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Gemcitabine

(Synonyms: LY 188011)
276 Cited Publications
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Based on 276 publication(s) in Google Scholar

Gemcitabine (LY 188011) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine inhibits DNA synthesis and repair, and can modulate autophagy. Gemcitabine induces apoptosis through the activation of p38 MAPK. Gemcitabine demonstrates efficacy in mouse models of pancreatic and breast cancer. Gemcitabine can be used for cancer research, such as pancreatic cancer, non-small cell lung cancer, and breast cancer.

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  • Reinheit: 99.95%
  • CAS. Nr.: 95058-81-4
  • Formel: C9H11F2N3O4
  • Molecular Weight:263.20
  • Speicherung:

    4°C, protect from light

    * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

  • Gemcitabine Chemical Structure
  • Experimental Validation Results for Gemcitabine
  • Experimental Validation Results for Gemcitabine
  • Experimental Validation Results for Gemcitabine
  • Experimental Validation Results for Gemcitabine
  • Experimental Validation Results for Gemcitabine
  • Experimental Validation Results for Gemcitabine
  • Experimental Validation Results for Gemcitabine
  • Experimental Validation Results for Gemcitabine
  • Experimental Validation Results for Gemcitabine
  • Experimental Validation Results for Gemcitabine
  • Experimental Validation Results for Gemcitabine
  • Experimental Validation Results for Gemcitabine
  • Experimental Validation Results for Gemcitabine
  • Experimental Validation Results for Gemcitabine
  • Experimental Validation Results for Gemcitabine
  • Experimental Validation Results for Gemcitabine
  • Experimental Validation Results for Gemcitabine
  • Gemcitabine Chemical Structure
    Gemcitabine Chemical Structure
  • Experimental Validation Results for Gemcitabine
  • Experimental Validation Results for Gemcitabine
  • Experimental Validation Results for Gemcitabine
  • Experimental Validation Results for Gemcitabine
  • Experimental Validation Results for Gemcitabine
  • Experimental Validation Results for Gemcitabine
  • Experimental Validation Results for Gemcitabine
  • Experimental Validation Results for Gemcitabine
  • Experimental Validation Results for Gemcitabine
  • Experimental Validation Results for Gemcitabine
  • Experimental Validation Results for Gemcitabine
  • Experimental Validation Results for Gemcitabine
  • Experimental Validation Results for Gemcitabine
  • Experimental Validation Results for Gemcitabine
  • Experimental Validation Results for Gemcitabine
  • Experimental Validation Results for Gemcitabine
  • Experimental Validation Results for Gemcitabine
CAS. Nr.: 95058-81-4
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  • Gemcitabine Chemical Structure
    Gemcitabine Chemical Structure
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  • 1/16

    Gemcitabine purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2025 Aug 6;16(1):592. [Abstract]

    Customer Validation
     Kaplan–Meier curve of #354 cells subcutaneously xenografted, treated or not with Gemcitabine hydrochloride (Gem, 100 mg/kg; i.p.; biweekly for three weeks) and/or TRL (50 mg/kg; i.p.; biweekly for three weeks).

  • 1/16

    Gemcitabine purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2025 Aug 6;16(1):592. [Abstract]

    Customer Validation
     Gemcitabine hydrochloride (Gem, 100 mg/kg; i.p.; biweekly for three weeks). Left: Representative histological sections of xenografts derived from #354 cells. Tumor sections were stained with Hematoxylin & Eosin (H&E). S stroma; T tumor. Right: quantification of stroma content on H&E-stained sections.

  • 1/16

    Gemcitabine purchased from MedChemExpress. Usage Cited in: Nat Med. 2024 Mar;30(3):749-761. [Abstract]

    Customer Validation
     The relative cell viability of shCtl-, shNDUFB8-, and shCEMIP2-transfected cells was detected by XTT assay after paclitaxel plus gemcitabine (100 nM) treatment (A+G), single-agent 5-Fu (5-FU), and the FOLFIRINOX chemotherapy cocktail [FU+IRI+OXA: 5-FU+Irinotecan (SN-38) +Oxaliplatin] for 48h.

  • 1/16

    Gemcitabine purchased from MedChemExpress. Usage Cited in: Mol Cancer. 2024 Apr 29;23(1):86. [Abstract]

    Customer Validation
     The cell viability of the indicated T24 cells was determined after 48 h of continuous exposure to multiple concentrations of gemcitabine.

  • 1/16

    Gemcitabine purchased from MedChemExpress. Usage Cited in: Mol Cancer. 2024 Apr 29;23(1):86. [Abstract]

    Customer Validation
     ATR-Chk1 pathway protein levels in the indicated T24 cells treated with 20 µg/L Gemcitabine for 6 h were determined by Western blotting.

