SP1 - Sp1 transcription factor Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6667

About SP1

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:53,380,176-53,416,446 (from NCBI)

This gene has 4 transcripts (splice variants), 195 orthologues and 3 paralogues. Ubiquitous expression in skin (RPKM 18.2), endometrium (RPKM 16.6) and 25 other tissues.

Summary

The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, Apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]

SP1 Products (3)

mRNA	Protein	Name
NM_001251825.2	NP_001238754.1	transcription factor Sp1 isoform c
NM_003109.1	NP_003100.1	transcription factor Sp1 isoform b
NM_138473.3	NP_612482.2	transcription factor Sp1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables DNA binding	IDA IDA: Inferred from direct assay	12560508	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	2833704	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12169688	GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	18293083	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	14701757	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	14979875	GOA
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	20371611	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	17827154	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	10393239	GOA
enables molecular adaptor activity	EXP EXP: Inferred from Experiment	22855260	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7824954	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	10393239	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12169688	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	18293083	GOA
enables transcription coregulator binding	IPI IPI: Inferred from physical interaction	14988427	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in positive regulation by host of viral transcription	IDA IDA: Inferred from direct assay	2833704	GOA
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	14580349	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12771217	GOA
acts upstream of positive regulation of amyloid-beta formation	IMP IMP: Inferred from mutant phenotype	14701757	GOA
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	23802567	GOA
involved in positive regulation of apoptotic signaling pathway	IDA IDA: Inferred from direct assay	18293083	GOA
involved in positive regulation of blood vessel endothelial cell migration	IMP IMP: Inferred from mutant phenotype	23802567	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23802567	GOA
involved in positive regulation of hydrogen sulfide biosynthetic process	IDA IDA: Inferred from direct assay	21659522	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	2833704	GOA
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	14979875	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	14701757	GOA
involved in positive regulation of vascular endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	23802567	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12560508	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in chromatin	IDA IDA: Inferred from direct assay	15831516	GOA
is active in euchromatin	IDA IDA: Inferred from direct assay	14701757	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	12498690	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12169688	GOA
part of transcription repressor complex	IDA IDA: Inferred from direct assay	16691198	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SP1 Protein Structure

zf-H2C2_2

0
200
400
600
785 a.a.

Protein Preferred Names	Protein Names
transcription factor Sp1	specificity protein 1

SP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	SP1	P08047	SF3A1	Homo sapiens	Q15459	Pull Down	10976766
Intra	SP1	P08047	POGZ	Homo sapiens	Q7Z3K3	Pull Down	10976766
Intra	SP1	P08047	KLF10	Homo sapiens	Q13118	Pull Down	10976766
Intra	SP1	P08047	DLX4	Homo sapiens	Q92988	Anti Bait CoIP	21297662
Intra	SP1	P08047	DLX4	Homo sapiens	Q92988	Anti Tag CoIP	21297662
Intra	SP1	P08047	ZBTB2	Homo sapiens	Q8N680	Pull Down	25609694
Intra	SP1	P08047	ZBTB2	Homo sapiens	Q8N680	CH-IP	25609694
Intra	SP1	P08047	STAT3	Homo sapiens	P40763	Anti Bait CoIP	21184768
Intra	SP1	P08047	POU2F1	Homo sapiens	P14859	Anti Bait CoIP	19070619
Intra	SP1	P08047	POU2F1	Homo sapiens	P14859	Pull Down	10976766
Intra	SP1	P08047	HCFC1	Homo sapiens	P51610	Anti Tag CoIP	12670868
Intra	SP1	P08047	HCFC1	Homo sapiens	P51610	Y2H	10976766
Intra	SP1	P08047	STAT3	Homo sapiens	P40763	PLA	24396070
Intra	SP1	P08047	POU2F1	Homo sapiens	P14859	Pull Down	19070619
Intra	SP1	P08047	HCFC1	Homo sapiens	P51610	Pull Down	10976766
Intra	SP1	P08047	STAT3	Homo sapiens	P40763	Anti Bait CoIP	24396070
Intra	SP1	P08047	SREBF2	Homo sapiens	Q12772	Y2H Pooling	20936779
Intra	SP1	P08047	SREBF2	Homo sapiens	Q12772	Pull Down	10976766
Intra	SP1	P08047	SMAD4	Homo sapiens	Q13485	Anti Bait CoIP	21297662
Intra	SP1	P08047	TP53	Homo sapiens	P04637	Anti Bait CoIP	15710382
Intra	SP1	P08047	AATF	Homo sapiens	Q9NY61	Anti Bait CoIP	12847090
Intra	SP1	P08047	HIF1A	Homo sapiens	Q16665	Competition Binding	17024177
Intra	SP1	P08047	E2F1	Homo sapiens	Q01094	Pull Down	8657141
Intra	SP1	P08047	CDKN2A	Homo sapiens	Q8N726	Pull Down	21555589
Intra	SP1	P08047	RUNX1T1	Homo sapiens	Q06455	Anti Tag CoIP	18519037
Intra	SP1	P08047	RUNX1T1	Homo sapiens	Q06455	Anti Bait CoIP	18519037
Intra	SP1	P08047	ELF1	Homo sapiens	P32519	Y2H	10976766
Intra	SP1	P08047	ESR1	Homo sapiens	P03372	Crosslink	9328340
Intra	SP1	P08047	ESR1	Homo sapiens	P03372	Pull Down	9328340
Cross	SP1	P08047	Nfya	Mus musculus	P23708	Beta Galactosidase	10393239

