Phosphodiesterase (PDE)
Phosphodiesterase (PDE) is any enzyme that breaks a phosphodiester bond. Usually, people speaking of phosphodiesterase are referring to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below. However, there are many other families of phosphodiesterases, including phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases, as well as numerous less-well-characterized small-molecule phosphodiesterases. The cyclic nucleotide phosphodiesterases comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. PDEs are therefore important regulators ofsignal transduction mediated by these second messenger molecules.
Phosphodiesterase (PDE) Isoform Specific Products
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Phosphodiesterase (PDE)
(553)
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PDE1
(60)
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PDE2
(51)
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PDE3
(93)
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PDE4
(198)
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PDE5
(97)
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PDE6
(22)
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PDE7
(28)
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PDE9
(19)
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PDE10
(53)
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PDE11
(13)
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PDE12
(2)
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PDE8
(11)
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Autotaxin
(36)
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All Product Categories
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Phosphodiesterase (PDE) Inhibitors
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Phosphodiesterase (PDE) Agonists
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Phosphodiesterase (PDE) Antagonists
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Phosphodiesterase (PDE) Activators
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Phosphodiesterase (PDE) Modulators
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Phosphodiesterase (PDE) Degraders
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Phosphodiesterase (PDE) Controls
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Phosphodiesterase (PDE) Substrates
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Phosphodiesterase (PDE) Ligand
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Phosphodiesterase (PDE) Related Products (1009)
Related Products (1009)
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Antibodies (4)
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Phosphodiesterase (PDE) Isoform Comparison
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Bis(4-nitrophenyl) phosphate (Standard)
0 ImagesCat. No.: HY-W013205RCAS No.: 645-15-8Synonyms: BNPP (Standard)Bis(4-nitrophenyl) phosphate (Standard) is the analytical standard of Bis(4-nitrophenyl) phosphate. This product is intended for research and analytical applications. Bis(4-nitrophenyl) phosphate (BNPP) is an esterase inhibitor, inhibits the activity of esterases such as carboxylesterase. Bis(4-nitrophenyl) phosphate inhibits the degradation of Abiraterone in fresh plasma. Bis(4-nitrophenyl) phosphate can be used as a substrate to determine the enzymatic activity of phosphodiesterase in the roots of wetland plants. Bis(4-nitrophenyl) phosphate also acts as a catalyst for metallomicelles and a catalyst that promotes ring-opening polymerization (ROP).
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Levosimendan (Standard)
0 ImagesSynonyms: Simsndan (Standard); OR-1259 (Standard); (4R)-Simendan (Standard)Levosimendan (Standard) is the analytical standard of Levosimendan. This product is intended for research and analytical applications. Levosimendan (Simsndan; OR-1259) is a calcium sensitiser used in the management of acutely decompensated congestive heart failure.
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NPD-039
0 ImagesCat. No.: HY-167233CAS No.: 2229043-40-5NPD-039 is a selective tetrahydrophthalazinone-class TbrPDEB1 inhibitor with a Ki of 99 nM. NPD-039 occupies the hydrophobic clamp and the parasite-specific P-pocket of TbrPDEB1, and its glycinamide tail forms direct and water-mediated hydrogen bond interactions within the P-pocket. NPD-039 can be used in related research on Human African Trypanosomiasis.
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PDE11A modulator-1
0 ImagesCat. No.: HY-180869CAS No.: 312634-95-0PDE11A modulator-1 is a PDE11A modulator.
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Difamilast (Standard)
0 ImagesSynonyms: OPA-15406 (Standard)Difamilast (Standard) is the analytical standard of Difamilast. This product is intended for research and analytical applications. Difamilast (OPA-15406) is a topical, selective and nonsteroidal phosphodiesterase-4 (PDE4) inhibitor with particularly efficient inhibition of subtype B (IC50=11.2 nM). Difamilast can be used for the research of mild to moderate atopic dermatitis (AD).
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CI-930
0 ImagesCat. No.: HY-183455CAS No.: 86798-59-6CI-930 is a selective, orally active phosphodiesterase 3 (PDE3) inhibitor with an IC50 value of 0.0.84 μM. CI-930 exerts positive inotropic and vasodilatory effects by inhibiting cAMP hydrolysis. CI-930 also regulates hemodynamics, inhibits the proliferation of coronary artery smooth muscle cells, and suppresses the proliferation of mouse splenocytes. CI-930 can be used in research related to heart failure, atherosclerosis, and asthma.
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Nicotinamide 1,N6-ethenoadenine dinucleotide (solution)
0 ImagesCat. No.: HY-DY1108CAS No.: 38806-38-1Synonyms: ε-NAD (solution)Nicotinamide 1,N6-ethenoadenine dinucleotide (solution) (ε-NAD (solution)) is a fluorescent analog of NAD. Nicotinamide 1,N6-ethenoadenine dinucleotide can be cleaved by phosphodiesterase I (from C. adamanteus venom) and binds to bovine liver glutamate dehydrogenase. Nicotinamide 1,N6-ethenoadenine dinucleotide can serve as a substrate for G-ADP ribosylation of G proteins catalyzed by bacterial toxins. Nicotinamide 1,N6-ethenoadenine dinucleotide can be used as a fluorescent substrate for the study of ADP ribosylation reactions.
