PD 124816
PD 124816 is an orally active fluoroquinolone antibiotic. PD 124816 exerts broad-spectrum antibacterial effects by inhibiting DNA gyrase (topoisomerase IV), and it has no cross-resistance with commonly used antibiotics. PD 124816 is effective against both Gram-positive and Gram-negative bacteria (MIC₉₀ ≤ 0.06 μg/mL), and the MIC₉₀ for anaerobic bacteria (Peptostreptococcus fragi) is 1 μg/mL. PD 124816 exhibits complete bactericidal activity in a mouse model of Mycobacterium leprae infection. PD 124816 can be used for studying mixed infections and infections caused by drug-resistant bacteria.
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- CAS. Nr.: 112654-98-5
- Formel: C17H18F2N4O3
- Molecular Weight:364.35
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
Quinolone |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| V79 | IC50 |
15 μg/mL
Compound: 17e
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Clonogenic cytotoxicity against Chinese hamster V-79 cells
Clonogenic cytotoxicity against Chinese hamster V-79 cells
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[PMID: 7473575] |
| V79 | IC50 |
15 μg/mL
Compound: 58
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Mammalian cell cytotoxicity test in chinese hamster V79 cells (clonogenic cytotoxicity)
Mammalian cell cytotoxicity test in chinese hamster V79 cells (clonogenic cytotoxicity)
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[PMID: 1469702] |
Chemical Information
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CAS. Nr. 112654-98-5
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Molecular Weight 364.35
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Formel C17H18F2N4O3
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SMILES
FC1=C(C2=C(C(F)=C1N3CC(CC3)N)N)N(C=C(C2=O)C(O)=O)C4CC4
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Cohen MA, et al. In vitro antibacterial activities of the fluoroquinolones PD 117596, PD 124816, and PD 127391. Diagn Microbiol Infect Dis. 1991 May-Jun;14(3):245-58. [Content Brief]
[2]. Gelber RH, et al. Activities of various quinolone antibiotics against Mycobacterium leprae in infected mice. Antimicrob Agents Chemother. 1992 Nov;36(11):2544-7. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
PD 124816 Related Classifications
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