Cat. No.: HY-N0889

Ginkgetin

13 Cited Publications

Customer Review

Based on 13 publication(s) in Google Scholar

Ginkgetin, a biflavone, is isolated from Ginkgo biloba leaves. Ginkgetin exhibit anti-tumor, anti-inflammatory, neuroprotective, anti-fungal activities. Ginkgetin is also a potent inhibitor of Wnt signaling, with an IC₅₀ of 5.92 μΜ.

For research use only. We do not sell to patients.

Purity: 99.87%
CAS No.: 481-46-9
Formula: C₃₂H₂₂O₁₀
Molecular Weight:566.51

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Ginkgetin Chemical Structure

CAS No.: 481-46-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (13)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All COX Isoforms :

All Wnt Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
OVCAR-3	IC₅₀	1.8 μg/mL Compound: 1	Growth inhibition of human OVCAR-3 cells after 48 hrs Growth inhibition of human OVCAR-3 cells after 48 hrs	[PMID: 9134745]

In Vitro

Ginkgetin (2.5-20 μM; 48 h) inhibits the growth of Daoy and D283 cell lines, and induces G₂/M cell cycle arrest in Daoy cells^[2].
Ginkgetin (20-40 μM; 24 h) significantly activates the apoptosis of osteosarcoma cells in a concentration-dependent manner^[3].
Ginkgetin (10-20 μM; 3-24 h) down-regulated the expression of Wnt target genes without affecting the expression of β-catenin in medulloblastoma cells^[2].
Ginkgetin (1-10 μM; 24 or 48 h) significantly inhibits the VEGF-induced endothelial cell proliferation, migration, and wound recovery in a concentration-dependent manner^[1].
Ginkgetin (5-10 μM; 48 h) induces autophagy responsible for cell death in A549^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

Daoy and D283 cell lines
Concentration:

2.5, 5, 10, 20 μM
Incubation Time:

48 hours
Result:

Inhibited the cell growth, with IC₅₀s of 14.65 and 15.81 μM for Daoy and D283 cells, respectively.

Apoptosis Analysis^[3]

Cell Line:

Osteosarcoma cells
Concentration:

20, 30, 40 μM
Incubation Time:

24 hours
Result:

Markedly induced the apoptosis of osteosarcoma cells in a concentration-dependent manner.

Cell Cycle Analysis^[2]

Cell Line:

Daoy cells
Concentration:

2.5, 5, 10, 20 μM
Incubation Time:

24 hours
Result:

Increased G₂/M phase, compared with that of control, indicating a G₂/M cell phase arrest.

Cell Cycle Analysis^[2]

Cell Line:

Daoy and D283 cell lines
Concentration:

10, 20 μM
Incubation Time:

3, 6, 12, 24 hours
Result:

Attenuated the expression of Wnt target genes, Axin2, cyclin D1 and survivin at 20 μM for 24 h in Daoy cells.
Unaffected the level of total β-catenin and diminished the level of β-catenin phosphorylation in a time- and concentration-dependent manner.

In Vivo

Ginkgetin (25-100 mg/kg; i.p. 2 hours after the onset of ischemia) exerts anti-inflammatory effects on cerebral ischemia/reperfusion-induced injury in a rat model via the TLR4/NF-κB signaling pathway^[4].
Ginkgetin (30 mg/kg; intragastrically once per day for 42 d) suppresses tumor growth in A549 cells bearing nude mice^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Sprague-Dawley rats (200-220 g)^[4]
Dosage:

25, 50, 100 mg/kg
Administration:

I.p. 2 hours after the onset of ischemia
Result:

Reduced the neurological deﬁcit score.
Suppressed the expression of NF-κB, TLR4 and IκBαin ischemic penumbra cortex, and inhibited the degradation of IκBα.
Decreased the expressions of ICAM-1, COX-2, and iNOS.
Downregulated downstream inﬂammatory factor PGE2 and TNF-α expression.
Decreased IL-1β, IL-6, IL-8, and IL-10 protein expression.

