Fepradinol
Fepradinol is an orally active nonsteroidal anti-inflammatory agent. Fepradinol inhibits the increase in vascular permeability induced by histamine, 5-hydroxytryptamine, and bradykinin, reduces exudate volume, prevents leukocyte migration, and suppresses acute inflammation models. Fepradinol also induces thrombotic vasculopathy with epidermal necrosis, without leukocytoclastic vasculitis; triggers occlusive contact dermatitis presenting as purpuric papulonecrotic lesions, and causes strongly positive patch test reactions. Fepradinol can be used in research related to occlusive contact dermatitis and acute inflammation.
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- CAS No.: 36981-91-6
- Formule: C12H19NO2
- Masse moléculaire:209.28
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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- Pureté et documentation
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Activité biologique
Description
In Vivo
Fepradinol (25 mg/kg; oral; single administration; 30 minutes before zymosan injection) inhibited dye exudation by 67.2% in the early phase (30 min) of zymosan-induced rat peritonitis, and reduced exudate volume by 27% and dye exudation by 50% in the late phase (3 h)[2].
Fepradinol (100 mg/kg; oral; single administration; administered immediately after carrageenan injection) reduced exudate volume by 67.2% and leukocyte migration by 76.4% in a carrageenan-induced rat pleurisy model[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar (male, 5-7 weeks old, 150-200 g)[2]
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Dosage:25 mg/kg
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Administration:p.o.; single dose; 30 min prior to mediator injection
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Result:Inhibited histamine-induced vascular permeability by 81.1%.
Inhibited serotonin-induced vascular permeability by 82.0%.
Inhibited bradykinin-induced vascular permeability by 64.1%.
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Animal Model:Wistar (male, 150-200 g)[2]
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Dosage:100 mg/kg
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Administration:p.o.; single dose; immediately after carrageenin injection
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Result:Reduced pleural exudate volume by 67.2%.
Inhibited leucocyte mobilization by 76.4%.
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Animal Model:Wistar (male, 150-200 g)[2]
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Dosage:25 mg/kg
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Administration:p.o.; single dose; 30 min prior to zymosan injection
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Result:Inhibited dye extravasation by 67.2% at 30 min after zymosan challenge with no effect on exudate volume.
Reduced exudate volume by 27% at 3 h after zymosan challenge.
Inhibited dye extravasation by 50% at 3 h after zymosan challenge.
Chemical Information
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CAS No. 36981-91-6
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Masse moléculaire 209.28
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Formule C12H19NO2
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SMILES
OC(CNC(C)(C)CO)C1=CC=CC=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Fepradinol Related Classifications
HY-118854 Related Classifications
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