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Art. -Nr.: HY-190178

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Glue02

Glue02 is a CCNK molecular glue degrader with a DC₅₀ < 0.1 μM. Glue02 binds to the kinase domain of CDK12, promotes the formation of a ternary complex between CDK12 and the DDB1-CUL4-RBX1 E3 ubiquitin ligase complex, converts CDK12 into a substrate-specific receptor, and induces polyubiquitination and proteasomal degradation of CCNK. Glue02 inhibits cancer cell proliferation. Glue02 can be used in cancer-related research.

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CAS. Nr.: 2034581-68-3
Formel: C₁₅H₁₅N₇OS
Molecular Weight:341.39

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Glue02 Chemical Structure

CAS. Nr.: 2034581-68-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

CCNK

< 0.1 μM (DC₅₀)

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In Vitro

Anti-cancer

Glue02 concentration-dependently degrades CCNK (Cyclin K) protein in 293T cells, with DC₅₀ < 0.1 μM (Grade A)^[1].
Glue02 inhibits cancer cell proliferation through degradation of CCNK, IC₅₀ < 2 μM (Grade A)^[1].
Glue02 binds the CDK12 kinase domain and promotes the formation of a ternary complex between CDK12 and DDB1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS. Nr. 2034581-68-3
Molecular Weight 341.39
Formel C₁₅H₁₅N₇OS
SMILES

CC1=CN=C(NC(C2CN(C3=NC=NC(N4C=CC=N4)=C3)C2)=O)S1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Qi X, et al. A molecular glue regulating cdk12-ddb1 interaction to trigger cyclin k degradation. WO2021249517A1, 2021.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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Glue02

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