Chemical Information

CAS No. 481-46-9
Appearance Solid
Molecular Weight 566.51
Formula C₃₂H₂₂O₁₀
Color Light yellow to yellow
SMILES

OC1=CC(O)=C2C(OC(C3=CC=C(O)C=C3)=CC2=O)=C1C4=CC(C(OC5=CC(OC)=CC(O)=C56)=CC6=O)=CC=C4OC
Structure Classification
- Flavonoids
- Biflavones
- Phenols
- Polyphenols
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (13)

All RT-PCRCell Imaging/StainingHistological Imaging/StainingIn Vivo Efficacy Study

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Journal Impact Factor

Acta Pharm Sin B

Chrysin serves as a novel inhibitor of DGK α/FAK interaction to suppress the malignancy of esophageal squamous cell carcinoma (ESCC). [Abstract]

2021 Jan;11(1):143-155. PMID: 33532186
Adv Sci (Weinh)

Ginkgetin Alleviates Inflammation and Senescence by Targeting STING. [Abstract]

2025 Jan;12(2):e2407222. PMID: 39558862

Ginkgetin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jan;12(2):e2407222. [Abstract]

Ginkgetin (2 µM; 48 h) downregulated the expression of CDKis, including p16 and p21, as well as SASP-related genes such as Il6 and Il1b in MEFs.

Ginkgetin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jan;12(2):e2407222. [Abstract]

Ginkgetin (2 µM; 48 h) decreased the number of SA-β-gal positive cells among MEFs.

Ginkgetin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jan;12(2):e2407222. [Abstract]

(5 mg/kg; i.p.; once every 2 days for 2 months) reduced the aggregation of immune cells in the kidney and liver of C57BL/6J mice injected with Dox.

Ginkgetin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jan;12(2):e2407222. [Abstract]

Ginkgetin (5 mg/kg; i.p.; once every 2 days for 2 months) diminished the accumulation of SA‐β‐Gal positive senescent cells in the kidney of C57BL/6J mice injected with Dox.

Ginkgetin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jan;12(2):e2407222. [Abstract]

Ginkgetin (5 mg/kg; i.p.; once every 2 days for 2 months) efficiently alleviated physical dysfunction of C57BL/6J mice injected with Dox.
Food Chem

Effects of sun drying combined with baking processes on the flavor quality of Chongqing Tuocha raw tea. [Abstract]

2025 Dec 30:497:146992. PMID: 41285060
Food Chem

Flavonoid-mediated metabolic underpinning quality variation in red bud-sport pear mutants. [Abstract]

2025 Oct 15:489:144992. PMID: 40466530
Free Radic Biol Med

TFEB-nuclear translocation promotes BNIP3-mediated mitophagy and alleviates oxidative stress and ferroptosis in acute pancreatitis. [Abstract]

2025 Nov 23:243:398-413. PMID: 41290101
Biochem Pharmacol

Ginkgetin alleviates cisplatin-induced muscle atrophy via inhibition of the macrophage cGAS-STING pathway. [Abstract]

2026 Mar 8:249:117879. PMID: 41806931
Naunyn Schmiedebergs Arch Pharmacol

Ginkgetin inhibits non-small cell lung cancer via the HSP90-AKT signaling pathway. [Abstract]

2026 Feb 11. PMID: 41670694
Toxicol Appl Pharmacol

Ginkgetin enhances breast cancer radiotherapy sensitization by suppressing NRF2-HO-1 axis activity. [Abstract]

2024 Dec 7:495:117199. PMID: 39653086
Mol Biol Rep

Ginkgetin inhibits the proliferation and migration of lung cancer cells via FAK/STAT3/AKT pathway. [Abstract]

2025 May 14;52(1):458. PMID: 40366441
Biomed Res Int

Exploring the Antitumor Mechanisms of Zingiberis Rhizoma Combined with Coptidis Rhizoma Using a Network Pharmacology Approach. [Abstract]

2020 Dec 24:2020:8887982. PMID: 33426081
Biomed Res Int

Ginkgetin Alleviates Inflammation, Oxidative Stress, and Apoptosis Induced by Hypoxia/Reoxygenation in H9C2 Cells via Caspase-3 Dependent Pathway. [Abstract]

2020 Nov 4:2020:1928410. PMID: 33204684
Immunol Invest

Ginkgetin Alleviates Intervertebral Disc Degeneration by Inhibiting Apoptosis, Inflammation, and Disturbance of Extracellular Matrix Synthesis and Catabolism via Inactivation of NLRP3 Inflammasome. [Abstract]

2023 Nov;52(5):546-560. PMID: 37154418
SSRN

2025 Jan 10.

Solvent & Solubility

In Vitro:

DMSO : ≥ 20.83 mg/mL (36.77 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.7652 mL

8.8260 mL

17.6519 mL

5 mM

0.3530 mL

1.7652 mL

3.5304 mL

10 mM

0.1765 mL

0.8826 mL

1.7652 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

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In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 50% PEG300 50% Saline

