Art. -Nr.: HY-B1119

Triclosan

10 Cited Publications

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Based on 10 publication(s) in Google Scholar

Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC₅₀s of 2 µM and 10 µM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models.

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Reinheit: 99.98%
CAS. Nr.: 3380-34-5
Formel: C₁₂H₇Cl₃O₂
Molecular Weight:289.55

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Triclosan Chemical Structure

CAS. Nr.: 3380-34-5

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (10)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Antibiotic Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
B-cell	IC₅₀	20 μM Compound: Triclosan	Antiproliferative activity against Theileria parva-induced proliferation of bovine B lymphocyte assessed as inhibition of [3H]thymidine uptake after 48 hrs Antiproliferative activity against Theileria parva-induced proliferation of bovine B lymphocyte assessed as inhibition of [3H]thymidine uptake after 48 hrs	[PMID: 19075064]
HepG2	ED₅₀	2 μg/mL Compound: Triclosan	Cytotoxicity against human HepG2 cells Cytotoxicity against human HepG2 cells	[PMID: 23092194]
Vero	CC₅₀	25 μM Compound: TCS	Cytotoxicity against African green monkey Vero cells assessed as inhibition of cell proliferation Cytotoxicity against African green monkey Vero cells assessed as inhibition of cell proliferation	[PMID: 33636304]

In Vitro

Triclosan (1-100 μM ; 24 h) decreases in cell viability in dose and time dependent manners with 50 and 100 μM. Triclosan with 50 μM significantly increases cleaved caspase3 and Bax proteins and decreases Bcl-2^[2].
Triclosan (50 μM ; 1-3 h) induces the increased expressions of both phosphorylated p38 and JNK proteins^[2].
Triclosan (10-50 μM ; 3 h) with 50 μM decreases the GSH activity and increases the ROS generation to about 40% in cultured NSCs^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

Neural stem wells
Concentration:

1, 10, 20, 30, 50 and 100 μM
Incubation Time:

24 h
Result:

Initiated the decreases in cell viability in dose and time dependent manners with 50 and 100 μM.

Western Blot Analysis^[2]

Cell Line:

Neural stem wells
Concentration:

50 μM
Incubation Time:

1, 3 h
Result:

Did not affect the expressions of MAPK signaling proteins per se.
Differentially induced the increased expressions of both phosphorylated p38 and JNK proteins.

In Vivo

Triclosan (5, 50, 500 mg/kg; oral gavage, five days a week for a total of four weeks) causes an increase in the production of anti-Der f IgE, IL-4, and IL-13^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wild type BALB/cJ mice^[3]
Dosage:

5, 50, 500 mg/kg
Administration:

Oral gavage, five days a week for a total of four weeks
Result:

Caused an increase in the production of anti-dermatophagoides farinae (Der f) IgE, IL-4, and IL-13, and this resulted in the aggravation of airway hyperresponsiveness in aeroallergen-exposed wild type mice.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 3380-34-5
Appearance Solid
Molecular Weight 289.55
Formel C₁₂H₇Cl₃O₂
Color White to off-white
SMILES

OC1=CC(Cl)=CC=C1OC2=CC=C(Cl)C=C2Cl
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (10)

All Bio/Physico-chemical AssayWBIHC

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Journal Impact Factor

Antioxidants (Basel)

Pitavastatin Calcium Confers Fungicidal Properties to Fluconazole by Inhibiting Ubiquinone Biosynthesis and Generating Reactive Oxygen Species. [Abstract]

2024 May 29;13(6):667. PMID: 38929106
Anal Chem

Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]

2025 Jun 3;97(21):11099-11109. PMID: 40401576
Anal Chem

Molecular Imaging and In Situ Quantitative Profiling of Fatty Acid Synthase with a Chemical Probe. [Abstract]

2020 Mar 17;92(6):4419-4426. PMID: 32053360
Environ Pollut

Triclosan exposure perturbs skin lipid metabolism and inflammatory pathways: Insights from network toxicology and multi-omics analyses. [Abstract]

2026 Apr 28:128223. PMID: 42061800
Ecotoxicol Environ Saf

Triclosan exposure exacerbates muscle wasting via senescence and IGF-1 pathway suppression: A combined epidemiological and experimental study. [Abstract]

2025 Oct 1:304:119142. PMID: 41045744

Triclosan purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2025 Oct 1:304:119142. [Abstract]

RCS regression analysis between ASMI and cr-corrected Triclosan. Beta (solid lines) and 95% confidence levels (shaded areas).

