Sequoiaflavone
Sequoiaflavone is a biflavonoid compound with multiple activities. Sequoiaflavone suppresses hepatic CYP1A1/(7-Ethoxycoumarin O-deethylase) ECOD, prevents Aβ1-42 fibrillization (IC50 = 0.29 μM) and disaggregates amyloid fibrils (EC50 = 2.04 μM), inhibits Alternaria alternata and inhibits human recombinant PDE5A1 overexpressed in COS-7 cells (IC50 = 19.9 μM) to exert NO-independent vasodilation. Sequoiaflavone can be used in Alzheimer's disease, peripheral circulatory disorder, and antifungal research.
For research use only. We do not sell to patients.
- CAS No.: 21763-71-3
- Formula: C31H20O10
- Molecular Weight:552.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
58.4 μM
Compound: 6
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Cytotoxicity against human MCF7 cells measured after 24 hrs by MTT assay
Cytotoxicity against human MCF7 cells measured after 24 hrs by MTT assay
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[PMID: 34875389] |
| PC-3 | GI50 |
43.29 μM
Compound: 18
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Growth inhibition of human PC3 cells by colorimetric MTT assay
Growth inhibition of human PC3 cells by colorimetric MTT assay
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[PMID: 25736997] |
Sequoiaflavone (100 μM; 4 h) fully inhibits spore germination of Alternaria alternata with an ED50 of 18 μM[1].
Sequoiaflavone (100 μM; 7 h) exerts obvious inhibitory effects on germ tube growth of Fusarium culmorum with an ED50 of 12 μM[1].
Sequoiaflavone (100 μM; 24 h) shows no detectable antifungal activity against Cladosporium oxysporum [1].
Sequoiaflavone (0.08 mg/mL) potently inhibits ECOD activity by 75.2%, leaving just 24.8% residual enzyme activity versus the 100% control level in rat liver microsomes[2].
Sequoiaflavone inhibits formation of Aβ fibrils with an IC50 of 0.29 μM[3].
Sequoiaflavone inhibits human recombinant PDE5A1 with an IC50 of 19.9 μM in COS-7 cells[4].
Sequoiaflavone blocks PDE5A1 activity to slow cGMP degradation in COS-7 cells[4].
Sequoiaflavone produces vasodilation via a NO-independent pathway in COS-7 cells[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 21763-71-3
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Molecular Weight 552.48
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Formula C31H20O10
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SMILES
O=C1C=C(C2=CC=C(O)C=C2)OC3=C(C4=CC(C5=CC(C6=C(O)C=C(OC)C=C6O5)=O)=CC=C4O)C(O)=CC(O)=C13
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Krauze-Baranowska M, et al. Antifungal activity of biflavones from Taxus baccata and Ginkgo biloba. Z Naturforsch C J Biosci. 2003 Jan-Feb;58(1-2):65-9. [Content Brief]
[2]. Fidelis QC, et al. Flavonoids and other compounds from Ouratea ferruginea (Ochnaceae) as anticancer and chemopreventive agents. Molecules. 2012 Jul 3;17(7):7989-8000. [Content Brief]
[3]. Choi EY, et al. Polyphenolic Biflavonoids Inhibit Amyloid-Beta Fibrillation and Disaggregate Preformed Amyloid-Beta Fibrils. Biomol Ther (Seoul). 2020 Mar 1;28(2):145-151. [Content Brief]
[4]. Dell'Agli M, et al. Inhibition of cGMP-phosphodiesterase-5 by biflavones of Ginkgo biloba. Planta Med. 2006 Apr;72(5):468-70. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sequoiaflavone Related Classifications
HY-119416 Related Classifications
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