CDK2-IN-47
CDK2-IN-47 is a potent CDK2 inhibitor with an IC50 of 0.21 μM. CDK2-IN-47 exhibits outstanding anticancer activity against MCF-7, HCT-116, and MGC-803 cell lines. CDK2-IN-47 effectively induces G1 cell cycle arrest, retinoblastoma protein (Rb) dephosphorylation, and significant apoptosis. CDK2-IN-47 can be used for the studies of breast cancer, colorectal cancer and gastric cancer.
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- Formule: C16H23N5O4S
- Masse moléculaire:381.45
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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CDK2 0.21 μM (IC50) |
CDK1 1.80 μM (IC50) |
CDK7 8.70 μM (IC50) |
CDK9 2.30 μM (IC50) |
CDK4 > 10 μM (IC50) |
CDK6 > 10 μM (IC50) |
CDK2-IN-47 (Compound 14c) (72 h) exhibits outstanding anticancer activity against MCF-7 (IC50 = 0.7 μM), HCT-116 (IC50 = 1.1 μM), and MGC-803 (IC50 = 1.5 μM) cell lines, coupled with remarkable selectivity over non-cancerous HEK293 cells (SI = 22.4)[1].
CDK2-IN-47 (0.7 μM, 48 h) induces significant apoptosis in MCF-7 cells[1].
CDK2-IN-47 (0.7 μM, 24 h) induces G0/G1 phase phase arrest in MCF-7 cells[1].
CDK2-IN-47 leads to a significant reduction in Rb phosphorylation at Ser807/811 in MCF-7 cells[1].
CDK2-IN-47 demonstrates high metabolic stability in human liver microsomes (t½ = 68.5 min, CLint = 8.5 mL/min/kg)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | Note |
|---|---|---|---|
| Rat | 1 mg/kg | i.v. | male |
Chemical Information
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Masse moléculaire 381.45
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Formule C16H23N5O4S
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SMILES
O=C1C(C)=CN(CC(N[C@H](CC(C)C)C(OC)=O)=O)C2=NC(SC)=NN12
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CDK2-IN-47 Related Classifications
HY-178112 Related Classifications
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