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Acyclovir hydrochloride

(Synonyms: Aciclovir hydrochloride; Acycloguanosine hydrochloride)
22 Cited Publications
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Based on 22 publication(s) in Google Scholar

Acyclovir (Aciclovir) hydrochloride is a potent, orally active antiviral agent. Acyclovir hydrochloride has antiherpetic activity with IC50 values of 0.85 μM and 0.86 μM for HSV-1 and HSV-2, respectively. Acyclovir hydrochloride induces cell cycle perturbation and apoptosis. Acyclovir hydrochloride prevents bacterial infections during induction therapy for acute leukaemia.

For research use only. We do not sell to patients.

  • CAS No.: 1628039-62-2
  • Formula: C8H12ClN5O3
  • Molecular Weight:261.67
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Acyclovir hydrochloride Chemical Structure
    Acyclovir hydrochloride Chemical Structure
  • Experimental Validation Results for Acyclovir hydrochloride
  • Experimental Validation Results for Acyclovir hydrochloride
  • Experimental Validation Results for Acyclovir hydrochloride
  • Experimental Validation Results for Acyclovir hydrochloride
  • Experimental Validation Results for Acyclovir hydrochloride
CAS No.: 1628039-62-2
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Cell Imaging/StainingCell Proliferation/Viability AssayBio/Physico-chemical AssayWB
  • Cell Proliferation/Viability Assay
  • Cell Imaging/Staining
  • Bio/Physico-chemical Assay
  • Cell Proliferation/Viability Assay
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  • Acyclovir hydrochloride Chemical Structure
    Acyclovir hydrochloride Chemical Structure
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    Acyclovir hydrochloride purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2026 Feb:151:157802. [Abstract]

    Customer Validation
     The antiviral activity of Acyclovir (ACV) against HSV-1 in different cell cultures was evaluated using the CPE inhibition assay (MOI = 1).

  • 1/16

    Acyclovir hydrochloride purchased from MedChemExpress. Usage Cited in: Sci Adv. 2025 Nov 21;11(47):eadw4206. [Abstract]

    Customer Validation
     Fluorescence microscopy images depicting N2a cells infected with different doses of HuBXY/2018-mCherry with or without Acyclovir (ACV: 200 μM) and IFN-α treatments. The images were acquired on 8 dpi.

  • 1/16

    Acyclovir hydrochloride purchased from MedChemExpress. Usage Cited in: EMBO J. 2025 Apr;44(7):2157-2182. [Abstract]

    Customer Validation
     HeLa SIRF biosensor cells were analyzed 24 hours after being treated with a simulated method or infected with 0.5 MOI of HSV-1 virus expressing mCherry, with or without Acyclovir (50 µM).

  • 1/16

    Acyclovir hydrochloride purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2024 Nov;45(11):2380-2393. [Abstract]

    Customer Validation
     Acyclovir (2 μM). The inhibitory effect of J1 on HSV1 (MOI = 0.1) infection in Vero cells was analyzed by plaque assay.

  • 1/16

    Acyclovir hydrochloride purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2023 Jun:162:114595. [Abstract]

    Customer Validation
     Acyclovir (ACV; 2.5 μM; 48 h) significantly inhibits the expression of gD in HSV-2-infected HeLa, Vero, Beas-2B and HaCaT cells.

  • Acyclovir hydrochloride