Cross: Cross-species interaction Intra: Intraspecies interaction

SP1 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P80336	SP1 Antibody (YA064)	WB, ICC/IF, IHC-P	Human
HY-P86620	SP1 Antibody (YA6312)	WB, IHC-P, ICC/IF, IP, ELISA	Human

Related Diseases

Diseases	Alias
Embryonal Carcinoma	Embryonal Neoplasm Embryonal Cancer Primary Extragonadal Embryonal Carcinoma Embryo Neoplasm Carcinoma Embryonal Cancer Embryonal Carcinoma, Embryonal Extragonadal Embryonal Carcinoma Cancer, Embryonal
Malignant Pleural Mesothelioma	Malignant Mesothelioma Of Pleura Pleural Malignant Mesothelioma
Erythroleukemia
Keratoconus	Kc Conical Cornea Noninflammatory Corneal Thining Bulging Cornea Cornea Conical Acquired Conus Of Cornea
Fibrosarcoma	Neoplasms, Fibrous Tissue Fibrocytic Tumor Fibrosarcoma Of Soft Tissue Fibrous Tissue Neoplasm
Machado-Joseph Disease	SCA3 MJD Spinocerebellar Ataxia 3 Azorean Disease Spinocerebellar Ataxia Type 3 Spinocerebellar Atrophy Azorean Neurologic Disease Spinopontine Atrophy Nigrospinodentatal Degeneration Spinocerebellar Atrophy Iii Spinocerebellar Atrophy Type 3 Azorean Ataxia Azorean Disease Of The Nervous System Machado Disease Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia Disease, Machado-Joseph Ataxia, Spinocerebellar
Von Hippel-Lindau Syndrome	Von Hippel-Lindau Disease Vhl Vhl Syndrome VHLS Von Hippel-Lindau Syndrome, Modifier Of Hippel Lindau Syndrome Angiomatosis Retinae Cerebelloretinal Angiomatosis, Familial Hippel-Lindau Disease Familial Cerebelloretinal Angiomatosis Lindau Disease VHLD
Teratocarcinoma	Mixed Embryonal Carcinoma And Teratoma
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Wilson Disease	Hepatolenticular Degeneration WD Wilson'S Disease WND Westphal-Strumpell Syndrome Copper Storage Disease Cerebral Pseudosclerosis Westphal Pseudosclerosis Hepatolenticular Degeneration Syndrome Copper Retention Hepatocerebral Degeneration Kinnier-Wilson Disease Neurohepatic Degeneration Progressive Hepatolenticular Degeneration Lenticular Degenerative Disease Wilson'S Syndrome Lenticular Syndrome
Huntington Disease	Huntington'S Disease Huntington Chorea Huntington'S Chorea HD Huntington Chronic Progressive Hereditary Chorea Juvenile Huntington Disease Chronic Progressive Chorea Chronic Progressive Hereditary Chorea Hc - [Huntington Chorea] Hereditary Chorea Progressive Hereditary Chorea
Cerebrotendinous Xanthomatosis	CTX Cerebral Cholesterinosis Cholestanol Storage Disease Xanthomatosis, Cerebrotendinous Sterol 27-Hydroxylase Deficiency Xanthomatosis Cerebrotendinous Cerebrotendinous Cholesterinosis Cholestanolosis Van Bogaert-Scherer-Epstein Disease
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Wolfram Syndrome	Didmoad Syndrome Didmoad Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Wfs Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, And Deafness Didmoadud Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Deafness Syndrome Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Hearing Loss Syndrome
Hereditary Hemorrhagic Telangiectasia	Rendu-Osler-Weber Disease Hht Osler-Weber-Rendu Disease Telangiectasia, Hereditary Hemorrhagic Osler Hemorrhagic Telangiectasia Syndrome Orw Disease Osler Weber Rendu Syndrome Osler-Rendu-Weber Disease Osler-Weber-Rendu Syndrome Rendu-Osler Disease Telangiectasia Hereditary Hemorrhagic Telangiectasia Hemorrhagic, Hereditary Hht - [Hereditary Haemorrhagic Telangiectasia] Osler Haemorrhagic Telangiectasia Syndrome
