Phosphodiesterase (PDE)
Phosphodiesterase (PDE) is any enzyme that breaks a phosphodiester bond. Usually, people speaking of phosphodiesterase are referring to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below. However, there are many other families of phosphodiesterases, including phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases, as well as numerous less-well-characterized small-molecule phosphodiesterases. The cyclic nucleotide phosphodiesterases comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. PDEs are therefore important regulators ofsignal transduction mediated by these second messenger molecules.
Phosphodiesterase (PDE) Isoform Specific Products
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Phosphodiesterase (PDE)
(553)
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PDE1
(60)
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PDE2
(51)
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PDE3
(93)
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PDE4
(198)
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PDE5
(97)
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PDE6
(22)
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PDE7
(28)
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PDE9
(19)
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PDE10
(53)
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PDE11
(13)
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PDE12
(2)
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PDE8
(11)
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Autotaxin
(36)
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All Product Categories
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Phosphodiesterase (PDE) Inhibitors
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Phosphodiesterase (PDE) Agonists
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Phosphodiesterase (PDE) Antagonists
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Phosphodiesterase (PDE) Activators
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Phosphodiesterase (PDE) Modulators
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Phosphodiesterase (PDE) Degraders
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Phosphodiesterase (PDE) Controls
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Phosphodiesterase (PDE) Substrates
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Phosphodiesterase (PDE) Ligand
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Phosphodiesterase (PDE) Produits associés (1009)
Produits associés (1009)
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Anticorps (4)
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Phosphodiesterase (PDE) Isoform Comparison
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Amrinone (Standard)
0 ImagesCat. No.: HY-B1294RCAS No.: 60719-84-8Synonyms: Inamrinone (Standard)Amrinone (Standard) is the analytical standard of Amrinone. This product is intended for research and analytical applications. Amrinone (Inamrinone) is a positive inotropic-vasodilator agent. Amrinone is a selective phosphodiesterase III inhibitor that increases cyclic adenosine monophosphate by preventing its breakdown. Amrinone is also an orally active, non-glycosidic and non-catecholamine cardiotonic agent.
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Y-590
0 ImagesCat. No.: HY-123366CAS No.: 70386-06-0Y-590 is an orally active platelet cyclic adenosine monophosphate phosphodiesterase (cAMP-PDE) inhibitor with an IC50 of 0.9 nM against rabbit cAMP-PDE. Y-590 inhibits platelet aggregation, disaggregates aggregated platelets, suppresses collagen-induced platelet release, reduces platelet retention and inhibits cAMP degradation in platelets. Y-590 enhances PGI2-mediated elevation of intracellular cAMP in platelets and exerts a synergistic effect with PGI2 on ADP-induced platelet aggregation. Y-590 can be used in studies related to thrombotic diseases and thrombosis.
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Ibudilast-d3
0 ImagesCat. No.: HY-B0763SCAS No.: 102064-45-9Ibudilast-d3 (KC-404-d3) is the deuterium labeled Ibudilast. Ibudilast (KC-404) is a cyclic AMP phosphodiesterase (PDE) inhibitor. Ibudilast has platelet anti-aggregatory effects. Ibudilast can be used for the research of asthma for its inhibitory effects on tracheal smooth muscle contractility. Ibudilast may be a useful neuroprotective and anti-dementia agent counteracting neurotoxicity in activated microglia.
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PF-05180999 (Standard)
0 ImagesCat. No.: HY-111371RCAS No.: 1394033-54-5Synonyms: PF-999 (Standard)PF-05180999 (Standard) is the analytical standard of PF-05180999 (HY-111371). This product is intended for research and analytical applications. PF-05180999 (PF-999) is a phosphodiesterase 2A (PDE2A) inhibitor, with an IC50 of 1.6 nM.
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Vardenafil hydrochloride (Standard)
0 ImagesVardenafil (hydrochloride) (Standard) is the analytical standard of Vardenafil (hydrochloride). This product is intended for research and analytical applications. Vardenafil hydrochloride is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5), with an IC50 of 0.7 nM. Vardenafil hydrochloride shows inhibitory towards PDE1, PDE6 with IC50s of 180 nM, and 11 nM, while IC50s are >1000 nM for PDE3 and PDE4. Vardenafil hydrochloride competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Vardenafil hydrochloride can be used for the research of erectile dysfunction, hepatitis, diabetes-.
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Propentofylline-d6
0 ImagesCat. No.: HY-107203SCAS No.: 1216516-37-8Synonyms: HWA 285-d6Propentofylline-d6 (HWA 285-d6) is the deuterium labeled Propentofylline. Propentofylline is an orally active and brain-penetrant phosphodiesterase inhibitor. Propentofylline blocks adenosine reuptake and prevents cyclic nucleotide degradation. Propentofylline can be used for the research of primary degenerative (Alzheimer's) dementia, vascular dementia, cerebral ischemia, acute stroke, and learning and memory disorders.
