PEAQX
Based on 8 publication(s) in Google Scholar
PEAQX (NVP-AAM077) is an orally active and selective NMDA antagonist, with IC50 values of 270 nM and 29.6 μM for hNMDAR 1A/2A and hNMDAR 1A/2B, respectively. PEAQX can promote the activation of caspase-3 and induce cell apoptosis in cortical striatal slice cultures.
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- CAS No.: 459836-30-7
- Formule: C17H17BrN3O5P
- Masse moléculaire:454.21
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) PEAQX
More- J Clin Invest. 2019 Sep 3;129(9):3864-3876. [Abstract]
- Brain Behav Immun. 2026 Jul:135:106529. [Abstract]
- Neurosci Bull. 2025 Apr 28. [Abstract]
- Cells. 2023 Apr 22;12(9):1212. [Abstract]
- Front Neurosci. 2021 Sep 30:15:703044. [Abstract]
- Neuroscience. 2018 Nov 1:391:1-12. [Abstract]
- Am J Hypertens. 2021 Aug 9;34(8):840-850. [Abstract]
- bioRxiv. 2025 Sep 27.
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Activité biologique
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NMDA Receptor |
PEAQX (10 mg/kg; once daily; i.p.) can block the CaMKIV-TORC1-CREB pathway signal induced by sigma-1 receptor (σ 1r) agonists in mice with cerebral ischemia and improve learning and memory impairments[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Pups obtained from deliveries of pregnant female Sprague-Dawley rats[2].
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Dosage:10, 20, 40 mg/kg
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Administration:Subcutaneous injection (s.c.)
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Result:Resulted in an 8-fold increase in caspase-3 activity in the striatum when administered at a dose of 20 mg/kg.
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Animal Model:11-week old C57BL/6 mice with cerebral ischemia[3].
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Dosage:10 mg/kg
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Administration:Intraperitoneal injection (i.p.); once daily; 4 days
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Result:Reduced protein expression levels in the CaMKIV-TORC1-p-CREB-BDNF pathway.
Chemical Information
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CAS No. 459836-30-7
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Masse moléculaire 454.21
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Formule C17H17BrN3O5P
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SMILES
O=C1C(NC2=C(C(C(P(O)(O)=O)N[C@H](C3=CC=C(Br)C=C3)C)=CC=C2)N1)=O
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Synonyms
NVP-AAM077
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (8)
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Journal Impact Factor
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Most Recent
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J Clin Invest
2019 Sep 3;129(9):3864-3876. PMID: 31424425 -
Brain Behav Immun
NR2B-CaMKII signaling in the dentate gyrus driven by astrocytic P2Y1Rs mediates the antidepressant effect of low-dose LPS. [Abstract]2026 Jul:135:106529. PMID: 41796645 -
Neurosci Bull
Upregulation of NR2A in Glutamatergic VTA Neurons Contributes to Chronic Visceral Pain in Male Mice. [Abstract]2025 Apr 28. PMID: 40293685 -
Cells
2023 Apr 22;12(9):1212. PMID: 37174612 -
Front Neurosci
GluN2A/ERK/CREB Signaling Pathway Involved in Electroacupuncture Regulating Hypothalamic-Pituitary-Adrenal Axis Hyperactivity. [Abstract]2021 Sep 30:15:703044. PMID: 34658758 -
Neuroscience
Src is Implicated in Hepatic Ischemia Reperfusion-Induced Hippocampus Injury and Long-Term Cognitive Impairment in Young Mice via NMDA Receptor Subunit 2A Activation. [Abstract]2018 Nov 1:391:1-12. PMID: 30213765
PEAQX purchased from MedChemExpress. Usage Cited in: Neuroscience. 2018 Nov 1:391:1-12. [Abstract]
PP2 and NVP-AAM077 pretreatment decreases the expression level of Cleaved Caspase-3 significantly.
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Am J Hypertens
Chronic Blockade of NMDAR Subunit 2A in the Hypothalamic Paraventricular Nucleus Alleviates Hypertension Through Suppression of MEK/ERK/CREB Pathway. [Abstract]2021 Aug 9;34(8):840-850. PMID: 33856436 -
Solvant et solubilité
The following protocol is derived from the literature and is for reference only. It is recommended to first try a small sample.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Pureté et documentation
Références
[1]. Auberson YP, et al. 5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1099-102. [Content Brief]
[2]. Anastasio NC, et al. Differential role of N-methyl-D-aspartate receptor subunits 2A and 2B in mediating phencyclidine-induced perinatal neuronal apoptosis and behavioral deficits. Neuroscience. 2009 Nov 10;163(4):1181-91. [Content Brief]
[3]. Qian Xu, et al. Sigma-1 receptor in brain ischemia/reperfusion: Possible role in the NR2A-induced pathway to regulate brain-derived neurotrophic factor. J Neurol Sci. 2017 May 15;376:166-175. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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