Cat. No.: HY-N7108

7-Hydroxyflavone

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7-Hydroxyflavone is a flavonoid isolated from Clerodendrum phlomidis, with anti-inflammatory activity. 7-Hydroxyflavone protects renal cells from nicotine (NIC)-associated cytotoxicity via the ERK/Nrf2/HO-1 pathway. 7-Hydroxyflavone inhibits PKM2 with an IC₅₀ of 2.12 μM. 7-Hydroxyflavone inhibits COX-2 and 5-LOX with IC₅₀ of 27 µg/mL and 33 µg/mL. 7-Hydroxyflavone is orally active.

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Pureté: 99.89%
CAS No.: 6665-86-7
Formule: C₁₅H₁₀O₃
Masse moléculaire:238.24

Stockage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

7-Hydroxyflavone Chemical Structure

CAS No.: 6665-86-7

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Activité biologique
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
Références
Help & FAQs
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Activité biologique

Description

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Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	EC₅₀	>50 μM Compound: 7-Hydroxyflavone	Cytotoxicity against human HCT116 cells assessed as cell viability after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 26529431]
HEK293	IC₅₀	>20 μM Compound: 15	Inhibition of human recombinant 17beta-HSD2 expressed in HEK293 cell lysate assessed as conversion of radiolabeled estrone to estradiol Inhibition of human recombinant 17beta-HSD2 expressed in HEK293 cell lysate assessed as conversion of radiolabeled estrone to estradiol	[PMID: 18533708]
HEK293	IC₅₀	5.25 μM Compound: 15	Inhibition of human recombinant 17beta-HSD1 expressed in HEK293 cell lysate assessed as conversion of radiolabeled estrone to estradiol Inhibition of human recombinant 17beta-HSD1 expressed in HEK293 cell lysate assessed as conversion of radiolabeled estrone to estradiol	[PMID: 18533708]
Neutrophil	IC₅₀	33 μM Compound: 3a	Inhibition of oxidative burst in PMA-stimulated human neutrophils assessed as inhibition of superoxide anion radical-induced lucigenin oxidation incubated for 5 mins prior to PMA challenge by chemiluminescence assay Inhibition of oxidative burst in PMA-stimulated human neutrophils assessed as inhibition of superoxide anion radical-induced lucigenin oxidation incubated for 5 mins prior to PMA challenge by chemiluminescence assay	[PMID: 23871908]

In Vitro

7-Hydroxyflavone (20 μM, 24 h) inhibits nicotine-induced cytotoxicity, reduces nicotine-induced ROS production, and exhibits antioxidant activity in rat renal proximal tubule cells NRK52E^[2].
7-Hydroxyflavone (50 μM, 24 h) inhibits EV71 3C protease, blocks the viral replication, and inhibits the proliferation of enterovirus 71 (EV71) with an EC₅₀ of 19.95 μM^[3].
7-Hydroxyflavone (50 μM, 24 h) decreases malondialdehyde (MDA) and ROS levels, increases SOD and GSH levels, increases mitochondrial DNA content and ATP levels in HepG2 cells^[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence^[7]

Cell Line:

HepG2
Concentration:

50 μM
Incubation Time:

24 h
Result:

Reduced the ROS level.

In Vivo

7-Hydroxyflavone (5-20 mg/kg, ip, once a day for 7 days) inhibits inflammatory cytokines, reduces myocardial injury markers (such as c-TnI, CK, LDH, and AST), inhibits apoptosis, alleviates oxidative stress, and ameliorates ischemia/reperfusion injury in rats models through MAPK/NF-κB signaling pathway^[5].
7-Hydroxyflavone (5-20 mg/kg, ip, once a day for 7-10 days) ameliorates Paclitaxel (HY-B0015) or Vinorelbine (HY-12053)-induced neuropathic pain in mice model^[6].
7-Hydroxyflavone (50-100 mg/kg, po, once a day for 15 weeks) reduces fat accumulation, improves hepatic steatosis and oxidative stress, regulates blood glucose metabolism, and promotes energy metabolism in mouse NAFLD models^[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Ischemia/reperfusion injury Sprague Dawley rat model^[5]
Dosage:

5-20 mg/kg
Administration:

ip, once a day for 7 days
Result:

Improved the cardiac functions, reduced the myocardial infarct size.

