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Cat. No.: HY-P2185

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NFF-3

NFF-3 is a MMP-3-selective fluorescent peptide substrate that is efficiently hydrolyzed by MMP-3. NFF-3 can be used in research related to MMP-3 enzyme activity detection.

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CAS No.: 158584-09-9
Formule: C₇₈H₁₁₀N₂₂O₂₀
Masse moléculaire:1675.84

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Please store the product under the recommended conditions in the Certificate of Analysis.

NFF-3 Chemical Structure

CAS No.: 158584-09-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
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Classifications
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Description

NFF-3 is a MMP-3-selective fluorescent peptide substrate that is efficiently hydrolyzed by MMP-3. NFF-3 can be used in research related to MMP-3 enzyme activity detection^[1]^[2]^[3].

IC₅₀ & Target

^[1]

MMP-3

Voir tous les produits spécifiques à Isoform MMP :

In Vitro

NFF-3 is a substrate that is rapidly hydrolyzed by MMP-3 in a continuous fluorescence assay^[1].
NFF-3 is hydrolyzed by MMP-3 with k_cat/K_m = 218,000 s^-1 M^-1, whereas MMP-1 and MMP-2 show no detectable hydrolysis, and MMP-9 exhibits much lower efficiency (10,100 s^-1 M^-1)^[2].
NFF-3 confers MMP-3-triggered degradability on chitosan microspheres (CNMS) in the bacterial infection microenvironment^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 158584-09-9
Masse moléculaire 1675.84
Formule C₇₈H₁₁₀N₂₂O₂₀
Sequence

{Mca}-Arg-Pro-Lys-Pro-Val-Glu-{Nva}-Trp-Arg-Lys(DNP)-NH2
Sequence Shortening

{Mca}-RPKPVE-{Nva}-WR-{K(DNP)}-NH2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Cheng L, et al. Bioresponsive micro-to-nano albumin-based systems for targeted drug delivery against complex fungal infections. Acta pharmaceutica Sinica. B. 2021 Oct;11(10):3220-3230.

[2]. Nagase H, et al. Design and characterization of a fluorogenic substrate selectively hydrolyzed by stromelysin 1 (matrix metalloproteinase-3). The Journal of biological chemistry. 1994 Aug 19;269(33):20952-7.

[3]. Cheng D, et al. High-performance lung-targeted bio-responsive platform for severe colistin-resistant bacterial pneumonia therapy. Bioactive materials. 2024 May;35:517-533.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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NFF-3

Voir tous les produits spécifiques à Isoform MMP

Activité biologique

Description

IC50 & Target

In Vitro

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

NFF-3 Related Classifications

HY-P2185 Related Classifications

Bioz

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