Acyclovir hydrochloride
Based on 29 publication(s) in Google Scholar
Acyclovir (Aciclovir) hydrochloride is a potent, orally active antiviral agent. Acyclovir hydrochloride has antiherpetic activity with IC50 values of 0.85 μM and 0.86 μM for HSV-1 and HSV-2, respectively. Acyclovir hydrochloride induces cell cycle perturbation and apoptosis. Acyclovir hydrochloride prevents bacterial infections during induction therapy for acute leukaemia.
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- CAS No.: 1628039-62-2
- Formule: C8H12ClN5O3
- Masse moléculaire:261.67
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) Acyclovir hydrochloride
More- Signal Transduct Target Ther. 2025 Dec 15;10(1):406. [Abstract]
- Mol Cell. 2026 Feb 19;86(4):722-739.e8. [Abstract]
- Sci Adv. 2025 Nov 21;11(47):eadw4206. [Abstract]
- Phytomedicine. 2026 Feb:151:157802. [Abstract]
- Phytomedicine. 2024 Nov:134:156015. [Abstract]
- Acta Pharmacol Sin. 2024 Nov;45(11):2380-2393. [Abstract]
- EMBO J. 2025 Apr;44(7):2157-2182. [Abstract]
- Cell Rep. 2026 Mar 12;45(3):117099. [Abstract]
- Emerg Microbes Infect. 2026 Dec;15(1):2717859.
- Eur J Med Chem. 2023 Mar 15:250:115184. [Abstract]
- Ocul Surf. 2026 Jul 16:42:129-143.
- Drug Des Devel Ther. 2022 Dec 20:16:4311-4323. [Abstract]
- Front Microbiol. 2021 Jun 18:12:691008. [Abstract]
- Microchem J. 2021, 106587.
- Mol Med Rep. 2025 Jul;32(1):203. [Abstract]
- Antiviral Res. 2024 Aug:228:105936. [Abstract]
- Antiviral Res. 2024 Jan:221:105787. [Abstract]
- Virol J. 2025 Jul 19;22(1):249. [Abstract]
- Microb Pathog. 2026 Apr:213:108349. [Abstract]
- J Med Virol. 2023 Jan;95(1):e28226. [Abstract]
- Virus Res. 2026 Sep 12:199799.
- Front Oncol. 2024 Dec 19:14:1501981. [Abstract]
- Vet Microbiol. 2026 Jun 17:320:111115. [Abstract]
- SSRN. 2026 Aug 21.
- Zoonoses. 2026 Jun 5.
- SSRN. 2026 Jun 24.
- bioRxiv. 2026 May 4.
- University of Auckland. 2025.
- Biomed Pharmacother. 2023 Jun:162:114595. [Abstract]
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Activité biologique
Description
Chemical Information
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CAS No. 1628039-62-2
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Masse moléculaire 261.67
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Formule C8H12ClN5O3
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SMILES
O=C1N=C(NC2=C1N=CN2COCCO)N.Cl
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Synonyms
Aciclovir hydrochloride; Acycloguanosine hydrochloride
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (29)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]2025 Dec 15;10(1):406. PMID: 41392286 -
Mol Cell
Asparagine sensing by TBK1 controls its phase separation to drive antiviral innate immune responses. [Abstract]2026 Feb 19;86(4):722-739.e8. PMID: 41653919 -
Sci Adv
Transition of pseudorabies virus from latency to reactivation state selectively triggered by pathogenic bacteria. [Abstract]2025 Nov 21;11(47):eadw4206. PMID: 41259522
Acyclovir hydrochloride purchased from MedChemExpress. Usage Cited in: Sci Adv. 2025 Nov 21;11(47):eadw4206. [Abstract]
Fluorescence microscopy images depicting N2a cells infected with different doses of HuBXY/2018-mCherry with or without Acyclovir (ACV: 200 μM) and IFN-α treatments. The images were acquired on 8 dpi.
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Phytomedicine
Inhibition of herpes simplex virus infection by Caesappanin C targeting virus gB protein and host HSP90β. [Abstract]2026 Feb:151:157802. PMID: 41544463
Acyclovir hydrochloride purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2026 Feb:151:157802. [Abstract]
The antiviral activity of Acyclovir (ACV) against HSV-1 in different cell cultures was evaluated using the CPE inhibition assay (MOI = 1).
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Phytomedicine
Salvianolic acid A inhibits pseudorabies virus infection by directly inactivating the virus particle. [Abstract]2024 Nov:134:156015. PMID: 39244942 -
Acta Pharmacol Sin
A small molecule compound targeting hemagglutinin inhibits influenza A virus and exhibits broad-spectrum antiviral activity. [Abstract]2024 Nov;45(11):2380-2393. PMID: 38987389
Acyclovir hydrochloride purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2024 Nov;45(11):2380-2393. [Abstract]
Acyclovir (2 μM). The inhibitory effect of J1 on HSV1 (MOI = 0.1) infection in Vero cells was analyzed by plaque assay.
