1. GPCR/G Protein
  2. Angiotensin Receptor
  3. AT2 receptor agonist C21

AT2 receptor agonist C21 

Cat. No.: HY-100113 Purity: 98.34%
Handling Instructions

AT2 receptor agonist C21 is a druglike selective angiotensin II AT2 receptor agonist with Ki values of 0.4 nM and >10 µM for the AT2 receptor and AT1 receptor, respectively.

For research use only. We do not sell to patients.

AT2 receptor agonist C21 Chemical Structure

AT2 receptor agonist C21 Chemical Structure

CAS No. : 477775-14-7

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 126 In-stock
Estimated Time of Arrival: December 31
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 190 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

AT2 receptor agonist C21 is a druglike selective angiotensin II AT2 receptor agonist with Ki values of 0.4 nM and >10 µM for the AT2 receptor and AT1 receptor, respectively[1].

IC50 & Target

Ki: 0.4 nM (AT2) and >10 µM (AT1)[1]

In Vivo

AT2 receptor agonist C21, with a bioavailability of 20-30% after oral administration and a half-life estimated to 4 h in rat, induces outgrowth of neurite cells, stimulates p42/p44mapk, enhances in vivo duodenal alkaline secretion in Sprague-Dawley rats, and lowers the mean arterial blood pressure in anesthetized, spontaneously hypertensive rats[1].

Molecular Weight

475.62

Formula

C₂₃H₂₉N₃O₄S₂

CAS No.

477775-14-7

SMILES

O=C(OCCCC)NS(=O)(C1=C(C2=CC=C(CN3C=CN=C3)C=C2)C=C(CC(C)C)S1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (10.51 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1025 mL 10.5126 mL 21.0252 mL
5 mM 0.4205 mL 2.1025 mL 4.2050 mL
10 mM 0.2103 mL 1.0513 mL 2.1025 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

AT2 receptor agonist C21Angiotensin ReceptorInhibitorinhibitorinhibit

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Product Name:
AT2 receptor agonist C21
Cat. No.:
HY-100113
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