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Vincristine

(Synonyms: Leurocristine; NSC-67574; 22-Oxovincaleukoblastine)
75 Cited Publications
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Based on 75 publication(s) in Google Scholar

Vincristine (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) is a microtubule inhibitor that disrupts microtubule polymerization by binding to β-tubulin (with a Ki of 85 nM in bovine), arrests the cell cycle and induces apoptosis. Vincristine inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer, solid tumors and sarcomas.

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  • Reinheit: 98.13%
  • CAS. Nr.: 57-22-7
  • Formel: C46H56N4O10
  • Molecular Weight:824.96
  • Speicherung:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Vincristine Chemical Structure
  • Experimental Validation Results for Vincristine
  • Experimental Validation Results for Vincristine
  • Experimental Validation Results for Vincristine
  • Experimental Validation Results for Vincristine
  • Experimental Validation Results for Vincristine
  • Experimental Validation Results for Vincristine
  • Experimental Validation Results for Vincristine
  • Vincristine Chemical Structure
    Vincristine Chemical Structure
  • Experimental Validation Results for Vincristine
  • Experimental Validation Results for Vincristine
  • Experimental Validation Results for Vincristine
  • Experimental Validation Results for Vincristine
  • Experimental Validation Results for Vincristine
  • Experimental Validation Results for Vincristine
  • Experimental Validation Results for Vincristine
CAS. Nr.: 57-22-7
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IFCell Proliferation/Viability AssayApoptosis AnalysisWB
  • IF
  • Cell Proliferation/Viability Assay
  • Apoptosis Analysis
  • Cell Proliferation/Viability Assay
  • Cell Proliferation/Viability Assay
  • Apoptosis Analysis
  • WB
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  • Vincristine Chemical Structure
    Vincristine Chemical Structure
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    Vincristine purchased from MedChemExpress. Usage Cited in: Cell. 2025 Dec 11;188(25):7137-7154.e21. [Abstract]

    Customer Validation
     Representative IF images showing the colocalization between mSARM1 and the noted chemo-induced cytosolic dsDNA in neural cells. The noted neural cells were treated with 20 μM CP, 100 μM CBP, or 0.5 μM VCR (Vincristine) for 36 h, followed by IF analyses. Green: dsDNA stained with anti-dsDNA antibody; red: mSARM1 stained with anti-SARM1 antibody; blue: DAPI. Scale bar, 10 μm.

  • 1/16

    Vincristine purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2024 Apr;44(4):469-490. [Abstract]

    Customer Validation
     IC50 values of SGC7901VCR shNC and SGC7901VCR shA2B1 cells treated with VCR (Vincristine, 0.1-100 µg/mL; 48 h) and 5‐Fu (0.1-100 µg/mL; 48 h).

  • 1/16

    Vincristine purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2024 Apr;44(4):469-490. [Abstract]

    Customer Validation
     Apoptosis of SGC7901VCRshNC and SGC7901VCR shA2B1 cells treated with VCR (Vincristine, 1 or 15 µg/mL; 48 h) and 5‐Fu (1 or 20 µg/mL; 48 h).

  • 1/16

    Vincristine purchased from MedChemExpress. Usage Cited in: J Clin Invest. 2024 Mar 7;134(10):e172716. [Abstract]

    Customer Validation
     The given cell lines were treated with 250 nM osimertinib (Osim), 1.25 μM Etoposide (VP-16), 125 nM Doxorubicin (DXR), 5 nM Paclitaxel, 10 μM Cisplatin, 25 μM Carboplatin, 25 nM Gemcitabine, 20 nM 5-Fluorouracil (5-FU), 25 μM Cyclophosphamide, 25 μM Capecitabine, or 10 nM Vincristine alone or in combination for 3 days. Cell numbers were then measured using the SRB assay.

  • 1/16

    Vincristine purchased from MedChemExpress. Usage Cited in: Cell Mol Immunol. 2023 Jan;20(1):51-64. [Abstract]

    Customer Validation
     Comparison of drug (Epirubicin hydrochloride, EPI; Daunorubicin hydrochloride, DNR; Vinorelbine ditartrate, VNR; Oxaliplatin, OXA; Vincristine, VCR; Artemisinin, ART; Colchicine, COL) cytotoxicity to TC1 cells at the indicated doses and time points measured with CCK-8 assays. R.U. (Relative unit) was calculated from the average O.D. values in each condition as the indicator of cell viability (n = 3).

  • 1/16

    Vincristine purchased from MedChemExpress. Usage Cited in: Leukemia. 2021 Oct;35(10):2827-2839. [Abstract]

    Customer Validation
     TF-1 derivative cell lines were incubated with the indicated concentrations of vincristine (20 nM) or Regorafenib (10 μM) for 2 days, and the proportions of apoptotic cells were determined by staining with AnnexinV. Mean + SEM, n = 3.

  • 1/16

    Vincristine purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2019 May 1:128:574-582. [Abstract]

    Customer Validation
     SGC7901/DDP or SGC7901/VCR (Vincristine) cells are transfected with si-Con or si-ERK, and transfection efficiency is evaluated by western blot assay at 48 h post transfection.

  • Vincristine