Triclosan purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2025 Oct 1:304:119142. [Abstract]

Protein levels of IGF-1, p-Akt, and p-mTOR were lower in the muscle of Triclosan (0-50 μM, 48 h)-exposed mice than the chow group.

Triclosan purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2025 Oct 1:304:119142. [Abstract]

IHC staining revealed a lower IGF-1 level in the Triclosan-exposed group than in the chow group.
Ecotoxicol Environ Saf

Microbial profiles and immune responses in seahorse gut and brood pouch under chronic exposure to environmental antibiotics. [Abstract]

2023 Mar 15:253:114711. PMID: 36868035
ACS Omega

Computational Approaches to Identify Molecules Binding to Mycobacterium tuberculosis KasA. [Abstract]

2020 Nov 15;5(46):29935-29942. PMID: 33251429

Triclosan purchased from MedChemExpress. Usage Cited in: ACS Omega. 2020 Nov 15;5(46):29935-29942. [Abstract]

Our data showed that triclosan can stabilize KasA with a △Tm of 3.8℃ using nanoDSF.

Triclosan purchased from MedChemExpress. Usage Cited in: ACS Omega. 2020 Nov 15;5(46):29935-29942. [Abstract]

Ratio of mean fluorescence 350/330 nm (1st derivative). KasA (10 μM) was tested in the presence of 100 μM of compounds. Sildenafil (purple) and triclosan (green) have a ΔTm of 6.7 and 3.8℃, respectively.
Viruses

Screening of an FDA-Approved Drug Library with a Two-Tier System Identifies an Entry Inhibitor of Severe Fever with Thrombocytopenia Syndrome Virus. [Abstract]

2019 Apr 25;11(4):385. PMID: 31027241
SSRN

2025 May 7.
Chemosphere

Mass-balance-model-based evaluation of sewage treatment plant contribution to residual pharmaceuticals in environmental waters. [Abstract]

2019 Jun:225:378-387. PMID: 30884299

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : ≥ 100 mg/mL (345.36 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Methanol : 100 mg/mL (345.36 mM; Need ultrasonic)

H₂O : < 0.1 mg/mL (insoluble)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.4536 mL

17.2682 mL

34.5364 mL

5 mM

0.6907 mL

3.4536 mL

6.9073 mL

10 mM

0.3454 mL

1.7268 mL

3.4536 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (8.63 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (8.63 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (537 KB)
- English - EN (537 KB)
- Français - FR (537 KB)
- Deutsch - DE (537 KB)
- Norwegian - NO (537 KB)
- Español - ES (537 KB)
- Swedish - SV (537 KB)
- Italian - IT (537 KB)
- Korean - KR (537 KB)
- Portuguese - PT (537 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. R J Heath, et al. Mechanism of triclosan inhibition of bacterial fatty acid synthesis. J Biol Chem. 1999 Apr 16;274(16):11110-4. [Content Brief]

[2]. Bo Kyung Park, et al. Effects of Triclosan on Neural Stem Cell Viability and Survival. Biomol Ther (Seoul). 2016 Jan;24(1):99-107. [Content Brief]

[3]. Jianan Zhang, et al. Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract. Nat Commun. 2022 Jan 10;13(1):136. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / Methanol	1 mM	3.4536 mL	17.2682 mL	34.5364 mL	86.3409 mL
	5 mM	0.6907 mL	3.4536 mL	6.9073 mL	17.2682 mL
	10 mM	0.3454 mL	1.7268 mL	3.4536 mL	8.6341 mL
	15 mM	0.2302 mL	1.1512 mL	2.3024 mL	5.7561 mL
	20 mM	0.1727 mL	0.8634 mL	1.7268 mL	4.3170 mL
	25 mM	0.1381 mL	0.6907 mL	1.3815 mL	3.4536 mL
	30 mM	0.1151 mL	0.5756 mL	1.1512 mL	2.8780 mL
	40 mM	0.0863 mL	0.4317 mL	0.8634 mL	2.1585 mL
	50 mM	0.0691 mL	0.3454 mL	0.6907 mL	1.7268 mL
	60 mM	0.0576 mL	0.2878 mL	0.5756 mL	1.4390 mL
	80 mM	0.0432 mL	0.2159 mL	0.4317 mL	1.0793 mL
	100 mM	0.0345 mL	0.1727 mL	0.3454 mL	0.8634 mL

Keywords

Triclosan

10 Cited Publications

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Publications Citing Use of MedChemExpress (MCE) Triclosan

Alle Antibiotic Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (10)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Triclosan Related Classifications

HY-B1119 Related Classifications