QTX125
Based on 1 publication(s) in Google Scholar
QTX125 is a potent and highly selective HDAC6 inhibitor. QTX125 exhibits excellent selectivity over other HDACs. QTX125 has antitumor effects.
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- CAS No.: 1279698-31-5
- Formule: C23H19N3O5
- Masse moléculaire:417.41
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Publications Citing Use of MedChemExpress (MCE) QTX125
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Activité biologique
Description
IC50 & Target
[1]|
HDAC6 |
In Vitro
QTX125 (25-500 nM; 24-48 hours) treatment induces the subsequent apoptosis demonstrated by annexin V/propidium iodide double staining and the cleavage of caspase-9, caspase-8, caspase-3, and PARP[1].
In MCL cell lines MINO, REC-1, IRM-2 and HBL-2 cells, QTX125 (10 nM, 10 μM, 100 μM) induces dose-dependent hyperacetylation of α-tubulin[1].
QTX125 has the strongest growth-inhibitory effect in Burkitt cell lymphoma, follicular lymphoma, and mantle cell lymphoma (MCL)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MINO, REC-1, IRM-2 and HBL-2 cells
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Concentration:25 nM, 50 nM, 100 nM, 500 nM
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Incubation Time:24 hours, 48 hours
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Result:Inhibited annexin V/propidium iodide double staining.
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Cell Line:MINO, REC-1, IRM-2 and HBL-2 cells
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Concentration:25 nM, 50 nM, 100 nM, 500 nM
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Incubation Time:24 hours
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Result:Inhibited the cleavage of caspase-9, caspase-8, caspase-3, and PARP.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Nude mice bearing REC-1 or MINO cells[1]
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Dosage:60 mg/kg
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Administration:Intraperitoneal administration; daily dosing for 5 days; for 4 weeks
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Result:Inhibited tumor growth in REC-1 or MINO cells xenografted in nude mice.
Chemical Information
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CAS No. 1279698-31-5
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Masse moléculaire 417.41
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Formule C23H19N3O5
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SMILES
O=C(C1=C(C2=COC=C2)C=C(C3=CC=C(O)C=C3)N1)NCC4=CC=C(C(NO)=O)C=C4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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J Nanobiotechnology
Multifunctional CaCO3@Cur@QTX125@HA nanoparticles for effectively inhibiting growth of colorectal cancer cells. [Abstract]2023 Sep 29;21(1):353. PMID: 37773145
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
QTX125 Related Classifications
HY-120448 Related Classifications
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