1. Cell Cycle/DNA Damage
  2. CDK
  3. CDK7/12-IN-1

CDK7/12-IN-1 is a selective CDK7/12 inhibitor with IC50s of 3 and 277 nM for CDK7 and CDK 12, respectively. CDK7 and CDK12 inhibition is an effective strategy to inhibit tumour growth.

For research use only. We do not sell to patients.

CDK7/12-IN-1 Chemical Structure

CDK7/12-IN-1 Chemical Structure

CAS No. : 2654075-94-0

Size Price Stock Quantity
1 mg USD 520 In-stock
5 mg USD 1460 In-stock
10 mg USD 2280 In-stock
25 mg USD 4500 In-stock
50 mg USD 6800 In-stock
100 mg USD 10800 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

CDK7/12-IN-1 is a selective CDK7/12 inhibitor with IC50s of 3 and 277 nM for CDK7 and CDK 12, respectively. CDK7 and CDK12 inhibition is an effective strategy to inhibit tumour growth[1].

Molecular Weight

462.59

Formula

C25H34N8O

CAS No.
Appearance

Solid

Color

White to light brown

SMILES

O[C@H]1CNCC[C@@H]1CNC2=NC3=C(C(C)C)C=NN3C(NCC4=C(C)N=C5C=C(C)C=CN54)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (216.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1617 mL 10.8087 mL 21.6174 mL
5 mM 0.4323 mL 2.1617 mL 4.3235 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1617 mL 10.8087 mL 21.6174 mL 54.0435 mL
5 mM 0.4323 mL 2.1617 mL 4.3235 mL 10.8087 mL
10 mM 0.2162 mL 1.0809 mL 2.1617 mL 5.4044 mL
15 mM 0.1441 mL 0.7206 mL 1.4412 mL 3.6029 mL
20 mM 0.1081 mL 0.5404 mL 1.0809 mL 2.7022 mL
25 mM 0.0865 mL 0.4323 mL 0.8647 mL 2.1617 mL
30 mM 0.0721 mL 0.3603 mL 0.7206 mL 1.8015 mL
40 mM 0.0540 mL 0.2702 mL 0.5404 mL 1.3511 mL
50 mM 0.0432 mL 0.2162 mL 0.4323 mL 1.0809 mL
60 mM 0.0360 mL 0.1801 mL 0.3603 mL 0.9007 mL
80 mM 0.0270 mL 0.1351 mL 0.2702 mL 0.6755 mL
100 mM 0.0216 mL 0.1081 mL 0.2162 mL 0.5404 mL
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CDK7/12-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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CDK7/12-IN-1
Cat. No.:
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