(+)-Theta-cypermethrin
(+)-Theta-cypermethrin is a stereoisomer of Cypermethrin (HY-B0829) that possesses blood-brain barrier penetration ability and binds to AKT1, SRC, STAT3 and EGFR with high affinity. (+)-Theta-cypermethrin reduces the amplitude of delayed rectifier potassium channel currents, shifts the steady-state activation curve to negative potentials, and shifts the steady-state inactivation curve to negative potentials at higher concentrations. (+)-Theta-cypermethrin induces abnormal electrical activity in rat hippocampal neurons. (+)-Theta-cypermethrin causes chronic respiratory system damage and exhibits neurotoxicity.
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- CAS. Nr.: 65732-07-2
- Formel: C22H19Cl2NO3
- Molecular Weight:416.30
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
(+)-Theta-cypermethrin (10-9-10-7 M; applied via perfusion during electrophysiological recording) inhibits delayed rectifier potassium current (Ik) in rat hippocampal CA3 neurons in vitro in a concentration-dependent manner, reduces Ik amplitude by up to 53.28% at 10-7 M, shifts steady-state activation and inactivation curves toward negative potentials, and reduces the activation curve slope factor at 10-7 M[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 65732-07-2
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Molecular Weight 416.30
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Formel C22H19Cl2NO3
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SMILES
C(O[C@H](C#N)C1=CC(OC2=CC=CC=C2)=CC=C1)(=O)[C@@H]3[C@@H](C=C(Cl)Cl)C3(C)C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Tian YT, et al. Effect of alpha-cypermethrin and theta-cypermethrin on delayed rectifier potassium currents in rat hippocampal neurons. Neurotoxicology. 2009;30(2):269-273. [Content Brief]
[2]. Tian J, et al. Network toxicological mechanism analysis of pyrethroid insecticides-induced chronic respiratory system damage in humans. Ecotoxicol Environ Saf. 2025;303:118828. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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