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Cat. No.: HY-171184

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EAPB0503

EAPB0503 is a quinoline compound with anti-tumor activity, showing strong cytotoxicity against melanoma cells in vitro (IC₅₀=200 nM). EAPB0503 can induce specific cell cycle arrest in mitosis of CML cells and directly activate apoptosis, leading to an increase in the G0 cell population, disruption of mitochondrial membrane potential, PARP cleavage, and DNA fragmentation. EAPB0503 also reduces the levels of BCR-ABL protein .

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CAS No.: 1140627-77-5
Formule: C₁₈H₁₆N₄O
Masse moléculaire:304.35

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

EAPB0503 Chemical Structure

CAS No.: 1140627-77-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- Cellular Effect
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Activité biologique

Description

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Cellular Effect

Cell Line	Type	Value	Description	References
A2058	IC₅₀	185 nM Compound: EAPB0503	Antiproliferative activity against human A2058 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay Antiproliferative activity against human A2058 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay	[PMID: 33309473]
A-375	IC₅₀	0.2 μM Compound: 7b, EAPB0503	Cytotoxicity against human A375 cells after 96 hrs by MTT assay Cytotoxicity against human A375 cells after 96 hrs by MTT assay	[PMID: 19278757]
A-375	IC₅₀	0.2 μM Compound: EAPB0503	Antiproliferative activity against human A375 cells assessed as cell growth inhibition after 96 hrs by MTT assay Antiproliferative activity against human A375 cells assessed as cell growth inhibition after 96 hrs by MTT assay	[PMID: 27094151]
A-375	IC₅₀	383 nM Compound: EAPB0503	Antiproliferative activity against human A-375 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay Antiproliferative activity against human A-375 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay	[PMID: 33309473]
IPC-298	IC₅₀	469 nM Compound: EAPB0503	Antiproliferative activity against human IPC-298 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay Antiproliferative activity against human IPC-298 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay	[PMID: 33309473]
MeWo	IC₅₀	125 nM Compound: EAPB0503	Antiproliferative activity against human MeWo cells assessed as reduction in cell viability measured after 96 hrs by MTT assay Antiproliferative activity against human MeWo cells assessed as reduction in cell viability measured after 96 hrs by MTT assay	[PMID: 33309473]

Chemical Information

CAS No. 1140627-77-5
Masse moléculaire 304.35
Formule C₁₈H₁₆N₄O
SMILES

COC1=CC(C2=CN=C3N2C4=C(C=CC=C4)N=C3NC)=CC=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Sonia Khier, et al. Quantitation of imidazo[1,2-a]quinoxaline derivatives in human and rat plasma using LC/ESI-MS. J. Sep. Sci. 2009, 32, 1363-1373.

[2]. Jessica Saliba, et al. EAPB0503, a novel imidazoquinoxaline derivative, inhibits growth and induces apoptosis in chronic myeloid leukemia cells. Anticancer Drugs. 2014 Jul;25(6):624-32. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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EAPB0503

Voir tous les produits spécifiques à Isoform PARP

Voir tous les produits spécifiques à Isoform Bcr-Abl

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EAPB0503 Related Classifications

HY-171184 Related Classifications