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EMBO J
A novel biosensor for the spatiotemporal analysis of STING activation during innate immune responses to dsDNA. [Abstract]2025 Apr;44(7):2157-2182. PMID: 39984755
Acyclovir hydrochloride purchased from MedChemExpress. Usage Cited in: EMBO J. 2025 Apr;44(7):2157-2182. [Abstract]
HeLa SIRF biosensor cells were analyzed 24 hours after being treated with a simulated method or infected with 0.5 MOI of HSV-1 virus expressing mCherry, with or without Acyclovir (50 µM).
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Cell Rep
Enucleated cells with Nectin-1 overexpression capture HSV-1 and promote viral elimination for herpes simplex encephalitis therapy. [Abstract]2026 Mar 12;45(3):117099. PMID: 41824450 -
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Eur J Med Chem
Design and syntheses of a bimolecular STING agonist based on the covalent STING antagonist. [Abstract]2023 Mar 15:250:115184. PMID: 36758305 -
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Drug Des Devel Ther
2022 Dec 20:16:4311-4323. PMID: 36573068 -
Front Microbiol
In vitro Studies and Clinical Observations Imply a Synergistic Effect Between Epstein-Barr Virus and Dengue Virus Infection. [Abstract]2021 Jun 18:12:691008. PMID: 34220783 -
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Mol Med Rep
Identification of metabolites associated with capecitabine‑induced hand‑foot syndrome using untargeted metabolomics in patients with cancer. [Abstract]2025 Jul;32(1):203. PMID: 40377002 -
Antiviral Res
Flexible nano-liposomes-encapsulated recombinant UL8-siRNA (r/si-UL8) based on bioengineering strategy inhibits herpes simplex virus-1 infection. [Abstract]2024 Aug:228:105936. PMID: 38908520 -
Antiviral Res
Pralatrexate inhibited the replication of varicella zoster virus and vesicular stomatitis virus: An old dog with new tricks. [Abstract]2024 Jan:221:105787. PMID: 38145756 -
Virol J
Small molecule UCM05 inhibits HSV-2 infection via targeting viral glycoproteins and fatty acid synthase with potentiating antiviral immunity. [Abstract]2025 Jul 19;22(1):249. PMID: 40684179 -
Microb Pathog
mTORC2-dependent autophagy inhibition regulates the replication of HSV-1 and adenovirus in viral keratitis & conjunctivitis. [Abstract]2026 Apr:213:108349. PMID: 41628839 -
J Med Virol
Small molecule RAF265 as an antiviral therapy acts against HSV-1 by regulating cytoskeleton rearrangement and cellular translation machinery. [Abstract]2023 Jan;95(1):e28226. PMID: 36251738 -
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Front Oncol
Gut virome dysbiosis impairs antitumor immunity and reduces 5-fluorouracil treatment efficacy for colorectal cancer. [Abstract]2024 Dec 19:14:1501981. PMID: 39791120 -
Vet Microbiol
Pseudorabies virus EP0 recruits TECPR2 and CK2 to promote COPII accumulation and viral egress. [Abstract]2026 Jun 17:320:111115. PMID: 42322707 -
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Biomed Pharmacother
A potential anti-HIV-1 compound, Q308, inhibits HSV-2 infection and replication in vitro and in vivo. [Abstract]2023 Jun:162:114595. PMID: 36989723
Acyclovir hydrochloride purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2023 Jun:162:114595. [Abstract]
Acyclovir (ACV; 2.5 μM; 48 h) significantly inhibits the expression of gD in HSV-2-infected HeLa, Vero, Beas-2B and HaCaT cells.
Pureté et documentation
Références
[1]. Benedetti S, et, al. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells, and enhances chemotherapeutic drug cytotoxicity. Life Sci. 2018 Dec 15;215:80-85. [Content Brief]
[2]. Suzuki M, et, al. Synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus. Antiviral Res. 2006 Nov;72(2):157-61. [Content Brief]
[3]. Li Z, et, al. Acyclovir treatment of skin lesions results in immune deviation in mice infected cutaneously with herpes simplex virus. Antivir Chem Chemother. 1999 Sep;10(5):251-7. [Content Brief]
[4]. Lönnqvist B, et, al. Oral acyclovir as prophylaxis for bacterial infections during induction therapy for acute leukaemia in adults. The Leukemia Group of Middle Sweden. Support Care Cancer. 1993 May;1(3):139-44. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Acyclovir hydrochloride Related Classifications
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