Solubility: 2 mg/mL (3.53 mM); Suspended solution; Need ultrasonic and warming

Protocol 2

Add each solvent one by one: 0.5% CMC-Na/saline water

Solubility: 2 mg/mL (3.53 mM); Suspended solution; Need ultrasonic and warming and heat to 60°C

Protocol 3

Add each solvent one by one: 0.5% CMC-Na/0.5% Tween-80 in Saline water

Solubility: 3 mg/mL (5.30 mM); Suspended solution; Need ultrasonic and warming and heat to 60°C

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (282 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hu WH, et, al. Synergy of Ginkgetin and Resveratrol in Suppressing VEGF-Induced Angiogenesis: A Therapy in Treating Colorectal Cancer. Cancers (Basel). 2019 Nov 20;11(12):1828. [Content Brief]

[2]. Ye ZN, et, al. Biflavone Ginkgetin, a Novel Wnt Inhibitor, Suppresses the Growth of Medulloblastoma. Nat Prod Bioprospect. 2015 Mar 29;5(2):91-97. [Content Brief]

[3]. Xiong M, et, al. Ginkgetin exerts growth inhibitory and apoptotic effects on osteosarcoma cells through inhibition of STAT3 and activation of caspase-3/9. Oncol Rep. 2016 Feb;35(2):1034-40. [Content Brief]

[4]. Li Q, et, al. Ginkgetin exerts anti-inflammatory effects on cerebral ischemia/reperfusion-induced injury in a rat model via the TLR4/NF-κB signaling pathway. Biosci Biotechnol Biochem. 2019 Apr;83(4):675-683. [Content Brief]

[5]. Lou J, et, al. Ginkgetin induces autophagic cell death through p62/SQSTM1-mediated autolysosome formation and redox setting in non-small cell lung cancer. Oncotarget. 2017 Oct 16;8(54):93131-93148. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.7652 mL	8.8260 mL	17.6519 mL	44.1298 mL
	5 mM	0.3530 mL	1.7652 mL	3.5304 mL	8.8260 mL
	10 mM	0.1765 mL	0.8826 mL	1.7652 mL	4.4130 mL
	15 mM	0.1177 mL	0.5884 mL	1.1768 mL	2.9420 mL
	20 mM	0.0883 mL	0.4413 mL	0.8826 mL	2.2065 mL
	25 mM	0.0706 mL	0.3530 mL	0.7061 mL	1.7652 mL
	30 mM	0.0588 mL	0.2942 mL	0.5884 mL	1.4710 mL

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Ginkgetin

Apoptosis Compound Library

Immunology/Inflammation Compound Library

Stem Cell Signaling Compound Library

Wnt/Hedgehog/Notch Compound Library

Natural Product Library

Anti-Cancer Compound Library

Autophagy Compound Library

Anti-Aging Compound Library

Differentiation Inducing Compound Library

Medicine Food Homology Compound Library

Phenols Library

Cytoskeleton Compound Library

Orally Active Compound Library

Traditional Chinese Medicine Active Compound Library

Flavonoids Library

Neuroprotective Compound Library

Anti-Breast Cancer Compound Library

Food-Sourced Compound Library

Anti-Liver Cancer Compound Library

Anti-Colorectal Cancer Compound Library

Anti-Cancer Natural Product Library

Anti-inflammatory Traditional Chinese Medicine Active Compound Library

Plant-Sourced Natural Product Library

Human Metabolite Library

Anti-Prostate Cancer Compound Library

Anti-Pulmonary Fibrosis Compound Library

Cancer Stem Cells Compound Library

Antihypertensive Compound Library

Highly Selective Inhibitors Library

Highly Selective Activators Library

Cell Death Library

Extracellular Vesicles (EVs) Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Anti-Gastric Cancer Compound Library

Anti-Fibrosis Compound Library

Miao Ethnicity Medicine Compound Library

PBCRBS Traditional Chinese Medicine Compound Library

Heat-Clearing and Detoxification Traditional Chinese Medicine Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

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Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library

Anti-Rheumatic Arthritis Compound Library

Mass Spectrometry Human Metabolite Library

Antitussive and Antiasthmatic Traditional Chinese Medicine Active Compound Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Mongolian Medicine Compound Library

Tonifying Traditional Chinese Medicine Monomer Compound Library

Mass Spectrometry Natural Product Library

Publications Citing Use of MedChemExpress (MCE) Ginkgetin

All COX Isoforms

All Wnt Isoforms

Biological Activity

Chemical Information

Publications (13)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Ginkgetin Related Classifications

HY-N0889 Related Classifications