Clopidol
Based on 1 Customer Validation
Clopidol (WR-61112) is an anticoccidial agent which is used as feed additive to control coccidiosis in chickens. Clopidol inhibits the sporulation of Eimeria tenella oocysts.
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- Pureté: 99.78%
- CAS No.: 2971-90-6
- Formule: C7H7Cl2NO
- Masse moléculaire:192.04
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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Plasmodium |
Coccidia |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | IC50 |
1.46 μM
Compound: 3
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Antiplasmodial activity against liver stage Plasmodium berghei infected in human HuH7 cells co-expressing GFP-Luccon treated for 1 hr prior to infection followed by 24 hrs after compound washout measured after 48 hrs post-infection by Alamar Blue assay
Antiplasmodial activity against liver stage Plasmodium berghei infected in human HuH7 cells co-expressing GFP-Luccon treated for 1 hr prior to infection followed by 24 hrs after compound washout measured after 48 hrs post-infection by Alamar Blue assay
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[PMID: 23701465] |
Clopidol is active against Plasmodium falciparum W2 (chloroquine-resistant) and FCR3 (atovaquone-resistant) strains in the low micromolar range[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2971-90-6
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Appearance Solid
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Masse moléculaire 192.04
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Formule C7H7Cl2NO
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Color White to off-white
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SMILES
OC1=C(Cl)C(C)=NC(C)=C1Cl
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Synonyms
WR-61112
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvant et solubilité
0.1 M NaOH : 26 mg/mL (135.39 mM; ultrasonic and adjust pH to 3 with NaOH)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (275 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Pang GF, et, al. Determination of clopidol residues in chicken tissues by high-performance liquid chromatography-mass spectrometry. J Chromatogr A. 2000 Jun 16;882(1-2):85-8. [Content Brief]
[2]. Arakawa A, et, al. Effects of clopidol on sporulation and infectivity of Eimeria tenella oocysts. Vet Parasitol. 1991 Jan;38(1):55-60. [Content Brief]
[3]. Rodrigues T, et, al. Design, synthesis and structure-activity relationships of (1H-pyridin-4-ylidene)amines as potential antimalarials. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3476-80. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| 0.1 M NaOH | 1 mM | 5.2072 mL | 26.0362 mL | 52.0725 mL | 130.1812 mL |
| 5 mM | 1.0414 mL | 5.2072 mL | 10.4145 mL | 26.0362 mL | |
| 10 mM | 0.5207 mL | 2.6036 mL | 5.2072 mL | 13.0181 mL | |
| 15 mM | 0.3471 mL | 1.7357 mL | 3.4715 mL | 8.6787 mL | |
| 20 mM | 0.2604 mL | 1.3018 mL | 2.6036 mL | 6.5091 mL | |
| 25 mM | 0.2083 mL | 1.0414 mL | 2.0829 mL | 5.2072 mL | |
| 30 mM | 0.1736 mL | 0.8679 mL | 1.7357 mL | 4.3394 mL | |
| 40 mM | 0.1302 mL | 0.6509 mL | 1.3018 mL | 3.2545 mL | |
| 50 mM | 0.1041 mL | 0.5207 mL | 1.0414 mL | 2.6036 mL | |
| 60 mM | 0.0868 mL | 0.4339 mL | 0.8679 mL | 2.1697 mL | |
| 80 mM | 0.0651 mL | 0.3255 mL | 0.6509 mL | 1.6273 mL | |
| 100 mM | 0.0521 mL | 0.2604 mL | 0.5207 mL | 1.3018 mL |
Clopidol Related Classifications
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