Fuscin
Fuscin, a fungal metabolite, CCR5 receptor antagonist with anti-HIV effects. Fuscin is a respiration and oxidative phosphorylation inhibitor, and also a mitochondrial SH-dependent transport-linked functions inhibitor.
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- CAS No.: 83-85-2
- Formule: C15H16O5
- Masse moléculaire:276.28
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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HIV |
CCR5 |
Microbial Metabolite |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
21 μM
Compound: 3
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Displacement of [125I]human-MIP1-alpha from human CCR5 receptor expressed in CHO cells by SPA
Displacement of [125I]human-MIP1-alpha from human CCR5 receptor expressed in CHO cells by SPA
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[PMID: 12932138] |
Chemical Information
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CAS No. 83-85-2
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Masse moléculaire 276.28
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Formule C15H16O5
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SMILES
O=C1C=C2C(C(C)O1)=C(O)C(C3=C2CCC(C)(C)O3)=O
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Structure Classification
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Initial Source
soil fungus Oidiodendron griseum
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. K Yoganathan, et al. 10-Methoxydihydrofuscin, fuscinarin, and fuscin, novel antagonists of the human CCR5 receptor from Oidiodendron griseum. J Nat Prod. 2003 Aug;66(8):1116-7. [Content Brief]
[2]. K S Cheah. Fuscin, an inhibitor of respiration and oxidative phosphorylation in ox-neck muscle mitochondria. Biochim Biophys Acta.1972 Jul 12;275(1):1-9. [Content Brief]
[3]. P M Vignais, et al. Fuscin, an inhibitor of mitochondrial SH-dependent transport-linked functions. Biochim Biophys Acta. 1973 Dec 14;325(3):357-74. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Fuscin Related Classifications
HY-111321 Related Classifications
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