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Cat. No.: HY-119690

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T326

T326 is a potent and selective HDAC3 inhibitor, with an IC₅₀ of 0.26 μM. T326 can be used for the research of cancer and HIV infection.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 1451042-19-5
Formule: C₂₁H₁₈N₆O₃S
Masse moléculaire:434.47

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

T326 Chemical Structure

CAS No.: 1451042-19-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- Essai clinique
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

T326 is a potent and selective HDAC3 inhibitor, with an IC₅₀ of 0.26 μM. T326 can be used for the research of cancer and HIV infection^[1].

Voir tous les produits spécifiques à Isoform HDAC :

Voir tous les produits spécifiques à Isoform HIV :

Cellular Effect

Cell Line	Type	Value	Description	References
Sf9	IC₅₀	>100 μM Compound: 74	Inhibition of recombinant human full length C-terminal GST-tagged HDAC1 expressed in baculovirus Sf9 insect cells using HDAC Glo I/II substrate by Kinase Glo luminescence assay Inhibition of recombinant human full length C-terminal GST-tagged HDAC1 expressed in baculovirus Sf9 insect cells using HDAC Glo I/II substrate by Kinase Glo luminescence assay	[PMID: 31050421]
Sf9	IC₅₀	>100 μM Compound: 74	Inhibition of recombinant human full length C-terminal GST-tagged HDAC4 (627 to end residues) expressed in baculovirus Sf9 insect cells using HDAC class 2a substrate incubated for 30 mins by fluorescence assay Inhibition of recombinant human full length C-terminal GST-tagged HDAC4 (627 to end residues) expressed in baculovirus Sf9 insect cells using HDAC class 2a substrate incubated for 30 mins by fluorescence assay	[PMID: 31050421]

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 1451042-19-5
Masse moléculaire 434.47
Formule C₂₁H₁₈N₆O₃S
SMILES

O=C(NC1=CC=CC=C1N)C2=CC=C(S2)C3=CN(CCC4=CC=CC([N+]([O-])=O)=C4)N=N3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Suzuki T, et, al. Identification of highly selective and potent histone deacetylase 3 inhibitors using click chemistry-based combinatorial fragment assembly. PLoS One. 2013 Jul 16;8(7):e68669. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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Activité biologique
- Description
- Essai clinique
Chemical Information
Pureté et documentation
Références

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T326

Voir tous les produits spécifiques à Isoform HDAC

Voir tous les produits spécifiques à Isoform HIV