Cd38 - CD38 antigen Gene

Also Known as I-19; ADPRC 1; Cd38-rs1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12494

About Cd38

Chromosome 5: 44,025,895-44,069,717 forward strand.GRCm39:CM000998.3

This gene has 2 transcripts (splice variants), 281 orthologues, 1 paralogue and is associated with 23 phenotypes. Broad expression in large intestine adult (RPKM 24.5), colon adult (RPKM 16.5) and 21 other tissues.

Summary

This gene encodes a non-lineage-restricted, type II Transmembrane Glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Knockout mice deficient for this gene display altered humoral immune responses. In addition, knockout mice exhibit higher locomotor activity and defects in nurturing and social behaviors. [provided by RefSeq, Sep 2015]

Cd38 Products (1)

mRNA Protein Name
NM_007646.6 NP_031672.2 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables hydrolase activity, acting on glycosyl bonds IMP
IMP: Inferred from mutant phenotype
12403647 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
22863568 MGI
enables phosphorus-oxygen lyase activity IMP
IMP: Inferred from mutant phenotype
12403647 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of B cell proliferation IDA
IDA: Inferred from direct assay
8666928 MGI
acts upstream of or within positive regulation of B cell proliferation IDA
IDA: Inferred from direct assay
8666928 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in cell surface IDA
IDA: Inferred from direct assay
9324354 MGI
located in membrane IDA
IDA: Inferred from direct assay
12403647 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cd38 Protein Structure

Rib_hydrolayse

Rib_hydrolayse: pfam02267 (58 - 287)

  • 0
  • 100
  • 200
  • 304 a.a.
Protein Preferred Names Protein Names

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

  • 2'-phospho-ADP-ribosyl cyclase

  • 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase

  • 2'-phospho-cyclic-ADP-ribose transferase

  • ADP-ribosyl cyclase 1

  • NIM-R5 antigen

  • cADPr hydrolase 1

  • cyclic ADP-ribose hydrolase 1

Recombinant Cd38 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P70044 CD38 Protein, Mouse (HEK293, Fc) P56528 (L45-T304) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P72732 CD38 Protein, Mouse (HEK293, His) P56528 (L45-T304) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Inhibitory Antibodies (2)
Art. -Nr. Produktname Wirkung
Reinheit Rare Diseases
HY-P9915 Daratumumab 99.10% Unkown
HY-P9976 Isatuximab Inhibitor 98.5% Unkown

Clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-P10563 Noraramtide / Phase 1
Inhibitory Antibodies (8)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-P99616 Felzartamab Inhibitor 99.34% Phase 3
HY-P99730 Mezagitamab Inhibitor 99.76% Phase 3
HY-P9976A Isatuximab (anti-CD38) 98.44% Phase 3
HY-P99744 Modakafusp alfa Inhibitor 96.22% Phase 2
HY-P990037 Erzotabart Inhibitor 99.00% Phase 2
HY-P990747 Lumrotatug Inhibitor 97.00% Phase 2
HY-P991913 CID-103 Inhibitor / Phase 2
HY-P991183 SAR-442257 Inhibitor ≥99.0% Phase 1

Pre-clinical Phase

Bioactive Molecules (16)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-123999 CD38 inhibitor 1 99.83% Unkown
HY-N0640 Kuromanin chloride Inhibitor 99.83% Unkown
HY-150508 MK-0159 Inhibitor 99.72% Unkown
HY-129997 Luteolinidin chloride Inhibitor 99.91% Unkown
HY-144987 RBN013209 98.63% Unkown
HY-134358A Ara-F-NAD+ sodium Inhibitor 99.81% Unkown
HY-186178 CD38-IN-6 Inhibitor 99.96% Unkown
HY-144988 CD38 inhibitor 2 98.81% Unkown
HY-134358 Ara-F-NAD+ Inhibitor / Unkown
HY-182345 NOTA-MK0159 Inhibitor / Unkown
HY-184021 A-8531 Inhibitor / Unkown
HY-184206 A-3190 Inhibitor / Unkown
HY-171417 6-Alkyne-F-araNAD Inhibitor / Unkown
HY-181543 CVN14 Inhibitor / Unkown
HY-164628 CD38-IN-5 Inhibitor / Unkown
HY-119648A (E/Z)-CCR-11 Inhibitor 98.00% Unkown
Inhibitory Antibodies (8)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-P9915A Daratumumab (Anti-CD38) 97.94% Unkown
HY-P990273 Anti-Mouse CD38 Antibody (NIMR5) Inhibitor 95.00% Unkown
HY-P991490 ISB2001 Inhibitor 99.17% Unkown
HY-P991461 AMG-424 Inhibitor 99.32% Unkown
HY-P991715 Sanritatug Inhibitor 99.62% Unkown
HY-P991914 FTL004 Inhibitor / Unkown
HY-P992455 SAR442085 Inhibitor / Unkown
HY-P991462 GBR-1342 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cd38 NCBI NCBI:952