Chrysomycin A
Based on 1 Customer Validation
Chrysomycin A (Chr-A), an antibiotic, can be obtained from Streptomyces. Chrysomycin A exhibits antitumor and anti-tuberculous and MRSA activities. As for glioblastoma, Chrysomycin A inhibits the proliferation, migration, and invasion of cancer cells through the Akt/GSK-3β/β-catenin signaling pathway.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.0%
- CAS. Nr.: 82196-88-1
- Formel: C28H28O9
- Molecular Weight:508.52
-
Speicherung:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Alle Antibiotic Isoform-spezifische Produkte anzeigen
More
Biologische Aktivität
Chrysomycin A (0.2-1.8 μM; 48 h) has anti-glioblastoma efficacy, and inhibits cell viability in U251 and U87-MG human glioblastoma, as well as migration and invasion[1].
Chrysomycin A (0.2-1.8 μM; 48 h) inhibits Akt/GSK-3β/β-Catenin signaling pathway in U251 and U87-MG cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:U251 and U87-MG human glioblastoma
-
Concentration:0.2, 0.4 and 0.8 μM for U251; 0.2, 0.6 and 1.8 μM for U87-MG
-
Incubation Time:48 hours
-
Result:Inhibited U251 and U87-MG with 0.475 μM and 1.77 μM, respectively.
-
Cell Line:U251 and U87-MG human glioblastoma
-
Concentration:0.2, 0.4 and 0.8 μM for U251; 0.2, 0.6 and 1.8 μM for U87-MG
-
Incubation Time:48 hours
-
Result:Significantly downregulated the expression of slug and MMP2.
Significantly decreased the protein expression of PI3K-p85, p-PI3K-p85, Akt and p-Akt, as well as c-Myc, cyclin D1.
Chemical Information
-
CAS. Nr. 82196-88-1
-
Appearance Solid
-
Molecular Weight 508.52
-
Formel C28H28O9
-
Color Light yellow to yellow
-
SMILES
O=C1C2=CC(C=C)=CC(OC)=C2C3=CC(OC)=C4C(O)=CC=C([C@H]5[C@@H]([C@]([C@H]([C@@H](C)O5)O)(C)O)O)C4=C3O1
-
Synonyms
Chr-A
-
Initial Source
marine-derived strain Streptomyces sp. 891
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Reinheit & Dokumentation
-
Data Sheet (280 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Chrysomycin A Related Classifications
HY-126771 Related Classifications
Powered by Bioz