil is a synthetic agent which acts as a phosphodiesterase inhibitor.
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Meglumine cyclic adenylate
0 ImagesCat. No.: HY-188122CAS No.: 113960-50-2Meglumine cyclic adenylate is a cAMP analog. Meglumine cyclic adenylate promotes STAT3 phosphorylation at Ser727 and mitochondrial translocation. Meglumine cyclic adenylate inhibits cell apoptosis by reducing cytochrome c release and caspase-3 activation. Meglumine cyclic adenylate suppresses the expression of NF-κBp65, activates adenylate cyclase 3, and inhibits phosphodiesterase 4D. Meglumine cyclic adenylate enhances myocardial contractility, increases myocardial Ca2+ influx, dilates peripheral blood vessels, improves hypotension and bradycardia, promotes spinal cord function recovery, and regulates fear extinction and anxiety-like behaviors. Meglumine cyclic adenylate can be used in research related to cerebral ischemia/reperfusion injury, systemic inflammatory response syndrome, acute T4 thoracic spinal cord injury, and post-traumatic stress disorder (PTSD).
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BIO-32546 (Standard)
0 ImagesCat. No.: HY-103035RCAS No.: 1548743-66-3
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Hedgehog IN-8
0 ImagesCat. No.: HY-W838042CAS No.: 314041-83-3
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SCH 51866
0 ImagesCat. No.: HY-116262CAS No.: 167298-74-0SCH 51866 is a potent, selective and orally active inhibitor of PDE1 (IC50=70 nM) and PDE5 (IC50=60 nM). SCH 51866 inhibits collagen-induced aggregation of human washed platelets (IC50=10 μM), prevents neointimal formation in balloon catheter-injured carotid arteries of spontaneously hypertensive rats (SHR), and reduces blood pressure in SHR. SCH 51866 can be used in the study of hypertension.
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Pinoresinol 4-O-β-D-glucopyranoside (Standard)
0 ImagesCat. No.: HY-N2168RCAS No.: 69251-96-3Synonyms: (+)-Pinoresinol 4-O-β-D-glucopyranoside (Standard)Pinoresinol 4-O-β-D-glucopyranoside (Standard) is the analytical standard of Pinoresinol 4-O-β-D-glucopyranoside (HY-N2168). This product is intended for research and analytical applications. Pinoresinol 4-O-β-D-glucopyranoside is an orally active α-glucosidase inhibitor, with an IC50 of 48.13 μg/mL. Pinoresinol 4-O-β-D-glucopyranoside binds to estrogen receptors. Pinoresinol 4-O-β-D-glucopyranoside inhibits phosphodiesterase. Pinoresinol 4-O-β-D-glucopyranoside exhibits various activities such as antioxidant, anti-inflammatory, anti-hyperglycemic, hepatoprotective and anti-epileptic effects.
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PF-05085727 (Standard)
0 ImagesPF-05085727 (Standard) is the analytical standard of PF-05085727 (HY-102050). This product is intended for research and analytical applications. PF-05085727 is a potent, selective and brain penetrant inhibitor of cGMP-dependent PDE2A (IC50=2 nM). PF-05085727 inhibits PDE2A >4,000-fold selectivity over PDE1 and PDE3-11.
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Pyrazole N-Desmethyl sildenafil
0 ImagesCat. No.: HY-172297CAS No.: 139755-95-6Pyrazole N-Desmethyl sildenafil (Compound 10) is an analog of Sildenafil (HY-15025). Pyrazole N-Desmethyl sildenafil shows 16% inhibition on Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1) with 100 µM.
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Cyclic-DAP
0 ImagesCat. No.: HY-177991CAS No.: 52216-42-9Cylic-DAP is a substrate of spleen cyclic phosphodiesterase. Cylic-DAP undergoes degradation by spleen cyclic phosphodiesterase to form the corresponding 2'-nucleotide.
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Mardepodect (Standard)
0 ImagesSynonyms: PF-2545920 (Standard)Mardepodect (Standard) is the analytical standard of Mardepodect. This product is intended for research and analytical applications. Mardepodect (PF-2545920) is a potent, orally active and selective PDE10A inhibitor with an IC50 of 0.37 nM, with >1000-fold selectivity over other PDEs. Mardepodect can cross the blood-brain barrier.
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AWD 12-281
0 ImagesSynonyms: GW 842470AWD 12-281 is an orally active and highly selective phosphodiesterase 4 (PDE4) inhibitor (IC50 = 9.7 nM). AWD 12-281 is used in the study of allergic dermatitis, asthma, chronic obstructive pulmonary disease (COPD), and allergic rhinitis.
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Tetomilast (Standard)
0 ImagesCat. No.: HY-105092RCAS No.: 145739-56-6Synonyms: OPC-6535 (Standard)Tetomilast (Standard) is the analytical standard of Tetomilast (HY-105092). This product is intended for research and analytical applications. Tetomilast (OPC-6535) is a PDE4 inhibitor with potential for the research of inflammatory bowel disease (IBD) and chronic obstructive pulmonary disease (COPD).
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Amipizone
0 ImagesCat. No.: HY-118611CAS No.: 69635-63-8Amipizone is a cardiotoxic pyridazinone derivative. A variety of pyridazinone compounds are proven to inhibit cardiac type III phosphodiesterase (PDE3). Amipizone is applicable to the research of cardiovascular diseases.
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CP671305 (Standard)
0 ImagesCat. No.: HY-101803RCAS No.: 445295-04-5
