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Art. -Nr.: HY-162398

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LQ23

LQ23 is a selective inhibitor for CDC2-like kinase 2 (CLK2) with an IC₅₀ of 1.4 nM. LQ23 exhibits anti-inflammatory activity.

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CAS. Nr.: 2997615-62-8
Formel: C₂₄H₂₄N₄OS
Molecular Weight:416.54

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

LQ23 Chemical Structure

CAS. Nr.: 2997615-62-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

LQ23 is a selective inhibitor for CDC2-like kinase 2 (CLK2) with an IC₅₀ of 1.4 nM. LQ23 exhibits anti-inflammatory activity^[1].

IC₅₀ & Target

IC₅₀: 1.4 nM (CLK2), 2.1 nM (CLK1), 3.2 nM (CLK4), 21.7 nM (DYRK1A), >100 nM (CLK3)

Alle CDK Isoform-spezifische Produkte anzeigen :

In Vitro

LQ23 (10-100 nM) dose-dependently inhibits SR protein phosphorylation in chondrocytes, and thereby regulates the selective cleavage of genes^[1].
LQ23 (10-100 nM) dose-dependently inhibits CHIR99021-stimulated Wnt-signaling in HEK-293T cells with IC₅₀ of 2.9 μM^[1].
LQ23 (30 nM) ameliorates osteoarthritis through promotes the bone mesenchymal stem cells (BMSC) differentation into chondrocytes and suppresses the cartilage degradation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Chondrocytes
Concentration:

10-100 nM
Incubation Time:

1 h
Result:

Reduced phosphorylated SRSF4, SRSF5 and SRSF6.
Reduced levels of β-catenin and c myc.

In Vivo

LQ23 (1.5 μg/ kg, single IA injection) inhibits inflammation, protects cartilage and improves function in the monosodium iodoacetate (MIA)-induced and ACLT-pMMx-induced osteoarthritis in Sprague-Dawley rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

MIA-/ACLT-pMMx-induced osteoarthritis in Sprague-Dawley rats model^[1]
Dosage:

1.5 μg/ kg
Administration:

Single IA injection
Result:

Ameliorated the surface of the articular cartilage and the cell arrangement, reduced the thickness of the synovium, increased the gap between the femur and the tibia.
Reduced the levels of inflammatory cytokines and catabolic enzymes.

Chemical Information

CAS. Nr. 2997615-62-8
Molecular Weight 416.54
Formel C₂₄H₂₄N₄OS
SMILES

N[C@H](COC1=CC(C2=CC=C(C3=C2)NN=C3C#CC4=CSC=C4)=CN=C1)CC(C)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Sun Y, Hu T, Zhang M, Song J, Qin Z, Liu M, Ji J, Li Z, Qiu Z, Bian J. Structure-Guided Discovery of Potent and Selective CLK2 Inhibitors for the Treatment of Knee Osteoarthritis. J Med Chem. 2024 Mar 28;67(6):4603-4623. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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Art. -Nr.:
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LQ23

Alle CDK Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

LQ23 Related Classifications

HY-162398 Related Classifications