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Cat. No.: HY-180941

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Bfl-1-IN-7

Bfl-1-IN-7 is an orally active and selective Bfl-1 inhibitor with an IC₅₀ value of 0.015 μM. Bfl-1-IN-7 activates caspase 3/7, and when combined with the Mcl-1 inhibitor AZD5991 (HY-101533), it reduces the viability of lymphoma cells. Bfl-1-IN-7 can be used in lymphoma-related studies.

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Formule: C₂₄H₂₆F₃N₃O₃
Masse moléculaire:461.48

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Bfl-1-IN-7 Chemical Structure

Stock

Quantité

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- Parmacokinetics
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

^[1]

Bfl-1

0.015 μM (IC₅₀)

Caspase-3

Caspase-7

Voir tous les produits spécifiques à Isoform Bcl-2 Family :

Voir tous les produits spécifiques à Isoform Caspase :

Cellular Effect

Cell Line	Type	Value	Description	References
SU-DHL-1	EC50	0.31 μM	Induction of caspase activation (a marker of apoptosis) in SU-DHL-1 lymphoma cells when combined with Mcl-1 inhibitor AZD5991, measured after 6-hour incubation. Induction of caspase activation (a marker of apoptosis) in SU-DHL-1 lymphoma cells when combined with Mcl-1 inhibitor AZD5991, measured after 6-hour incubation.	41432228
SU-DHL-1	EC50	0.21 μM	Reduction of SU-DHL-1 lymphoma cell viability measured after 24-hour incubation. Reduction of SU-DHL-1 lymphoma cell viability measured after 24-hour incubation.	41432228
KARPAS-422	EC50	>10 μM	Lack of cell viability reduction in Bfl-1-null Karpas-422 cells, with no effect observed at concentrations up to 10 μM after 24-hour incubation. Lack of cell viability reduction in Bfl-1-null Karpas-422 cells, with no effect observed at concentrations up to 10 μM after 24-hour incubation.	41432228

In Vitro

OthersAnti-cancer

Others

Bfl-1-IN-7 (compound 25) potently and selectively inhibits purified Bfl-1 protein with an IC₅₀ of 0.015 μM. When combined with the Mcl-1 inhibitor AZD5991 (HY-101533), it induces caspase activation in SU-DHL-1 lymphoma cells with an EC₅₀ of 0.31 μM^[1].
Bfl-1-IN-7 (0.2-20 μM; 4 h) covalently labels the C55 residue of Bfl-1 in LY10 lymphoma cells in a dose-dependent and selective manner, with extremely low off-target activity against BTK C481^[1].
Bfl-1-IN-7 potently inhibits Bfl-1 in biochemical FRET assays, with a mean pIC₅₀ of 7.809; in combination with AZD5991, it induces caspase 3/7 activation in SU-DHL-1 cells, with a mean pEC₅₀ of 6.503^[1].
Bfl-1-IN-7 covalently binds to purified Bfl-1 in a concentration- and time-dependent manner, and its observed rate constant increases with the elevation of compound concentration^[1].

Anti-cancer

Bfl-1-IN-7 reduces the viability of SU-DHL-1 lymphoma cells, with an EC₅₀ of 0.21 μM at 24 h^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Parmacokinetics

Species	Dose	Route	CL	V_ss	T_1/2	F
Mice^[1]	0.5 mg/kg	i.v.	111 mL/min/kg	13.6 L/kg	2.4 h	/
Mice^[1]	1 mg/kg	p.o.	/	/	/	53 %

Chemical Information

Masse moléculaire 461.48
Formule C₂₄H₂₆F₃N₃O₃
SMILES

C=CC(N([C@@H](C)C1=CC=C(NC([C@@H]2CCC[C@H]2N)=O)C=C1)C3=CC=C(OC(F)(F)F)C=C3)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Blackwell JH, et al. Optimization and Chemoproteomic Profiling of a Selective, Covalent Bfl-1-Targeting Cellular Tool. Journal of medicinal chemistry. 2026 Jan 22;69(2):1218-1246. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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Bfl-1-IN-7

Voir tous les produits spécifiques à Isoform Bcl-2 Family

Voir tous les produits spécifiques à Isoform Caspase