Xanthomatosis	Xanthomatosis, Susceptibility To Xanthelasmatosis
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Otosclerosis	Otospongiosis
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Vascular Disease	Vascular Diseases Aneurysm Spinal Cord Ischemia Vascular Anomaly Spinal Cord Vascular Diseases Vascular Tissue Disease
Colon Adenocarcinoma	Adenocarcinoma Of Colon Adenocarcinoma Of The Colon Colonic Adenocarcinoma
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Severe Combined Immunodeficiency	Scid Severe Combined Immunodeficiency Disease Combined T And B Cell Inborn Immunodeficiency Immunodeficiency, Severe Combined Scid - [Severe Combined Immunodeficiencies]
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Hard Palate Cancer	Malignant Neoplasm Of Hard Palate Malignant Tumor Of Hard Palate Malignant Tumour Of Hard Palate
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Cataract	Cataracts Cat - [Cataract] Cataract Form Lens Opacity Lens Opacities
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Amelogenesis Imperfecta, Type Ig	Enamel-Renal Syndrome Ers Amelogenesis Imperfecta Type 1g AI1G Enamel-Renal-Gingival Syndrome Amelogenesis Imperfecta And Gingival Fibromatosis Syndrome Aigfs Amelogenesis Imperfecta, Hypoplastic, With Nephrocalcinosis Amelogenesis Imperfecta Hypoplastic With Nephrocalcinosis Amelogenesis Imperfecta Type Ig Amelogenesis Imperfecta-Nephrocalcinosis Syndrome Amelogenesis Imperfecta 1g Hypoplastic Amelogenesis Imperfecta With Nephrocalcinosis Amelogenesis Imperfecta Nephrocalcinosis
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Polycystic Kidney Disease	Polycystic Kidney Diseases Pkd Polycystic Renal Disease Kidney Disease, Polycystic Polycystic Kidney, Autosomal Dominant
Ewing Sarcoma	Neuroepithelioma Ewing'S Tumor Primitive Neuroectodermal Tumor Ewings Sarcoma Ewing'S Sarcoma Peripheral Neuroepithelioma ES Ewings Sarcoma-Primitive Neuroectodermal Tumor Localized Peripheral Primitive Neuroectodermal Tumor Peripheral Primitive Neuroectodermal Tumor Ewing Tumor Sarcoma, Ewing'S Ewing Family Of Tumors Extraosseous Ewing Tumor Askin Tumor Ewing'S Family Localized Tumor Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing Sarcoma Localized Ewing'S Sarcoma Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing'S Tumor Pnet Of Thoracopulmonary Region Tumor Of The Ewing Family Skeletal Ewing Sarcoma Osseous Ewing Sarcoma Ppnet Peripheral Pnet Extraskeletal Ewing Sarcoma Eoe Extraosseous Ewing Sarcoma Extraskeletal Ewing Tumor Esft Ewing Sarcoma Family Of Tumors Pne Pnet Pnet Of The Chest Wall Sarcoma, Ewing Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumor, Primitive Disorder Of Eye Askin'S Tumor Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor Neuroepithelioma, Peripheral
Amelogenesis Imperfecta	Ai Congenital Enamel Hypoplasia Al - [Amelogenesis Imperfecta]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (2)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-A0122	Plicamycin	Inhibitor	99.60%	Unkown
HY-100008	Peretinoin		99.79%	Unkown

Clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-10447	Terameprocol		99.50%	Phase 2
HY-N0842	Bevirimat	Inhibitor	99.82%	Phase 2
HY-P10603	SP1	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (50)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-W040129	Chromomycin A3		99.66%	Unkown
HY-W100287	Murrayafoline A	Inhibitor	99.73%	Unkown
HY-N7078	Spiculisporic acid		99.88%	Unkown
HY-179528	DIM-3,5-Cl2		99.18%	Unkown
HY-P10336	Serpinin	Agonist	98.74%	Unkown
HY-RS13600	SP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W006646	Methyl 5-bromo-1H-pyrrole-2-carboxylate		98.43%	Unkown
HY-113542	Blasticidin A	Inhibitor	95%	Unkown
HY-125538	Deoxybrevianamide E		99.2%	Unkown
HY-RS16562	Sp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29499	SP1 Monkey Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W012589	tert-Pentylbenzene		98.85%	Unkown
HY-114585A	Sperabillin A dihydrochloride	Inhibitor	/	Unkown
HY-116077	AB 5046B		/	Unkown
HY-120764	PF-46396	Inhibitor	/	Unkown
HY-125458	Iromycin A	Inhibitor	/	Unkown
HY-129931	Phenylalanylphenylalanylamide		/	Unkown
HY-137462	Leucyl-phenylalanine amide		/	Unkown
HY-150536	EP39	Inhibitor	/	Unkown
HY-178021	HDAC1-IN-11		/	Unkown
HY-178022	HDAC6-IN-63		/	Unkown
HY-178143	Sp1-IN-1	Inhibitor	/	Unkown
HY-N12266	12-Hydroxyalbrassitriol		/	Unkown
HY-N16411	Carneamide A		/	Unkown
HY-N17478	(3β,5α,8α,22E,24ξ)-5,8-Epidioxyergosta-6,9(11),22-trien-3-ol		/	Unkown
HY-N19796	Diaporol I		/	Unkown
HY-N8662	Primulic acid II		/	Unkown
HY-P11688	Fmoc-PNA-M(Bhoc)-OH		/	Unkown
HY-P11689	Fmoc-PNA-J(Bhoc)-OH		/	Unkown
HY-P1330	Purotoxin 1	Inhibitor	/	Unkown
HY-P3805	[D-Pro4,D-Trp7,9,Nle11] Substance P (4-11)	Antagonist	/	Unkown
HY-RS03522	DAND5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11279	PSG1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-108993	Fujianmycin B		/	Unkown
HY-120551	Fructigenine A		/	Unkown
HY-123036	Renierone	Inhibitor	/	Unkown
HY-184043	Pinazaphilone A		/	Unkown
HY-N0980	1,4-Dihydro-1,2-dimethyl-4-oxo-3-quinolinecarboxylic acid		/	Unkown
HY-N12149	Axinysone B	Inhibitor	/	Unkown
HY-N13017	Bhimanone		/	Unkown
HY-N13149	Tetromycin C1	Inhibitor	/	Unkown
HY-N14206	Cytosporin B		/	Unkown
HY-N14403	6-Hydroxytetrangulol	Activator	/	Unkown
HY-N14576	Pyrrolomycin C	Inhibitor	/	Unkown
HY-N14577	Pyrrolomycin D	Inhibitor	/	Unkown
HY-N2657	Flavone, 5,7-dihydroxy-3,4',8-trimethoxy-, diacetate		/	Unkown
HY-N8339	Decatromicin B	Inhibitor	/	Unkown
HY-N8391	Hydroxysulochrin		/	Unkown
HY-N8849	4-Methyl-6,7-methylenedioxycoumarin	Inhibitor	/	Unkown
HY-RS22994	Sp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SP1	MGD	MGI:98372
Bos taurus	SP1	VGNC	VGNC:35152
Macaca mulatta	SP1	VGNC	VGNC:77844
Felis catus	SP1	VGNC	VGNC:65585
Canis familiaris	SP1	VGNC	VGNC:49654
Rattus norvegicus	SP1	RGD	RGD:3738
Others	SP1	NCBI