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Olprinone hydrochloride solution
0 ImagesCat. No.: HY-FL14254BCAS No.: 2072803-95-1Synonyms: Loprinone hydrochloride hydrate solutionOlprinone hydrochloride solution is mainly composed of Olprinone hydrochloride hydrate (HY-14254B). Olprinone hydrochloride hydrate is a potent phosphodiesterase (PDE) 3 inhibitor, with IC50s of 150, 100, 0.35 and 14 μM for PDE1, PDE2, PDE3 and PDE4, respectively. Olprinone hydrochloride hydrate has anti-inflammatory activity, and is used for the research of heart failure due to its positive inotropic and vasodilative effects. Anti-inflammatory activity
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Lunamarine
0 ImagesLunamarine is a inhibitor of PDE5 with BBB permeability. Lunamarine can be used in the reseach of Pulmonary Arterial Hypertension (PAH) and Erectile Dysfunction (ED).
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FR-229934 (Standard)
0 ImagesFR-229934 (Standard) is the analytical standard of FR-229934 (HY-105686). This product is intended for research and analytical applications. FR-229934 is a PDE V inhibitor extracted from patent WO2019130052A1. FR-229934 can be used for the research of pulmonary arterial hypertension and erectile dysfunction.
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BRL-50481 (Standard)
0 ImagesCat. No.: HY-109586RCAS No.: 433695-36-4
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UK 357903
0 ImagesCat. No.: HY-19420CAS No.: 247580-98-9UK 357903 is a selective inhibitor for phosphodiesterase 5 (PDE5), with IC50s of 1.7 and 714 nM, for PDE5 and PDE6. UK 357903 exhibits vasodilatory effects on the mesenteric and hindlimb vascular beds, and is potential for ameliorating erectile dysfunction.
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Tibenelast sodium (Standard)
0 ImagesSynonyms: LY 186655 (Standard)Tibenelast sodium (Standard) is the analytical standard of Tibenelast sodium (HY-101705). This product is intended for research and analytical applications. Tibenelast sodium is a phosphodiesterase inhibitor.
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Cartazolate
0 ImagesCat. No.: HY-183471CAS No.: 34966-41-1Synonyms: SQ 65396Cartazolate (SQ 65396) is a pyrazolopyridine modulator with benzodiazepine receptor agonist activity and cyclic AMP phosphodiesterase inhibitory activity. Cartazolate enhances the affinity of 3H-diazepam for brain-specific binding sites, regulates the GABA/benzodiazepine receptor complex, reversibly increases Na+-independent GABA receptor binding sites, and stimulates the binding of [3H]flunitrazepam to cerebellar membranes. Cartazolate restores punishment-suppressed behavior and exhibits anxiolytic properties. Cartazolate is applicable to anxiety-related research.
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PDE4-IN-25
0 ImagesCat. No.: HY-W787896CAS No.: 346440-86-6PDE4-IN-25 (compound 12) is a potent inhibitor of PDE4，with the IC50 of 0.1 μM. PDE4-IN-25 plays an important role in inflammatory diseases research.
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Andolast free base (Standard)
0 ImagesSynonyms: CR 2039 free base (Standard); Dizolast free base (Standard)Andolast (free base) (Standard) is the analytical standard of Andolast (free base). This product is intended for research and analytical applications. Andolast (CR 2039) (free base) is an anti-allergic agent. Andolast can inhibit cAMP-phosphodiesterase with an IC50 value of 50 μM. Andolast can be used for the research of asthma.
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LEO 29102
0 ImagesCat. No.: HY-12348CAS No.: 1035572-38-3LEO 29102 is a potent phosphodiesterase 4 (PDE4) inhibitor with an IC50 value of 5 nM. LEO 29102 inhibits TNFα release. LEO 29102 has the potential for the research of atopic dermatitis.
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Doxofylline (Standard)
0 ImagesDoxofylline (Standard) is the analytical standard of Doxofylline. This product is intended for research and analytical applications. Doxofylline is an orally active PDE IV inhibitor and A1AR antagonist. Doxofylline reduces inflammation in epithelial cells via inhibiting mitochondrial ROS production and amelioration of multiple cellular pathways (NLRP3-TXNIP inflammasome activation). Doxophylline can be used in studies of asthma, chronic obstructive pulmonary disease, and bronchospasm.
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Homo Sildenafil-d5
0 ImagesCat. No.: HY-131100SCAS No.: 1216711-61-3Homo Sildenafil-d5 is the deuterium labeled Homo Sildenafil. Homo Sildenafil, an analog of Sildenafil, acts as a phosphodiesterase inhibitor.
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Desethyl sildenafil
0 ImagesCat. No.: HY-133991CAS No.: 139755-91-2Synonyms: Sildenafil impurity CDesethyl Sildenafil (Sildenafil impurity C) is the impurity of Sildenafil (HY-15025). Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM.
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2'-O-MB-cGMP sodium
0 ImagesCat. No.: HY-131764CAS No.: 58329-72-9Synonyms: 2′-O-Monobutyryl-cGMP sodium2'-O-MB-cGMP (2′-O-Monobutyryl-cGMP) sodium is a cyclic GMP-specific phosphodiesterase inhibitor with an I50 value of 35 µM. 2'-O-MB-cGMP (2′-O-Monobutyryl-cGMP) sodium inhibits Ca2+ dependent phosphodiesterase hydrolysis using cAMP or cGMP as substrate.