Solvent and concentration: ddH2O: 20 mM
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RS14203
0 ImagesCat. No.: HY-69317CAS No.: 159925-31-2Synonyms: PMNPQRS14203 is an orally active type IV cyclic nucleotide phosphodiesterase (PDE IV) inhibitor which can induce emesis.
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PDE5-IN-7 (Standard)
0 ImagesPDE5-IN-7 (Standard) is the analytical standard of PDE5-IN-7 (HY-W011336). This product is intended for research and analytical applications. PDE5-IN-7 (compound 8) is a selective phosphodiesterase 5 (PDE 5) inhibitor with an IC50 value of 5 nM, while an IC50 of 300 nM for PDE 1.
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BML-288
0 ImagesCat. No.: HY-114023CAS No.: 851681-89-5BML-288 (compound Oxindole 1) is a potent PDE2 inhibitor with an IC50 value of 40 nM. BML-288 has the potential for the research of osteoarthritis pain.
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W-7 hydrochloride (Standard)
0 ImagesCat. No.: HY-100912RCAS No.: 61714-27-0W-7 (hydrochloride) (Standard) is the analytical standard of W-7 (hydrochloride) (HY-100912). This product is intended for research and analytical applications. W-7 hydrochloride is a selective calmodulin antagonist. W-7 hydrochloride inhibits the Ca2+-calmodulin-dependent phosphodiesterase and myosin light chain kinase with IC50 values of 28 μM and 51 μM, respectively. W-7 hydrochloride induces apoptosis and has antitumor and vascular relaxing activity. W-7 hydrochloride is a blocker of Kv4.3 and can be used for research of arrhythmias.
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Propoxyphenyl Aildenafil
0 ImagesCat. No.: HY-131383CAS No.: 1391053-82-9Propoxyphenyl Aildenafil is a Sildenafil analogue. Propoxyphenyl Aildenafil can be used for the research of enhancement of sexual function.
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Oxagrelate
0 ImagesCat. No.: HY-116850CAS No.: 56611-65-5Synonyms: EG626; Phthalazinol; SC-32840Oxagrelate is a specific inhibitor of cyclic adenosine monophosphate phosphodiesterase and exhibits concentration-dependent inhibition of collagen- and ADP-induced platelet aggregation in vitro.
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UK-371800
0 ImagesCat. No.: HY-19446CAS No.: 247582-13-4UK-371800 is a highly selective PDE5 inhibitor (IC50 = 4.2 nM). UK-371800 has good permeability and is not affected by the efflux of P-glycoprotein.
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PDE-IN-3
0 ImagesCat. No.: HY-W171611CAS No.: 56344-53-7PDE-IN-3 (compound 23) is a phosphodiesterase (PDE) inhibitor with an IC50 of 260 μM.
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(S)-BAY 73-6691 (Standard)
0 ImagesCat. No.: HY-104028BRCAS No.: 794568-91-5(S)-BAY 73-6691 (Standard) is the analytical standard of (S)-BAY 73-6691 (HY-104028B). This product is intended for research and analytical applications. (S)-BAY 73-6691 is the isomer of BAY 73-6691 (HY-104028), and can be used as an experimental control. BAY 73-6691 ((R)-BAY 73-6691) is a potent, brain penetrant, and selective PDE9A inhibitor.
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Cilostamide (Standard)
0 ImagesSynonyms: OPC3689 (Standard)Cilostamide (Standard) is the analytical standard of Cilostamide. This product is intended for research and analytical applications. Cilostamide is a selective and potent PDE3 inhibitor, with IC50s of 27 nM and 50 nM for PDE3A and PDE3B, respectively, and has antithrombotic and anti-intimal hyperplastic activity.
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Mesembrenol
0 ImagesCat. No.: HY-124482CAS No.: 25516-15-8Mesembrenol is an alkaloid inhibitor of serotonin transporters and PDE4. Mesembrenol also inhibits glutamatergic AMPA receptors and can be used in research on mild to moderate depression.
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Efmirenpase alfa
0 ImagesCat. No.: HY-P991677CAS No.: 2770242-54-9Synonyms: INZ-701Efmirenpase alfa is an Fc-ENPP1 fusion protein (human IgG1 Fc domain linked to a modified human ENPP1). Efmirenpase alfa has prolonged half-life and enhanced receptor affinity compared with native human ENPP1. Efmirenpase alfa can be used as an enzyme replacement therapy for ENPP1 deficiency such as arterial calcification and hypophosphatemic rickets research.
