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Art. -Nr.: HY-103492

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CDK8-IN-1

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CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC₅₀ of 3 nM.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 98.19%
CAS. Nr.: 1629633-48-2
Formel: C₁₁H₈F₃N₃O
Molecular Weight:255.20

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

CDK8-IN-1 Chemical Structure

CAS. Nr.: 1629633-48-2

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Protokoll
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC₅₀ of 3 nM.

IC₅₀ & Target^[1]

CDK8

3 nM (IC₅₀)

Alle CDK Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
AGS	IC₅₀	0.27 μM Compound: 16	Antiproliferative activity against human AGS cells after 72 hrs by MTT assay Antiproliferative activity against human AGS cells after 72 hrs by MTT assay	[PMID: 28802632]

In Vivo

CDK8-IN-1 displays low systemic clearance, very good exposure and oral bioavailability. The t_max is 0.25 h by PO. The mean values of C_max are 9940 μg/L, 12740 μg/L by IV and PO respectively. The values of AUC are 9378, 25952 by IV and PO respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1629633-48-2
Appearance Solid
Molecular Weight 255.20
Formel C₁₁H₈F₃N₃O
Color White to light brown
SMILES

NC(C1=C(C(F)(F)F)C(C2=CC=NC=C2)=CN1)=O
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (391.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.9185 mL

19.5925 mL

39.1850 mL

5 mM

0.7837 mL

3.9185 mL

7.8370 mL

10 mM

0.3918 mL

1.9592 mL

3.9185 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Protokoll

Animal Administration^[1]

Mice^[1]
CDK8-IN-1 is administrated to mice with 5 mg/kg, 25mg/mg by IV and PO respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)

SDS (251 KB)

English - EN (251 KB)

Français - FR (251 KB)

Deutsch - DE (251 KB)

Norwegian - NO (251 KB)

Español - ES (251 KB)

Swedish - SV (251 KB)

Italian - IT (251 KB)

Korean - KR (251 KB)

Portuguese - PT (251 KB)

COA (2659 KB)

Elemental Analysis Report (2659 KB)

HNMR (2659 KB)

CNMR (2659 KB)

RP-HPLC (2659 KB)

NP-HPLC (2659 KB)

MS (2659 KB)

LCMS (2659 KB)

IR (2659 KB)

GC (2659 KB)

OR (2659 KB)

SDS-PAGE (2659 KB)

SEC-HPLC (2659 KB)

Other Report (2659 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Han X, et al. Discovery of potent and selective CDK8 inhibitors through FBDD approach. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4488-4492. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg

DMSO 1 mM 3.9185 mL 19.5925 mL 39.1850 mL 97.9624 mL

5 mM 0.7837 mL 3.9185 mL 7.8370 mL 19.5925 mL

10 mM 0.3918 mL 1.9592 mL 3.9185 mL 9.7962 mL

15 mM 0.2612 mL 1.3062 mL 2.6123 mL 6.5308 mL

20 mM 0.1959 mL 0.9796 mL 1.9592 mL 4.8981 mL

25 mM 0.1567 mL 0.7837 mL 1.5674 mL 3.9185 mL

30 mM 0.1306 mL 0.6531 mL 1.3062 mL 3.2654 mL

40 mM 0.0980 mL 0.4898 mL 0.9796 mL 2.4491 mL

50 mM 0.0784 mL 0.3918 mL 0.7837 mL 1.9592 mL

60 mM 0.0653 mL 0.3265 mL 0.6531 mL 1.6327 mL

80 mM 0.0490 mL 0.2449 mL 0.4898 mL 1.2245 mL

100 mM 0.0392 mL 0.1959 mL 0.3918 mL 0.9796 mL

CDK8-IN-1 Related Classifications

HY-103492 Related Classifications

Cell Cycle/DNA Damage

CDK

Disease Areas

Cancer Blood or Cardio-cerebrovascular Disease Urogenital Disease

Breast Cancer Leukemia/Lymphoma/Myeloma Blood Disease Ovarian Cancer Urogenital Cancer

Cancer

Cancer Targeted Therapy Cancer Metabolism and Metastasis

Powered by Bioz See more details on Bioz

Keywords

CDK8-IN-1
1629633-48-2
CDK
Inhibitor
inhibitor
inhibit

Your Recently Viewed Products

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.9185 mL	19.5925 mL	39.1850 mL	97.9624 mL
5 mM	0.7837 mL	3.9185 mL	7.8370 mL	19.5925 mL
10 mM	0.3918 mL	1.9592 mL	3.9185 mL	9.7962 mL
15 mM	0.2612 mL	1.3062 mL	2.6123 mL	6.5308 mL
20 mM	0.1959 mL	0.9796 mL	1.9592 mL	4.8981 mL
25 mM	0.1567 mL	0.7837 mL	1.5674 mL	3.9185 mL
30 mM	0.1306 mL	0.6531 mL	1.3062 mL	3.2654 mL
40 mM	0.0980 mL	0.4898 mL	0.9796 mL	2.4491 mL
50 mM	0.0784 mL	0.3918 mL	0.7837 mL	1.9592 mL
60 mM	0.0653 mL	0.3265 mL	0.6531 mL	1.6327 mL
80 mM	0.0490 mL	0.2449 mL	0.4898 mL	1.2245 mL
100 mM	0.0392 mL	0.1959 mL	0.3918 mL	0.9796 mL

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Biologische Aktivität

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IC₅₀ & Target

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Chemical Information

Lösungsmittel & Löslichkeit

In Vitro

Protokoll

Reinheit & Dokumentation

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CDK8-IN-1

Cell Cycle/DNA Damage Compound Library

Kinase Inhibitor Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Anti-Breast Cancer Compound Library

Anti-Blood Cancer Compound Library

Cancer Stem Cells Compound Library

Heterocyclic Compound Library

Highly Selective Inhibitors Library

Serine/Threonine Kinase Inhibitor Library

Anti-Hematopathy Compound Library

Anti-Ovarian Cancer Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

High-Efficiency Gene Editing Compound Library

Alle CDK Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Protokoll

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table