EC-70124
EC-70124 is an orally active multikinase inhibitor targeting IKKβ and JAK2. EC-70124 blocks IkB phosphorylation and STAT3 (Tyr705) activation, suppressing NF-κB nuclear translocation and STAT3 transcriptional activity. EC-70124 reduces tumor growth and cancer stem cell (CSC) populations in prostate cancer cells and xenograft models. EC-70124 is promising for research of prostate cancer.
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- CAS No.: 1185908-92-2
- Formule: C26H19N3O5
- Masse moléculaire:453.45
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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JAK2 |
NF-κB |
IKKβ |
STAT3 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MOLM-13 | IC50 |
13 nM
Compound: EC-70124
|
Antiproliferative activity against human MOLM-13 cells expressing FLT3-ITD mutant assessed as inhibition of cell proliferation measured after 72 hrs by celltiter-glo luminescent cell viability assay
Antiproliferative activity against human MOLM-13 cells expressing FLT3-ITD mutant assessed as inhibition of cell proliferation measured after 72 hrs by celltiter-glo luminescent cell viability assay
|
[PMID: 32659083] |
| MOLM-16 | IC50 |
27 nM
Compound: EC-70124
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Antiproliferative activity against human MOLM16 cells expressing FLT3-ITD mutant assessed as inhibition of cell proliferation measured after 72 hrs by celltiter-glo luminescent cell viability assay
Antiproliferative activity against human MOLM16 cells expressing FLT3-ITD mutant assessed as inhibition of cell proliferation measured after 72 hrs by celltiter-glo luminescent cell viability assay
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[PMID: 32659083] |
| MV4-11 | IC50 |
12.27 nM
Compound: EC-70124
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Antiproliferative activity against human MV4-11 cells assessed as reduction in cell proliferation measured after 24 hrs by MTT assay
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell proliferation measured after 24 hrs by MTT assay
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[PMID: 32659083] |
Chemical Information
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CAS No. 1185908-92-2
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Masse moléculaire 453.45
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Formule C26H19N3O5
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SMILES
C[C@]12N3C4=C(C5=CC=CC=C53)C(C(NC6=O)=O)=C6C7=C4N([C@](C[C@@H]([C@H]2O)O)([H])O1)C8=CC=CC=C78
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EC-70124 Related Classifications
HY-124067 Related Classifications
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