  • 1/16

    Gemcitabine purchased from MedChemExpress. Usage Cited in: J Clin Invest. 2024 Mar 7;134(10):e172716. [Abstract]

    Customer Validation
     The given cell lines were treated with 250 nM osimertinib (Osim), 1.25 μM Etoposide (VP-16), 125 nM Doxorubicin (DXR), 5 nM Paclitaxel, 10 μM Cisplatin, 25 μM Carboplatin, 25 nM Gemcitabine, 20 nM 5-Fluorouracil (5-FU), 25 μM Cyclophosphamide, 25 μM Capecitabine, or 10 nM Vincristine alone or in combination for 3 days. Cell numbers were then measured using the SRB assay.

  • 1/16

    Gemcitabine purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2024 Apr 10:587:216696. [Abstract]

    Customer Validation
     Endogenous LDHA was knocked out or ZDHHC9 was knocked down in SW1990 cells. Cells were then exposed to indicated concentrations of Gemcitabine hydrochloride for 72 h, and cell viability assays were performed. The IC50 of gemcitabine was calculated for each group.

  • 1/16

    Gemcitabine purchased from MedChemExpress. Usage Cited in: Mol Cancer. 2023 Dec 4;22(1):195. [Abstract]

    Customer Validation
     CCK-8 (0.1-102.4 µM; 24 h) analysis of the sensitivity of normal and GEM-resistant PDAC cells under different concentrations of gemcitabine (GEM).

  • 1/16

    Gemcitabine purchased from MedChemExpress. Usage Cited in: Mol Cancer. 2023 Dec 4;22(1):195. [Abstract]

    Customer Validation
     Comet analysis of the DNA damage of GEM-resistant PDAC cells with or without hsa_circ_0007919 inhibition and of the DNA damage of PDAC cells with or without hsa_circ_0007919 overexpression under gemcitabine (GEM) treatment condition (200×).

  • 1/16

    Gemcitabine purchased from MedChemExpress. Usage Cited in: Mol Cancer. 2023 Dec 4;22(1):195. [Abstract]

    Customer Validation
     IF analysis of γ-H2AX accumulation in GEM-resistant PDAC cells with or without hsa_circ_0007919 inhibition and of γ-H2AX accumulation in PDAC cells with or without hsa_circ_0007919 overexpression under gemcitabine (GEM) treatment condition (1000×).

  • 1/16

    Gemcitabine purchased from MedChemExpress. Usage Cited in: Mol Cancer. 2023 Dec 4;22(1):195. [Abstract]

    Customer Validation
     Expression of apoptosis-related proteins in hsa_circ_0007919-inhibited gemcitabine (GEM)-resistant PDAC cells with or without LIG1 overexpression.

  • 1/16

    Gemcitabine purchased from MedChemExpress. Usage Cited in: Chem Biol Interact. 2024 Jan 5:387:110816. [Abstract]

    Customer Validation
     The impact of PKM2 knockdown on gemcitabine sensitivity in ICC cells was assessed by CCK-8 assays. The cells were exposed to Gemcitabine hydrochloride (0.01-100 μM) for a duration of 72 h.

  • 1/16

    Gemcitabine purchased from MedChemExpress. Usage Cited in: JCI Insight. 2022 Nov 22;7(22):e159419. [Abstract]

    Customer Validation
     Similarly, Gemcitabine hydrochloride (Gem, 150 mg/kg) + decitabine (DAC) efficacy was preserved in immune-deficient allografts in NSG mice (n = 8–9/group).

  • 1/16

    Gemcitabine purchased from MedChemExpress. Usage Cited in: Gastroenterology. 2021 Nov;161(5):1601-1614.e23. [Abstract]

    Customer Validation
     Bar graphs show the GI50 of 5-fluoruracil (48 h), irinotecan (48 h), gemcitabine (48 h), paclitaxel (48 h), and oxaliplatin (48 h) in PDAC cells in combination with bioactive hexapeptides (NTAIYY and PTTIYY) or controls (saline and NTAIYA).

  • 1/16

    Gemcitabine purchased from MedChemExpress. Usage Cited in: Naunyn Schmiedebergs Arch Pharmacol. 2019 May;392(5):615-622. [Abstract]

    Customer Validation
     The expression level of p-JAK2, p-STAT3, Bcl-XL, and Mcl-1 in PANC-1 cells is detected by western blot analysis and is all down-regulated in the treatment groups.

  • 1/16

    Gemcitabine purchased from MedChemExpress. Usage Cited in: Chem Biol Interact. 2018 Jun 25:290:44-51. [Abstract]

    Customer Validation
     U2OS and MG-63 cells are treated with Gemcitabine, Licoricidin, or Gemcitabine+Licoricidin for 24 h, followed by the determination of active caspse-3 protein level using western blot. Cells without treatment are used as Control.

  • 1/16

    Gemcitabine purchased from MedChemExpress. Usage Cited in: J Biol Chem. 2017 Jun 2;292(22):9136-9149. [Abstract]

    Customer Validation
     The plate clone formation of SW480 and SW620 cells with Gemcitabine (8 nM in SW480 and 16 nM in SW620) and/or PX-12 (4 μM in SW480 and 8 μM in SW620).

  • Gemcitabine