Animal Model:

Paclitaxel (HY-B0015) or Vinorelbine (HY-12053)-induced hyperalgesia in mice model^[6]
Dosage:

5-20 mg/kg
Administration:

ip, once a day for 7-10 days
Result:

Ameliorated neuropathic pain.

Animal Model:

C57BL/6 mouse NAFLD models^[7]
Dosage:

50-100 mg/kg
Administration:

po, once a day for 15 weeks
Result:

Improved high-fat diet-induced non-alcoholic fatty liver disease and improved obesity, oxidative stress, glucose metabolism disorders, and energy metabolism.

Chemical Information

CAS No. 6665-86-7
Appearance Solid
Masse moléculaire 238.24
Formule C₁₅H₁₀O₃
Color White to off-white
SMILES

O=C1C=C(C2=CC=CC=C2)OC3=CC(O)=CC=C13
Structure Classification
- Flavonoids
- Flavones
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Journal Impact Factor

Biochem Pharmacol

Chemoproteomics-based profiling reveals the targeting molecular mechanism of reversal of cisplatin resistance by baicalin in head and neck squamous cell carcinoma. [Abstract]

2025 Sep 21;242(Pt 3):117360. PMID: 40987408

Solvant et solubilité

In Vitro:

DMSO : 125 mg/mL (524.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.1974 mL

20.9872 mL

41.9745 mL

5 mM

0.8395 mL

4.1974 mL

8.3949 mL

10 mM

0.4197 mL

2.0987 mL

4.1974 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (8.73 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: 2.08 mg/mL (8.73 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.08 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (8.73 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (278 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Vinutha K, et al. Aqueous extract from Madhuca indica bark protects cells from oxidative stress caused by electron beam radiation: in vitro, in vivo and in silico approach. Heliyon. 2019 May 30;5(5):e01749. [Content Brief]

[2]. Sengupta B, et al. Differential roles of 3-Hydroxyflavone and 7-Hydroxyflavone against nicotine-induced oxidative stress in rat renal proximal tubule cells. PLoS One. 2017 Jun 22;12(6):e0179777. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.1974 mL	20.9872 mL	41.9745 mL	104.9362 mL
	5 mM	0.8395 mL	4.1974 mL	8.3949 mL	20.9872 mL
	10 mM	0.4197 mL	2.0987 mL	4.1974 mL	10.4936 mL
	15 mM	0.2798 mL	1.3991 mL	2.7983 mL	6.9957 mL
	20 mM	0.2099 mL	1.0494 mL	2.0987 mL	5.2468 mL
	25 mM	0.1679 mL	0.8395 mL	1.6790 mL	4.1974 mL
	30 mM	0.1399 mL	0.6996 mL	1.3991 mL	3.4979 mL
	40 mM	0.1049 mL	0.5247 mL	1.0494 mL	2.6234 mL
	50 mM	0.0839 mL	0.4197 mL	0.8395 mL	2.0987 mL
	60 mM	0.0700 mL	0.3498 mL	0.6996 mL	1.7489 mL
	80 mM	0.0525 mL	0.2623 mL	0.5247 mL	1.3117 mL
	100 mM	0.0420 mL	0.2099 mL	0.4197 mL	1.0494 mL

Keywords

7-Hydroxyflavone

1 Cited Publications

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7-Hydroxyflavone

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Publications Citing Use of MedChemExpress (MCE) 7-Hydroxyflavone

Voir tous les produits spécifiques à Isoform ERK

Voir tous les produits spécifiques à Isoform COX

Voir tous les produits spécifiques à Isoform Lipoxygenase

Activité biologique

Chemical Information

Publications (1)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

7-Hydroxyflavone Related Classifications

Cat. No.: HY-N7108