1. GPCR/G Protein
  2. Angiotensin Receptor
  3. AT2 receptor agonist C21

AT2 receptor agonist C21 

Cat. No.: HY-100113
Handling Instructions

AT2 receptor agonist C21 is a druglike selective angiotensin II AT2 receptor agonist with Ki values of 0.4 nM and >10 µM for the AT2 receptor and AT1 receptor, respectively.

For research use only. We do not sell to patients.

AT2 receptor agonist C21 Chemical Structure

AT2 receptor agonist C21 Chemical Structure

CAS No. : 477775-14-7

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Description

AT2 receptor agonist C21 is a druglike selective angiotensin II AT2 receptor agonist with Ki values of 0.4 nM and >10 µM for the AT2 receptor and AT1 receptor, respectively[1].

IC50 & Target

Ki: 0.4 nM (AT2) and >10 µM (AT1)[1]

In Vivo

AT2 receptor agonist C21, with a bioavailability of 20-30% after oral administration and a half-life estimated to 4 h in rat, induces outgrowth of neurite cells, stimulates p42/p44mapk, enhances in vivo duodenal alkaline secretion in Sprague-Dawley rats, and lowers the mean arterial blood pressure in anesthetized, spontaneously hypertensive rats[1].

Molecular Weight

475.62

Formula

C₂₃H₂₉N₃O₄S₂

CAS No.

477775-14-7

SMILES

O=C(OCCCC)NS(=O)(C1=C(C2=CC=C(CN3C=CN=C3)C=C2)C=C(CC(C)C)S1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

AT2 receptor agonist C21Angiotensin ReceptorInhibitorinhibitorinhibit

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AT2 receptor agonist C21
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HY-100113
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