Cot-IN-4
Cot-IN-4 (compound 32) is a potent cancer osaka thyroid (COT) kinase inhibitor with an IC50 of 6 nM. Cot-IN-4 inhibits the phosphorylation of ERK (IC50: 60 nM) and inhibits TNFα release (IC50: 60 nM). Cot-IN-4 also inhibits the formation of the pro-inflammatory cytokine IL-1β (IC50: 0.2 μM) in Uric acid (HY-B2130)-stimulated macrophages. Cot-IN-4 can be used for the study of inflammatory diseases.
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- CAS. Nr.: 1984784-10-2
- Formel: C30H28N8O
- Molecular Weight:516.60
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
MAP3K8/COT/Tpl2 |
ERK |
IL-1β |
TNF-α |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| PBMC | IC50 |
0.2 μM
Compound: rac-32
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Antiinflammatory activity in human PBMC assessed as inhibition of uric acid induced-IL-1beta formation stimulated with MSU crystals after 3 hrs in presence of ATP
Antiinflammatory activity in human PBMC assessed as inhibition of uric acid induced-IL-1beta formation stimulated with MSU crystals after 3 hrs in presence of ATP
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[PMID: 27502541] |
Chemical Information
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CAS. Nr. 1984784-10-2
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Molecular Weight 516.60
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Formel C30H28N8O
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SMILES
CC(CN1CCOCC1)NC2=CC=C3C(C=CC(N4C=NC5=C4C6=C(N=C5)C=NC(C7=CC=NC=C7)=C6)=C3)=N2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Cot-IN-4 Related Classifications
HY-178726 Related Classifications
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