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Cat. No.: HY-114894

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2C07

2C07 is a mutant Ras (K-Ras^M72C, H-Ras^M72C) inhibitor. 2C07 blocks the activation of PI3K through allosteric Ras modification. 2C07 binds to the modified switch II pocket (S-IIG) of Ras in both GDP- and GTP-bound states, stabilizes the GDP-bound state, disrupts the polar interactions of the canonical GTP-bound state, and inhibits SOS binding and nucleotide exchange. 2C07 can be used in cancer-related research.

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CAS No.: 2230185-95-0
Formule: C₁₉H₂₅F₃N₄O₂S₂
Masse moléculaire:462.55

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Please store the product under the recommended conditions in the Certificate of Analysis.

2C07 Chemical Structure

CAS No.: 2230185-95-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
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Activité biologique

Description

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In Vitro

2C07 selectively binds to the engineered Cys72 residue in truncated K-Ras^M72C GDP and truncated H-Ras^M72C GppNHp with βME₅₀ values of 2.53 mM and 1.10 mM, respectively, and does not modify wild-type Ras constructs^[1].
2C07 binds to the switch-II groove (S-IIG) of truncated K-Ras^M72C GDP and truncated H-Ras^M72C in both GDP and GppNHp states, inducing a modified switch-II pocket conformation and, in the GppNHp state, altering switch I positioning and Mg²⁺ coordination^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2230185-95-0
Masse moléculaire 462.55
Formule C₁₉H₂₅F₃N₄O₂S₂
SMILES

O=C(NCCCSSCCN(C)C)C1=C(N(N=C1)C2=CC=C(C=C2)OC)C(F)(F)F
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Gentile DR, et al. Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States. Cell chemical biology. 2017 Dec 21;24(12):1455-1466.e14. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
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- In Vitro
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Pureté et documentation
Références

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2C07

Voir tous les produits spécifiques à Isoform Ras

Voir tous les produits spécifiques à Isoform PI3K